On Wednesday, September 19th, Dr. Guangbin Dong joined us from the University of Chicago for the 2018 Padwa Lecture. This lecture, “Site-Selective C—C and C—H Functionalization of Ketones”, was made possible by the generous support from Emeritus Professor Al Padwa. The lecture highlighted important discoveries in the field of C—C and C—H Functionalization, including a regioselective ketone α-alkylation reaction using simple olefins and an approach for catalytic C-C bond activation of cyclopentanones and some cyclohexanones.
At the end of April, the CCHF hosted a Communicating Science Workshop given by playwright, chemist, and educator Holly Walter Kerby. During the workshop, Kerby provided training in the tools and concepts behind story-telling to an audience of enthusiastic students and faculty members. As Founder and Executive Director of Fusion Science Theater (FST), Kerby uses her own scientific story-telling in Science, Technology, Engineering, Arts, and Math (STEAM) outreach. The idea behind FST is to engage children in learning science by capitalizing on the techniques of theater. Through entertaining and educational demonstrations, FST promotes curiosity in the next generation of scientists.
In the first of two workshops, Kerby’s workshop taught the techniques of FST to graduate students and postdocs with a focus on the techniques of story-telling from scientific question to conclusion. Attendees were encouraged to use their research as a “plot” to develop their own stories. Participants used small graphic visual aids to help move the story along. Kerby helped Emory scientists to see how the ability to design and deliver a story is unquestionably valuable in the scientific community. From giving a presentation at a conference to participating in outreach events, scientists are required to engage and inform a wide audience. Story-telling has been proven to be a more impactful way of sharing information, making it particularly useful in the scientific arena.
In her second workshop, Kerby helped attendees capitalize on their storytelling skills to develop demonstrations to be used at future outreach events. Students put together presentations covering topics from catalysis to C-H functionalization, primarily targeted towards young audiences. The presentations were also designed to encourage audience participation using a show of hands or a vote. Kerby explained that engaging the audience in this way peaks their enthusiasm for the material and provides meaningful feedback regarding the effectiveness of the presentation. The afternoon was spent developing ideas, building props, and rehearsing.
When the second day of the workshop rolled around, presenters were prepared to show off their demonstrations in front of an audience. The room was filled with guests—including chemistry faculty and staff— who served as the audience for the demos and then provided valuable feedback on how to further refine them for future use. Keep an eye out for some of the unique demonstrations at next year’s Atlanta Science Festival!
Thank you to the CCHF and Holly Walker Kerby for fantastic workshop!
Interested in participating in more CCHF events? Click here!
Interested in learning more about FST? Click here!
On Wednesday, January 10th, the Center for Selective C-H Functionalization (CCHF) hosted ‘Chemistry in the Pharmaceutical Industry’, a symposium organized to celebrate chemistry in the pharmaceutical sciences. The event featured speakers across academia and industry to provide a comprehensive view of some recent advances in the pharmaceutical field.
“Leveraging Industrial/Academic Collaborations to Increase Access of New 3-Dimensional Architectures”
“Scaling Photoredox Catalysis in Flow”
“Designing PDGFR inhibitors for duration of action after inhaled delivery”
“Radical Conjugate addition of alkyl bromides to α,β-unsaturated amides and esters via photoredox catalysis”
“Catalytic Site- and Enantioselective Electrophillic Aromatic Substitutions”
The lectures were followed by a poster session during which new advances in the field were presented and discussed.
Happy New Year! As we welcome 2018, let’s reflect on some of the great things that happened during 2017.
- Francesco Evangelista was awarded the 2017 Dirac Medal, one of the world’s most prestigious awards for theoretical and computational chemists under 40
- The Department launched “The Chemmys” seminar series with Dr. W. Carl Lineberger giving the inaugural keynote speech
- ChEmory held their inaugural alumni career panel featuring three distinguished alums, Dr. Vicky Stevens, Dr. Holly Carpenter, and Nelly Miles
- Bill Wuest joined the Emory Department of Chemistry faculty
- Morgan McCabe joined the Department of Chemistry as Lead Research Specialist
- ChEmory students traveled to San Francisco to attend the ACS Meeting
- Joel Bowman was selected as one of three keynote speakers at the International Conference on Computational Science and its Applications in Trieste, Italy
- Dennis Liotta gave the keynote address at the Molecular and Systems Pharmacology Graduate Program Symposium
- Huw Davies received the Humboldt Research Award for lifetime achievement in the sciences
- The Hill Group received over 1000 citations on their paper “Polyoxometalates in Medicine”
- Ian Pavelich was awarded an Advancing Science in America Fellowship, an award for academically outstanding students in science, engineering, and medical research
- The Wuest Group was featured of the August Issue of ChemBioChem
- Craig Hill was elected as a Fellow of the Royal Society of Chemistry for his impactful contributions to the field of chemical sciences
- The Department of Chemistry kicked off its Diversity, Equity, and Inclusion Initiative with its “Strategies and Tactics for Recruiting to Improve Diversity and Excellence (STRIDE) seminar
- ChEmory was recognized by the American Chemical Society as a commendable chapter for 2016-2017, placing ChEmory in the top 10-20% of all undergraduate ACS chapters
- The Department of Chemistry joined the Twitterverse @EmoryChem
- Morgan Vaughn of the Dyer Group was awarded a Dean’s Teaching Fellowship, an award designed to allow advanced students to design and teach a course
- Vincent Conticello was quoted in Chemistry World discussing protein materials
- The Center for Selective C-H Functionalization received a $20 Million Renewal from the NSF
- Bill Wuest received the 2017 ACS Infections Diseases Young Investigator Award for his research on bacterial biofilms and antibiotic resistance
- Chemistry Unbound revolutionized the undergraduate chemistry program
- Elaine Liu received the Advancing Science in America (ARCS) Award, an award for academically outstanding students to help fund the “seed stage” of their work and discovery
- The Lynn Group was featured in Organic and Biomolecular Chemistry
- Victor Ma received the Predoctoral to Postdoctoral Fellow Transition Award from the NIH to fund his remaining thesis work and future postdoctoral work
- Members from the Department of Chemistry and the CCHF attended the SACNAS symposium and outreach event at the Leonardo Museum
- The Salaita Group research on “Picky Platelets” was featured in Medical Express
Chemists have developed another catalyst that can selectively activate a carbon-hydrogen bond, part of an ongoing strategy to revolutionize the field of organic synthesis and open up new chemical space.
The journal Nature is publishing the work by chemists at Emory University, following on their development of a similar catalyst last year. Both of the catalysts are able to selectively functionalize the unreactive carbon-hydrogen (C-H) bonds of an alkane without using a directing group, while also maintaining virtually full control of site selectivity and the three-dimensional shape of the molecules produced.
Read the full story by Carol Clark on the Emory esciencecommons blog!
Along with facilitating conversations about synthetic organic chemistry between professionals across a global platform, the NSF Center for Selective C-H Functionalization (CCHF), based at Emory University’s Department of Chemistry, also strives to increase scientific awareness to broader audience. They explain on their website, “A large part of the Centers mission is to bring C–H Functionalization into the mainstream of organic chemistry and one of the key ways we are seeking to do that is informing future generations of scientists by engaging students from K through 12.” By partnering with various organizations in outreach initiatives, the CCHF can connect with the community and share some of their fascinating scientific happenings.
Recently, some members of the Emory Department of Chemistry travelled to Utah to attend the Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) conference. During the event, our representatives, in collaboration with the CCHF, participated in recruiting, dissemination of infomercials, research seminars, and poster judging. Dr. Cora MacBeth gave a presentation in a technical symposium organized by alumni, Omar Villanueva. Emory University even had a booth at the event where Dr. Lloyd Munjanja of the CCHF, Monica Kiewit of the Dyer Group, and Bryant Chica of the Dyer Group could interact with visitors.
During the conference, the Center partnered with the Leonardo Museum of Creativity and Innovation in an outreach event organized through the collaborative effort of the Directors of Education, Outreach, and Diversity from 3 NSF Centers for Chemical Innovation, Dr. Lloyd Munjanja (CCHF), Dr. Danielle Watt (CaSTL), and Christopher Parsons (CCE). CCHF members from the Sigman and Du Bois research labs interacted with over 100 middle school students and their teachers through a series of hands-on chemistry activities and demonstrations. One activity involved the students building molecules from marshmallows and toothpicks!
Some photos from the SACNAS conference and the outreach event at the Leonardo Museum of Creativity and Innovation are shown below.
Emory’s Center for Selective C-H Functionalization has received a five year, $20 million renewal from the National Science Foundation. The CCHF is part of NSF’s Centers for Chemical Innovation (CCI) program that supports research centers focused on major, long-term fundamental chemical research challenges. The CCHF aims to bring about a paradigm shift in the logic of chemical synthesis, one that has the potential to impact the construction of all organic molecules. The Center is headquartered at Emory, but has satellite centers at research universities across the U.S. and internationally including UC Berkeley, Stanford, Princeton, and Georgia Tech, among others. The CCHF also works with industrial collaborators, including Novartis, Merck, and AbbVie.
Center Director Huw Davies says, “We are very excited with this opportunity because we feel the momentum of the CCHF continues to build. An Outlook of the CCHF has just been published, which summarizes what we have achieved so far and where we plan to go in the future.”
As with all CCI, the CCHF also has an outreach mission, seeking to share their science with the public. They are regular participants in the Atlanta Science Festival and sponsors of the Graduate School Prep Club. The CCHF has also pioneered the use of virtual symposia offering talks by researchers that take place at one institution and are simulcast to partner centers and the public worldwide, reaching thousands of viewers.
Congratulations to Dr. Davies and all Center staff, students, and faculty on this major grant renewal!
In November and December, Emory is hosting a special series of Merck lectures on process chemistry. Merck is one of the largest pharmaceutical companies in the world. Emory is only the third graduate school to host lectures in this series—previously, the Merck lectures were held at Berkeley and Princeton. The lectures are part of a special graduate course being taught by Dennis C. Liotta and Huw Davies, CHEM 729R: Special Topics in Chemistry: Process Chemistry in Research.
The lectures are part of the “Preparing Future Innovators” series developed by the NSF-funded Center for Selective C-H Functionalization. Preparing Future Innovators offers lectures that prepare chemistry graduate students for a broad range of future careers via interactions with leaders in chemical industry.
The Merck lectures feature Merck leadership working in the field of process chemistry. The lectures seek to highlight the important differences between process chemistry and medicinal chemistry, particularly the ways in which process chemists can develop techniques that help to bring medical innovations to the public. Students attending the lectures will be better prepared to understand the differences between medicinal chemistry and process chemistry and will therefore by better able to consider a range of careers that apply chemistry to human health.
In addition to the lectures, visitors are attending meet-and-greet and lunches with students. Huw Davies, the Director of the Center for Selective C-H Functionalization, says “This is a great opportunity for our students and faculty to become familiar with cutting edge research in the pharmaceutical industry, and for the Emory chemistry department to develop a close relationship with Merck.”
Merck Lectures in Process Chemistry Schedule
All lectures take place from 4-6pm in Atwood 360. Current Students, there will be a Meet-and-Greet with Merck visitors at 11am on the day of each lecture in Atwood 316.
November 1st, 2016:
Merck Process Chemistry: Discovery & Development Of Innovative Synthetic Methods To Drive Best Chemistry
Rebecca T. Ruck, Ph.D.
Director, Process Chemistry, Merck Process Research & Development
Merck Milestones in Chemistry: Medicine through Inspired Science
Michael H. Kress, Ph.D.
Vice President, Process Research and Development, Rahway NJ
November 29th, 2016:
Enabling High-Throughput Experimentation through High-Throughput Analysis
Yun Mao, Ph.D.
Director, Analytical Research and Development, Merck Research Laboratories
High-throughput Experimentation For Chemists: Rationally Designed Large Arrays Of Experiments For Solving Complex Chemical Problems
Associate Principal Scientist, Catalysis Laboratory,Department of Process Research & Development
December 6th, 2016:
Biocatalysis At Merck
Matt Truppo, Ph.D.
Executive Director, Merck & Co., Inc
Best Chemistry And World Class Supply
Ian Davies, Ph.D.
Department of Process Research & Development, Merck & Co., Inc.
Graduate students aren’t often tasked with completing that classic elementary school assignment: “How I Spent My Summer Vacation.” But Robert Kubiak has a great answer. After being accepted into Emory’s graduate program in chemistry, he got a jump start on his research by completing a summer rotation in the Davies Lab. This experience contributed to his successful application for the prestigious NSF Graduate Research Fellowship Program. Robert says: “One critical aspect that the reviewers said was helpful in my application was that I had already began to reach out to the community here in Atlanta and take on leadership roles at Emory. Doing a summer rotation before the fall semester was key to making these connections.”
The National Science Foundation received over 17,000 applications this year for the Graduate Research Fellowship program and made 2,000 award offers. As one of the 2016 awardees, Robert will receive three years of tuition and a stipend from NSF. The award is intended to recognize promising scientists at the beginning of their careers, giving them the resources to reach their career goals.
Before starting at Emory, Robert served as a platoon senior medic in the Army’s 3rd Ranger Battalion. He brings this unique leadership experience to his work in chemistry through a commitment to building community using science. “I am really interested in working to introduce scientific conversations to those who may not realize the profound impact science has on every aspect of our daily lives. I hope to encourage young students to embrace scientific discovery and pursue careers in the STEM fields,” he says.
Robert’s research at Emory takes place in the context of the NSF Center for Selective C-H Functionalization. “C–H functionalization is new, relevant, and rapidly changing the way we approach organic synthesis. C–H functionalization bypasses the need for traditional functional groups saving time, money, and reducing the waste associated with synthesis.” Robert’s research project focuses on developing novel catalysts for N-sulfonyltriazoles–nitrogen-based compounds. This research has the potential for broad impact as nitrogen is found everywhere in nature and is an important component of many pharmaceuticals. “Inserting nitrogen through functionalization will save time and money in pharmaceutical synthesis,” explains Robert.
The research also has the potential to lead Robert on new professional adventures. “The CCHF offers a study abroad component, and this research would facilitate a great opportunity to collaborate with the Iatmi group in Japan.” The NSF award also opens up the possibility to participate in NSF’s Graduate Opportunities Worldwide (GROW) program. “I would like to take advantage of GROW to study abroad,” says Kubiak. “It will be an opportunity to develop my ability to teach basic scientific skills—ideally in a community where access to higher scientific education is limited.”
Robert’s proposal was completed in chemistry’s Proposal Writing Course, led by Frank McDonald. Robert says that his experience in the course was “absolutely critical in articulating my past experiences in a meaningful way that made me a competitive applicant.” Robert hopes to draw on the resources of the award to further develop his own mentoring skills. “I plan on working very hard over the next couple of years to develop a robust understanding of organic chemistry, my skills as a research scientist, and my proficiency as a mentor in the field. Fortunately, these goals go hand-in-hand together.”
Emory was well represented at the National Organization for Black Chemists and Chemical Engineers Conference (NOBCChE) last week.
Wallace Derricotte (Graduate Student, Evangelista Group) gave a research talk and received the ACS “Graduate Student Exchange Award” at NOBCChE. The award is a joint program between the American Chemical Society and other chemistry related organizations to provide students of these satellite organizations with travel funds for ACS national and regional conferences.
Keon Reid (Graduate Student, Kindt Group) received a NOBCChE conference award, the “Advancing Science Travel Grant.” The award covers registration and hotel costs for the conference and is intended to encourage graduate students and postdocs to attend NOBCChE in recognition of the integral contributions they make to the conference community. Keon also gave an excellent poster presentation at the conference.
Congratulations, Wallace and Keon!
Monya Ruffin, Senior Scientist and Director of Community, Diversity, and Outreach in the CCHF Center at Emory, gave a professional development talk on science communication.