166. Enantioselective synthesis of β-amino esters and its application to the synthesis of the enantiomers of the antidepressant Venlafaxine

Authors:Huw M. L. Davies and Aiwu Nia

Chem. Commun.,

2006, 3110-3112


β-Amino esters are readily formed from the rhodium(II) prolinate-catalyzed intermolecular C–H insertion between methyl aryldiazoacetates and a bis-silyl protected methylamine.

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