201. Total Synthesis of (±)-Vibsanin E

Authors: Brett D. Schwartz, Justin R. Denton, Huw M. L. Davies, Craig M. Williams

Australian J. Chem.,

200962, 980-982

Vibsanin E (1), a structurally rare complex diterpene, consisting of a compact 3-oxatricyclo[,10] tridecane core and an unprecedented 3,3-dimethylacroyl enol ester functional group, formulate a considerable synthetic challenge. Williams and Davies failed to independently synthesize this nemesis, however, a ‘two heads are better than one’ approach delivered the first total synthesis of the molecule, since its diamond aniversary isolation.

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