{"id":2,"date":"2017-11-06T02:32:00","date_gmt":"2017-11-06T02:32:00","guid":{"rendered":"http:\/\/scholarblogs.emory.edu\/koellelab\/?page_id=2"},"modified":"2025-03-05T15:21:52","modified_gmt":"2025-03-05T15:21:52","slug":"home","status":"publish","type":"page","link":"https:\/\/scholarblogs.emory.edu\/koellelab\/","title":{"rendered":"Home"},"content":{"rendered":"<figure id=\"attachment_283\" aria-describedby=\"caption-attachment-283\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-283 size-full\" src=\"http:\/\/scholarblogs.emory.edu\/koellelab\/files\/2025\/03\/Koelle_lab_and_friends_2025.jpg\" alt=\"\" width=\"1200\" height=\"971\" srcset=\"https:\/\/scholarblogs.emory.edu\/koellelab\/files\/2025\/03\/Koelle_lab_and_friends_2025.jpg 1200w, https:\/\/scholarblogs.emory.edu\/koellelab\/files\/2025\/03\/Koelle_lab_and_friends_2025-768x621.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-283\" class=\"wp-caption-text\">Koelle lab and friends, January 2025<\/figcaption><\/figure>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">We study the population and evolutionary dynamics of RNA viruses using quantitative approaches. These quantitative approaches include the development and simulation of mathematical models, as well as statistically fitting these models to data. We further incorporate phylogenetic analyses into our studies to characterize observed patterns of viral evolution. Our focus is on viruses affecting humans, particularly SARS-CoV-2, influenza, and norovirus. We are interested in these dynamics at multiple different scales: at the host population level, at the transmission event, and at the within-host level.<br \/>\n<\/span><\/p>\n<p><span style=\"font-family: helvetica, arial, sans-serif\">Our research program spans several general topics of inquiry: <\/span><\/p>\n<ul>\n<li><span style=\"font-family: helvetica, arial, sans-serif\">Understanding the interplay between viral evolution and the epidemiological spread of viral infectious diseases. Research on this topic focuses on understanding patterns of antigenic and genetic evolution of partially-immunizing viruses such as influenza, where disease spread impacts herd immunity levels, which in turn drive selection pressures on viral evolution.<\/span><\/li>\n<li><span style=\"font-family: helvetica, arial, sans-serif\">Understanding constraints on viral adaptation. We have used both modeling and statistical analyses of viral sequence data to identify factors that limit the ability of viruses such as influenza to adapt to new or changing environments. Some of the factors we have examined include transmission bottlenecks and constraints imposed by genetic linkage.<\/span><\/li>\n<li><span style=\"font-family: helvetica, arial, sans-serif\">Understanding how the genetic and genomic diversity of RNA viruses impacts within-host viral dynamics and onward transmission potential. We have worked on developing modeling approaches to consider how viral diversity within a host interacts to yield collective infection phenotypes, especially in the context of cellular coinfection.<\/span><\/li>\n<li><span style=\"font-family: helvetica, arial, sans-serif\">Understanding interindividual variation in within-host viral dynamics and evolution. Considerable heterogeneity exists across hosts in their susceptibility, infectivity, and response to infection with viral pathogens. With analyses of dengue virus and influenza virus, our group has examined the causes and consequences of this heterogeneity with a focus on how host immune status, as determined by infection history, impacts selection pressures experienced by a viral population within a host.<\/span><\/li>\n<li><span style=\"font-family: helvetica, arial, sans-serif\">Understanding the impact of control measures on the epidemiological and evolutionary dynamics of viral infectious diseases. Our group has contributed to understanding the potential effects of disease control for both dengue virus and influenza virus, with a focus on how vector reduction, immunization, and novel therapeutic control efforts will impact disease burden.<\/span><\/li>\n<li>Developing statistical approaches to improve understanding and prediction of viral circulation across time and space using wastewater data.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>We study the population and evolutionary dynamics of RNA viruses using quantitative approaches. These quantitative approaches include the development and simulation of mathematical models, as well as statistically fitting these models to data. We further incorporate phylogenetic analyses into our studies to characterize observed patterns of viral evolution. Our focus is on viruses affecting humans, &hellip; <a href=\"https:\/\/scholarblogs.emory.edu\/koellelab\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Home<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5028,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/scholarblogs.emory.edu\/koellelab\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scholarblogs.emory.edu\/koellelab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/scholarblogs.emory.edu\/koellelab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/scholarblogs.emory.edu\/koellelab\/wp-json\/wp\/v2\/users\/5028"}],"replies":[{"embeddable":true,"href":"https:\/\/scholarblogs.emory.edu\/koellelab\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":20,"href":"https:\/\/scholarblogs.emory.edu\/koellelab\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":306,"href":"https:\/\/scholarblogs.emory.edu\/koellelab\/wp-json\/wp\/v2\/pages\/2\/revisions\/306"}],"wp:attachment":[{"href":"https:\/\/scholarblogs.emory.edu\/koellelab\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}