229. Convenient method for the functionalization of the 4- and 6-positions of the androgen skeleton

Authors: Daniel Morton,   Allison R. Dick,   Debashis Ghosh and   Huw M. L. Davies

Chem. Commun.,

2012, 48, 5838-5840


The preparation and reactivity of steroidal vinyldiazo compounds is reported, providing a convenient, substituent tolerant, chemo- and stereoselective entry into 4- and 6-substituted androgen analogues from a common precursor. Under dirhodium catalysis, O–H insertion occurs at the carbenoid site, leading to 4-substituted steroids, but under silver catalysis, O–H insertion occurs at the vinylogous position, leading to 6-substituted steroids.

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