Authors: Huw M. L. Davies Prof., Chandrasekar Venkataramani
Angew. Chem. Int. Ed.,
2002, 41, 12, 2197-2199
A very direct approach for the synthesis of β-amino esters is provided by catalytic asymmetric C–]H activation by means of carbenoid-induced C–H insertion (see scheme; Boc=butyloxycarbonyl; TFA=trifluoroacetic acid). The reactions described herein represent the first regioselective intermolecular C–H insertions occurring at a methyl site.