120. Catalytic Enantioselective Synthesis of β2-Amino Acids

Authors: Huw M. L. Davies Prof., Chandrasekar Venkataramani

Angew. Chem. Int. Ed., 

20024112, 2197-2199


A very direct approach for the synthesis of β-amino esters is provided by catalytic asymmetric C–]H activation by means of carbenoid-induced C–H insertion (see scheme; Boc=butyloxycarbonyl; TFA=trifluoroacetic acid). The reactions described herein represent the first regioselective intermolecular C–H insertions occurring at a methyl site.

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