August Research Round-Up

Congratulations to our amazing research teams here in the Department of Chemistry for their publications this month!

 

Blakey Group

 

Bowman Group

 

Brathwaite Group

 

Dyer Group

 

Evangelista Group

 

Kindt Group

 

Lian Group

 

Salaita Group

 

Wuest Group

 

 

Amy Solinski to Present at the ACS National Meeting

On the 25th of August, Amy Solinski will take the stage at the American Chemical Society National Meeting in San Diego to present at the Merck-sponsored Women Chemist Committee (WCC) Session. The opportunity is a wonderful recognition of Amy’s scientific excellence as well as her advocacy for women in science – she is a recipient of the 2018 ACS Georgia Section Women in Chemistry Scholarship, a member of the Georgia Chapter of the WCC, and a member of Emory’s Association for Women in Science (AWIS).

Amy Solinski’s contributions at Emory paint a picture of an engaged, curious, and creative scholar. From collaborations in the Wuest Lab and beyond to outreach with multiple organizations, she has had an impact on the Emory community. Her contributions to our community are made all the more impressive by the fact that, despite being a rising fifth year graduate student, she has only been at Emory for two years as of this June. She moved to Emory from Temple University with her advisor, Dr. Bill Wuest, when he joined the Emory faculty in 2017. Amy’s hobby of photography has had a visual impact on the community as well. Her work is featured on the Wuest Lab website, the Department of Chemistry website, and has been featured in multiple chemistry news stories.

In the Wuest Lab, Amy’s graduate research centers around the development of antibiotics derived from natural products. She uses chemical tools to study complex biological systems, specifically focusing on biofilm growth in the oral cavity. In fact, her manuscript, “Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans”, was recently published in ACS Infectious Diseases. This research will be the focus of her talk at the ACS meeting.

Amy appreciates the dynamic nature of the research in the Wuest lab. Although most of the research projects start with synthesis, they tend to branch out into medicinal chemistry, chemical biology, or other fields of chemical application. “You aren’t pigeonholed into one area of science,” says Amy. “If a project takes you in a new direction, you are encouraged to continue in that direction.” Fortunately, her lab members are keen to collaborate and, when she needed resources outside of her own lab, she was able to reach out to other labs. In fact, she has been a part of three separate collaborations so far!

When she isn’t spearheading collaborative research efforts, Amy is also a leader in the many organizations of which she is a member. For the AWIS Emory Graduate Student Chapter, Amy has served as the social networking chair, helping to plan networking events with other organizations. One event this last spring was a brunch social attended by members of the Georgia AWIS chapter, a few engineering organizations, and some members of the Georgia Tech community. As a member of the Georgia Chapter of the WCC, she has also helped manage communications efforts through social media.

Big things are on the horizon for Amy as she enters her fifth year. She has another manuscript soon to be published and has recently embarked on the search for a postdoc position. Although she is open to several possibilities, she is hoping to dive a little deeper into the realm of chemical biology. “I’m really into the idea of using synthesis and chemistry as a tool in biological systems,” Amy says. Her passion for research is matched by her passion for mentorship. Having mentored two undergraduate students and several younger graduate students, she is particularly interested in a career where she can provide one-on-one mentorship to students in a research setting.

“Research is hard!” says Amy. “Sometimes it’s hard to visualize the real impact, but persistence is key.” As she moves closer to the end of her graduate career, she is beginning to see the pieces of her project really come together. Amy is enthusiastic about her career trajectory, confident that she can reach her professional goals, and excited about her recent engagement! She is really looking forward to a bright and fulfilling future.

July Research Round-Up

Congratulations to our amazing research teams here in the Department of Chemistry for their publications this month!

 

Bowman Group

Havenith-Newen, M., Schwan, R., Qu, C., Mani, D., Pal, N., Schwaab, G., … & Bowman, J. Observation of the low frequency spectrum of water dimer as a sensitive test of the water dimer potential and dipole moment surfacesAngewandte Chemie.

Conticello Group

Hughes, S. A., Wang, F., Wang, S., Kreutzberger, M. A., Osinski, T., Orlova, A., … & Conticello, V. P. (2019). Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs. Proceedings of the National Academy of Sciences116(29), 14456-14464.

Merg, A., Touponse, G., van Genderen, E., Zuo, X., Bazrafshan, A., Blum, T., … & Conticello, V. P. (2019). 2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building BlocksAngewandte Chemie.

Davies Group

Fu, J., Wurzer, N., Lehner, V., Reiser, O., & Davies, H. M. (2019). Rh (II)-Catalyzed Monocyclopropanation of Pyrroles and Its Application to the Synthesis Pharmaceutically Relevant CompoundsOrganic Letters.

Heaven Group

VanGundy, R. A., Persinger, T. D., & Heaven, M. C. (2019). Improved vibrational constants for BaCl+ X1Σ+. Journal of Molecular Spectroscopy, 111176.

Sun, P., Zuo, D., Mikheyev, P. A., Han, J., & Heaven, M. C. (2019). Time-dependent simulations of a CW pumped, pulsed DC discharge Ar metastable laser system. Optics Express27(16), 22289-22301.

Hill Group

Kaledin, A. L., Muthukumar, K., Hill, C. L., & Musaev, D. G. (2019). Effects of Surface Hydration on the Electron Injection Rate from Graphene to Anatase and Rutile TiO2 SurfacesChemical Physics, 110463.

Lynn Group

Grover, M. A., Hsieh, M. C., & Lynn, D. G. (2019). Systems Analysis for Peptide Systems ChemistryLife9(3), 55.

Musaev Group

Kaledin, A. L., Muthukumar, K., Hill, C. L., & Musaev, D. G. (2019). Effects of Surface Hydration on the Electron Injection Rate from Graphene to Anatase and Rutile TiO2 SurfacesChemical Physics, 110463.

Salaita Group

Salaita, K., Wongtrakool, C., & Galior, K. (2019). S. Patent Application No. 16/304,549.

Merg, A., Touponse, G., van Genderen, E., Zuo, X., Bazrafshan, A., Blum, T., … & Conticello, V. P. (2019). 2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building BlocksAngewandte Chemie.

Salaita, K. S., Schumacher, C., & Stabley, D. R. (2014). S. Patent Application No. 14/347,095.

Wuest Group

Solinski, A. E., Scharnow, A. M., Fraboni, A. J., & Wuest, W. M. (2019). Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutansACS Infectious Diseases.

Korobeynikov, V., Borakove, M., Feng, Y., Wuest, W. M., Koval, A. B., Nikonova, A. S., … & Shagisultanova, E. (2019). Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancerBreast cancer research and treatment, 1-14.

Cheng, A. V., Kim, W., Escobar, I. E., Mylonakis, E., & Wuest, W. M. (2019). Structure–Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic RetinoidsACS Medicinal Chemistry Letters.

Morrison, K. R., Allen, R. A., Minbiole, K. P., & Wuest, W. M. (2019). More QACs, more questions: recent advances in structure activity relationships and hurdles in understanding resistance mechanismsTetrahedron Letters.

Bill Wuest Named Leshner Fellow

 

Bill Wuest speaks to a reporter during the 2019-2020 AAAS Leshner Leadership Fellows orientation week.

Human augmentation. Sounds like the theme of a highly-rated, futuristic SciFi movie, right? In the realm of chemistry, however, the idea of enhancing human capability often guides some of the most impactful research. For example, research in the Wuest lab is focused on the development of new antibiotics inspired by nature. From identifying and synthesizing to characterizing and optimizing, researchers in the Wuest lab hope to improve upon natural products with the ultimate goal of commercialization. Because of their ability to alter the human microbiome, the therapeutic use of these antibiotics lends itself to improving the human function.

These research efforts recently earned Dr. Wuest the distinction of being named a Leshner Leadership Institute Public Engagement Fellow. The Leshner Fellow program was developed by the American Association for the Advancement of Science (AAAS) to train scientists to be more active in public engagement and government policy discussions. Each year, the program selects a theme that they deem to be of importance in the realm of public engagement. The theme of the year was Human Augmentation, which followed such past themes as Infectious Diseases, Food and Water Security, and Climate Change.

Leshner Fellows visit with staff in Rep. Bill Foster’s office.

As a Leshner Fellow, Dr. Wuest was given the opportunity to participate in a week-long orientation designed to facilitate issue-specific scientific communication and to encourage attendees to serve as leaders in public engagement. Instructional modules covered topics from video production and graphics to social media. “We met with a panel of journalists to learn how to engage with them about research stories we are working on,” says Dr. Wuest. “We received training in how to engage policy makers on Capitol Hill and create one page ‘drop sheets’. We also were instructed on how to give televised interviews and participated in one recording for the Leshner video.” In addition, the meeting provided a stage for attendees to initiate collaborations with other leaders in the field.

Fellows on Capitol Hill.

“The highlight of the week was our visit to Capitol Hill,” says Dr. Wuest. He met with staff members of the Senate Commerce Committee, The House Committee on Science and Technology, and with the office of Representative Bill Foster (D-IL), with whom he was able to communicate his passion for graduate student training and the need for diversity and inclusion in the sciences (the current focus of two bills in Congress). “I focused my pitch on the specific training of graduate students through an increase in federal funding to fellowships and training grants as opposed to directly to the PI, which is the primary mode of funding graduate students currently,” he explains. This concept is also the topic of an op-ed that he is co-writing with 4 other fellows.

At the end of the orientation week, Dr. Wuest walked away with answers to such questions as “How do you engage writers and editors?”, “What is the best approach to impacting policy?”, and “What is the best way to make institutional change within your organization?”. Moreover, each fellow was guided towards developing and implementing two engagement plans for the upcoming year. For Dr. Wuest, the first plan is centered around educating the public on the issues of antimicrobial resistance and the development of new antibiotics. “My plan involves writing a number of op-eds to educate the public as well as organizing public forums around the topic,” he says. For his second plan, Dr. Wuest is focusing on the further development of a culture of innovation and entrepreneurship at Emory University. This aim, he says, is derived from his relationship with the Georgia Research Alliance. In collaboration with Emory, this organization awarded him a Distinguished Investigator endowed chair when he moved here in 2017.

“The experience has made a significant impact on how I think about communicating my science and the reach I would like my findings to have,” says Dr. Wuest. He is already capitalizing on some of the training he received during orientation, having recently engaged with a number of journalists to help share his message. He had an interview with NPR regarding a recent publication that is set to air sometime this month, and he contacted Senator Isakson (R-GA) who currently has proposed a bipartisan bill, the DISARM Bill, which seeks to address the issue of antibiotic development in the private sector.

Beyond just sharing his interest in antibiotics and research, Dr. Wuest also hopes to inspire others to take a similar approach to communicating their own science. “I would encourage not only faculty but students as well to think more broadly about public engagement in all areas, whether it be social media, SciComm, writing op-eds, emailing local representatives, etc.,” he says. “Without public support, a lot of the science we do will not be possible.”

If you are a student interested in similar programs to the one described here, check out the AAAS Fellowships website!

To read more about the research in the Wuest lab, check out this article in Emory News.

2019-2020 AAAS Leshner Leadership Fellows

All photo credit to Mary Catherine Longshore, AAAS

Mallory Theis is a Reaxys PhD Prize Finalist

Congratulations to Mallory Theis (Heaven Lab) for being selected as a finalist for the Reaxys PhD Prize 2019 for her publication “Dative Bonding between Closed-Shell Atoms: The BeF– Anion“.  The prize, given by Elsevier, recognizes accomplished young chemists for innovative and rigorous research. It is considered the world’s most prestigious award for PhD students in the chemical sciences.

As a finalist, Mallory is invited to this year’s Reaxys PhD Prize Symposium, which will take place in Amsterdam on October 3 and 4. At the symposium, attendees get the opportunity to meet with other finalists as well as members of the Reaxys Advisory Board. In addition, students will have the chance to showcase their research during a poster presentation session.

Gábor Czakó Receives Momentum Research Grant

Congratulations to Dr. Gábor Czakó, who recently received the Momentum Grant of the Hungarian Academy of Sciences. Dr. Czakó was a postdoctoral fellow in the Bowman group and is currently an Associate Professor and the head of the Computational Reaction Dynamics Research Group at the University of Szeged (Szeged, Hungary).

The Momentum Program of the Hungarian Academy of Sciences was designed to motivate young Hungarian researchers to continue their research efforts in Hungary. The program provides the most prestigious and competitive grant in the country, awarded to only one or two chemist(s) annually.

 

June Research Round-Up

Congratulations to our amazing research teams here in the Department of Chemistry for their publications this month!

Bowman Group

Stancil, Phillip C., et al. “Rovibrational excitational of diatomic molecules due to H2 collisions: Waiting for Webb.” American Astronomical Society Meeting Abstracts. Vol. 234. 2019.

Davies Group

Garlets, Zachary J., et al. “Regio-and Stereoselective Rhodium (II)-Catalyzed C–H Functionalization of Organosilanes by Donor/Acceptor Carbenes Derived from Aryldiazoacetates.” Organic letters(2019).

Heemstra Group

Heemstra, Jennifer. “Self‐care is not the enemy of performance.” ChemBioChem(2019).

Hill Group

Stancil, Phillip C., et al. “Rovibrational excitational of diatomic molecules due to H2 collisions: Waiting for Webb.” American Astronomical Society Meeting Abstracts. Vol. 234. 2019.

Lian Group

Huang, Zhiyuan, et al. “Enhanced near-infrared-to-visible upconversion by synthetic control of PbS nanocrystal triplet photosensitizers.” Journal of the American Chemical Society(2019).

Salaita Group

Salaita, Khalid, Jessica Petree, and Kevin Yehl. “Particles Coated With Catalysts Useful for Splicing Nucleic Acids.” U.S. Patent Application No. 16/180,786.

Wuest Group

Wuest, William M. “Novel Promysalin Analogues and Methods of Use Thereof.” U.S. Patent Application No. 16/091,685.

 

 

May Research Round-Up

Congratulations to our amazing research teams here in the Department of Chemistry for their publications this month!

Blakey Group

Burman, J., Harris, R., Farr, C., Bacsa, J., & Blakey, S. B. (2019). Rh (III) and Ir (III) Cp* Complexes Provide Complementary Regioselectivity Profiles in Intermolecular Allylic CH Amidation ReactionsACS Catalysis.

Davies Group

Davies, H. M., & Liao, K. (2019). Dirhodium tetracarboxylates as catalysts for selective intermolecular C–H functionalizationNature Reviews Chemistry, 1.

Heaven Group

Schmitz, J. R., Kaledin, L. A., & Heaven, M. C. (2019). Laser induced fluorescence spectroscopy of jet-cooled ThOJournal of Molecular Spectroscopy.

Hill Group

Wang, X., Tao, M., Li, Y., Zhang, X., Li, Z., & Hill, C. L. (2019). A Polyoxometalate‐Based Microfluidic Device for Liquid Phase Oxidation of GlycerolChemSusChem.

Ke Group

Zhang, Y., Pan, V., Li, X., Yang, X., Li, H., Wang, P., & Ke, Y. (2019). Dynamic DNA StructuresSmall, 1900228.

Zhang, Y., Peng, R., Xu, F., & Ke, Y. (2019). Hierarchical Self-Assembly of Cholesterol-DNA NanorodsBioconjugate chemistry.

Lian Group

Ge, A., Rudshteyn, B., Videla, P. E., Miller, C. J., Kubiak, C. P., Batista, V. S., & Lian, T. (2019). Heterogenized Molecular Catalysts: Vibrational Sum-Frequency Spectroscopic, Electrochemical, and Theoretical InvestigationsAccounts of chemical research.

Salaita Group

Ma, V. P. Y., & Salaita, K. (2019). DNA Nanotechnology as an Emerging Tool to Study Mechanotransduction in Living SystemsSmall, 1900961.

Two Chemistry Majors Awarded Prestigious Goldwater Scholarship

Chemistry majors Austin Lai and Liz Enyenihi have been selected as 2019 Goldwater Scholars, the nations’ premier scholarship for undergraduates studying math, natural sciences, and engineering. The college juniors will each receive $7,500 per year until the completion of their undergraduate degree to go towards the cost of tuition, fees, books, and room and board. This year, the competition received over 5,000 applications for only 496 scholarships.

A Woodruff Scholar, Enyenihi has modeled RNA exosome malfunction in a budding yeast model system to explore why the mutations in the genes that encode components of this complex cause such distinct, sometimes fatal, diseases working in the lab of Dr. Anita Corbett.

Lai, a biology and chemistry double major, is researching Fragile X Syndrome in the lab of Dr. Gary J. Bassell, professor and chair of the Department of Cell Biology in the School of Medicine.

Read more about these amazing scholars, and all four 2019 awardees from Emory, in the Emory Report. [Full Article]