143. Double C−H Activation Strategy for the Asymmetric Synthesis of C2-Symmetric Anilines

Authors: Huw M. L. Davies and Qihui Jin

Org. Lett.,

2004, 6 (11), 1769–1772


Rh2(S-DOSP)4-catalyzed C−H activation to N,N-dimethylanilines is described. A double C−H activation was possible by using an excess of methyl aryldiazoacetate, and this provided a very direct approach to C2-symmetric anilines.

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