159. Sequential Cycloaddition Approach to the Tricyclic Core of Vibsanin E. Total Synthesis of (±)-5-epi-10-epi-Vibsanin E

Authors: Huw M. L. Davies , Øystein Loe , and Douglas G. Stafford

Org. Lett.,

2005, 7 (25), 5561–5563

ol052005cn00001

A direct access to (±)-5-epi-10-epi-vibsanin E is described, based on three key cycloaddition steps, a rhodium-catalyzed [4 + 3] cycloaddition, a heteronuclear [4 + 2] cycloaddition, and a photochemically induced [4 + 2] cycloaddition.

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