123. Asymmetric synthesis of (+)-indatraline using rhodium-catalyzed C–H activation

Authors: Huw M.L. Davies, Timothy M. Gregg

Tetrahedron Lett., 

20024328, 4951-4953


The potent monoamine reuptake inhibitor (+)-indatraline, 1, was prepared in greater than 98% ee employing a highly enantioselective carbenoid C–H insertion reaction into 1,4-cyclohexadiene catalyzed by the chiral rhodium complex, Rh2(S-DOSP)4.

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