Congratulations, Dr. Eric Andreansky!

Eric Andreansky successfully defended his dissertation, “Synthetic Studies Toward Methanoquinolizidine-Containing Akuammiline Alkaloids ” on Wednesday, April 26th, 2017. Eric’s committee was led by Simon Blakey with Frank McDonald and Lanny Liebeskind as additional members.

Eric was a Laney Graduate School Woodruff Scholar. He was also a service instructor for the Emory NMR Research Center and interned for a year with the Emory Office of Technology Transfer. Eric was also a member of the first Broadening Experiences in Scientific Training (BEST) cohort, a National Institute of Health-funded graduate training program run jointly with Emory and the Georgia Institute of Technology.

Eric plans to pursue a career in patent law.

Congratulations, Eric!

Khalid Salaita and Dennis Liotta Recognized with 2015 OTT Awards

Khalid Salaita with award
Photo via Emory Report. See the full article below for more photos from the OTT awards ceremony.

Khalid Salaita was awarded the Innovation of 2015 award by Emory’s Office of Technology Transfer for the project “Motion-based Detection by DNA Machines.” Dennis Liotta received the Deal of 2015 award along with collaborators from the Emory Institute for Drug Development.

Deal of 2015: Bristol-Myers Squibb – CXCR4 Antagonists

Dennis Liotta (chemistry) and Lawrence Wilson and Michael Natchus (Emory Institute for Drug Discovery)

CXCR4 protein expression is low or absent in many healthy tissues, but it was shown to be expressed in more than 20 types of cancer, including prostate, ovarian and breast cancer, and melanoma. Emory researchers have developed small molecules that act as antagonists to CXCR4 and may be orally administered.

CXCR4 antagonists are known to block adhesion, replication and outgrowth of HIV and can mobilize white blood cells. In 2015, Emory executed a high net worth license for the technology and research collaboration with Bristol-Myers Squibb.

Innovation of 2015: Motion-based Detection by DNA Machines

Khalid Salaita (chemistry)

Single Nucleotide Polymorphism (SNP) genotyping is the screening and analysis of genetic variations of SNPs, which are common in all species including humans. SNP genotyping and analysis technology can analyze thousands of SNPs and has the potential for whole-genome genotyping. DNA-based machines have potential in several applications and industries, but DNA machines called “walkers” are challenging to work with due to their low fidelity and slow rates.

Emory inventors have developed a DNA-based machine that converts chemical energy into controlled motion. Because these DNA-based machines “roll” rather than “walk,” they are able to surpass the maximum speed of existing DNA motors by three orders of magnitude. This technology can serve as a new and powerful tool in SNP genotyping, as well as other applications in diagnostics, drug delivery and biomaterials.

[Full Article]