Recent Publications

  • “Heteroaromatic Thioether – Boronic Acid Cross-Coupling under Neutral Conditions” by Jiri Srogl and Lanny S. Liebeskind, Org. Lett, 2002, 4(6), 979-981.
  • “A New Catalytic Cross-Coupling Approach for the Synthesis of Protected Aryl and Heteroaryl Amidines” by Carrie L. Kusturin, Lanny S. Liebeskind and William L. Neumann, Org. Lett., 2002, 4(6), 983-985.
  • “Squaric Acid Ester Based Synthesis of Echinochrome A” by Eduardo Pena Cabrera and Lanny S. Liebeskind, J. Org. Chem., 2002, 67, 1689-1691.
  • A New Oxidative Demetalation Protocol for h3-Molybdenum p-Complexes.  Enantiocontrolled Synthesis of Unsaturated Ketones and Lactones” by Ana Alcudia, Ramón Gómez Arrayás and Lanny S. Liebeskind, J. Org. Chem., 2002, 67, 5773-5778.
  • “Bioinspired Organometallic Chemistry” by Lanny S. Liebeskind, Jiri Srogl, Cecile Savarin, and Concepcion Polanco, Pure Appl. Chem., 2002, 74(1), 115-122.
  • “A Mild, Non-basic Synthesis of Thioethers.  The Copper Catalyzed Coupling of Boronic Acids with N-Thio(alkyl, aryl, heteroaryl)imides” by Savarin, Cecile; Srogl, Jiri; Liebeskind, Lanny S. Org. Lett. 2002, 4, 4309-4312.
  • Heteroaromatic Thioether-Organostannane Cross-coupling” by Masahiro Egi and Lanny S. Liebeskind, Org. Lett., 2003, 5, 801-802.
  • “Enantiocontrolled Synthesis of 2,6-Disubstituted Piperidines by Desymmetrization of meso-h-(3,4,5)-Dihydropyridinylmolybdenum Complexes.  Application to the Total Synthesis of (-)-Dihydropinidine and (-)-Andrachcinidine” by Chutian Shu and Lanny S. Liebeskind, J. Am. Chem. Soc., 2003, 125, 2878-2879.
  • “h3-Pyranyl and h3-Pyridinyl Molybdenum p-Complexes as Chiral Scaffolds for the Enantioselective Construction of Substituted Oxa- and Aza[3.3.1]bicyclics: First Enantio- and Regiocontrolled [5+3] Cycloaddition Reactions” by Ramon Gomez Arrayas and Lanny S. Liebeskind, J. Am. Chem. Soc. 2003, 125, 9026-9027.
  • Ketone Synthesis under Neutral Conditions.  Cu(I) Diphenylphosphinite-Mediated, Palladium-Catalyzed Coupling of Thiol Esters and Organostannanes” by Rüdiger Wittenberg, Jiri Srogl, Masahiro Egi, and Lanny S. Liebeskind, Org. Lett. 2003, 5, 3033-3035.
  • Switchable Catalysis: Modular Synthesis of Functionalized Pyrimidinones via Selective Sulfide and Halide Cross-Coupling Chemistry by Carrie Kusturin, Lanny S. Liebeskind*, Kirby Sample, Barbara Schweitzer, Jiri Srogl, and William L. Neumann*, Org. Lett., 2003, 5(23), 4349-4352.
  • Copper-Mediated, Palladium-Catalyzed Coupling of Thiol Esters with Aliphatic Organoboron Reagents” by Ying Yu and Lanny S. Liebeskind, J. Org. Chem., 2004, 69, 3554-3557.
  • “Cu(I) Mediated Reductive Amination of Aryl Boronic Acids with Aryl Nitroso Compounds Under Mild Conditions” by Ying Yu, Jiri Srogl, and Lanny S. Liebeskind, Org. Lett., 2004, 6, 2631-2634.
  • “Palladium-Catalyzed Coupling of Thiol Esters with Aryl and Primary and Secondary Alkyl Organoindium Reagents” by Bryan W. Fausett and Lanny S. Liebeskind, J. Org. Chem. 2005, 70, 4851-4853.
  • “Synthesis of Substituted Oxa- and Aza[3.2.1] and [4.3.1]bicyclics via an Unprecedented Molybdenum-Mediated 1,5-“Michael-Type” Reaction” by Zhang, Y.; Liebeskind, L. S. J. Am. Chem. Soc. 2005, 127, 11258 -11259.
  • “Organometallic Enantiomeric Scaffolding – Organometallic Chirons.  Total Synthesis of (-)-Bao Gong Teng A by a Molybdenum-Mediated [5+2] Cycloaddition”, by Zhang, Y.; Liebeskind, L. S. J. Am. Chem. Soc. 2006, 128, 465-472.  DOI: 10.1021/ja055623xss
  • “Palladium-Catalyzed, Copper(I)-Mediated Coupling of Boronic Acids and Benzylthiocyanate. A Cyanide-Free Cyanation of Boronic Acids” by Zhihui Zhang and Lanny S. Liebeskind, Org. Lett., 2006, 8, 4331-4333. PMCID:  PMC2561219.  DOI: 10.1021/ol061741t
  • “Ambient Temperature Synthesis of High Enantiopurity N-Protected Peptidyl Ketones by Peptidyl Thiol Ester–Boronic Acid Cross-Coupling” by Hao Yang, Hao Li, Rüdiger Wittenberg, Masahiro Egi, Wenwei Huang, and Lanny S. Liebeskind, J. Am. Chem. Soc. 2007, 129, 1132-1140. NIHMSID: NIHMSID98691. PMCID: PMC2652697.  DOI: 10.1021/ja0658719
  • “The Enantiomeric Scaffold Approach to Highly Functionalized 1-Oxadecalines: Enantio- and Regiocontrolled [4+2] Cycloadditions of 5-Alkenyl-h3-Pyranylmolybenum Complexes” by Ramón Gómez Arrayás, Jingjun Yin,and Lanny S. Liebeskind, J. Am. Chem. Soc. 2007, 129, 1816-1825. NIHMSID: NIHMSID99042. PMCID: PMC2758531.  DOI: 10.1021/ja067104fs
  • “N-Substituted Imines by the Copper-Catalyzed N-Imination of Boronic Acids and Organostannanes with O-Acyl Ketoximes” by Songbai Liu, Ying Yu, and Lanny S. Liebeskind, Org. Lett. 2007, 9, 1947-1950. NIHMSID: NIHMSID98693.  PMCID: PMC2652698.  DOI: 10.1021/ol070561ws
  • “A Concise, Scalable Synthesis of High Enantiopurity (-)-D-erythro-Sphingosine Using Peptidyl Thiol Ester-Boronic acid Cross Coupling”, by Hao Yang and Lanny S. Liebeskind, Org. Lett. 2007, 9, 2993-2995. NIHMSID: NIHMSID98690. PMCID: PMC2663357.  DOI: 10.1021/ol070991m
  • “Pd-Catalyzed, Cu(I)-Mediated Cross-Couplings of Bisarylthiocyclobutenediones with Boronic Acid and Organostannanes” by Angélica Aguilar-Aguilar, Lanny S. Liebeskind and Eduardo Peña-Cabrera, J. Org. Chem. 2007, 8539-8542. NIHMSID: NIHMSID98692.  PMCID: PMC2708074  DOI: 10.1021/jo701331ms
  • “A New Paradigm for Carbon-Carbon Bond Formation: Aerobic, Copper-Templated Cross-Coupling” by Janette Villalobos Jiri Srogl, and Lanny S. Liebeskind J. Am. Chem. Soc, 2007, 129, 15734 – 15735. PMCID:  PMC2561227.  DOI: 10.1021/ja074931n
  • “Practical, Scalable, High-Throughput Approaches to h3-Pyranyl and h3-Pyridinyl Organometallic Enantiomeric Scaffolds Using the Achmatowicz Reaction.” by Thomas Coombs, Maurice Dupont Lee IV, Heilam (Harry) Wong, Matthew Armstrong, Bo Cheng, Wenyong Chen, and Lanny S. Liebeskind J. Org. Chem. 2008, 73, 882-888. NIHMSID: NIHMSID98674. PMCID: PMC2652699.  DOI: 10.1021/jo702006z
  • “Organometallic Enantiomeric Scaffolding: General Access to 2-Substituted Oxa- and Azabicyclo[3.2.1]octenes via a Brønsted Acid-catalyzed [5+2] Cycloaddition Reaction” by Ethel C. Garnier and Lanny S. Liebeskind, J. Am. Chem. Soc., 2008, 130, 7449 – 7458. NIHMSID: NIHMSID98673.  PMCID: PMC2757657.  DOI: 10.1021/ja800664v
  • “A Simple, Modular Synthesis of Substituted Pyridines” by Songbai Liu and Lanny S. Liebeskind, J. Am. Chem. Soc., 2008, 130, 6918-6919. NIHMSID: NIHMSID98688. PMCID: PMC2664531.  DOI: 10.1021/ja8013743
  • “ N-Amidation by the Copper-Mediated Cross-coupling of Organostannanes and Boronic Acids with O-Acetyl Hydroxamic Acids” by Zhihui Zhang,Ying Yu and Lanny S. Liebeskind, Org. Lett. 2008, 10 (14), 3005-3008. NIHMSID: NIHMSID98689. PMCID: PMC2664512.  DOI: 10.1021/ol8009682
  • “Synthesis of High Enantiopurity N-Protected a-Amino Ketones by Thiol Ester-Organostannane Cross-Coupling using pH-Neutral Conditions” by Hao Li, Hao Yang, and Lanny S. Liebeskind, Org. Lett., 2008, 10 (19), 4375-4378. NIHMSID: NIHMSID90938.  PMCID: PMC2654251.  DOI: 10.1021/ol8018456
  • “A Cu-Catalyzed, pH-Neutral, Aerobic, Room Temperature Construction of High Enantiopurity Peptidyl Ketones from Peptidic S-Acylthiosalicylamides.” by Lanny S. Liebeskind, Hao Yang, and Hao Li, Angew. Chem., Int. Ed. 2009, 48, 1417-1421. NIHMSID: NIHMSID98675.  PMCID: PMC2790066
  • “Organometallic Enantiomeric Scaffolding.  Sequential Semipinacol / 1,5-“Michael-like” Reactions as a Strategic Approach to Bridgehead-Quaternary Center Aza[3.3.1]Bicyclics: Application to the Total Synthesis of (-)-Adaline” by Thomas C. Coombs, Yongqiang Zhang, Ethel C. Garnier-Amblard, and Lanny S. Liebeskind, J. Am. Chem. Soc. 2009, 131 (3), 876-877. NIHMSID: NIHMSID91331.  DOI: 10.1021/ja808533z
  • “Ceramide Synthase Inhibition by Fumonisin B1 causes Accumulation of 1-Deoxy-sphinganine:  a Novel Category of Bioactive 1-Deoxy-sphingoid Bases and 1-Deoxy-dihydroceramides Biosynthesized by Mammalian Cell Lines and Animals” by Nicholas C. Zitomer, Trevor Mitchell, Kenneth A. Voss, Genevieve S. Bondy, Sarah T. Pruett, Ethel Garnier, Lanny S. Liebeskind, Hyejung Park, Elaine Wang, M. Cameron Sullards, Alfred H. Merrill, Jr.and Ronald T. Riley, J. Biol. Chem. 2009, 284, (8), 4786-4795.  doi:  10.1074/jbc.M808798200PMCID:PMCID2643501
  • “On the Mechanism of the Pd(0)-Catalyzed, Cu(I) Carboxylate-Mediated Thioorganic-Boronic Acid Coupling.  A Non-innocent Role for Carboxylate Ligand”, Djamaladdin G. Musaev and Lanny S. Liebeskind, Organometallics 2009, 28, 4639–4642.  DOI: 10.1021/om900602b.  PMCID: PMC2742425.  NIHMSID: NIHMS134090
  • “Organometallic Enantiomeric Scaffolding.  A Molybdenum-mediated Intramolecular Nucleophilic Ketalization-Demetalation Cascade. Total Synthesis of (1R,2S,5S,7R)-(+)-2-Hydroxy-exo-brevicomin” by Bo Cheng and Lanny S. Liebeskind, Org. Lett., 2009, 11 (16), 3682–3685.  NIHMSID: NIHMSID134654.  PMCID: PMCID2736330,  DOI: 10.1021/ol901523g
  • “A New Reaction Motif: “Homo SN2′-Like” Direct Nucleophilic Addition to Neutral h3-Allylmolybdenum Complexes.  Total Synthesis of the Antimalarial (+)–Isofebrifugine” by Wenyong Chen and Lanny S. Liebeskind, J. Am. Chem. Soc., 2009, 131, 12546–12547; DOI: 10.1021/ja9056322.  NIHMSID: NIHMSID170327.  PMCID: PMC2814099)
  • “Synthesis and Evaluation of Novel Proton Exchange Membranes Containing the Semisquaric Acid Group” by Ken Yoshimura and Lanny S. Liebeskind, Macromolecular Rapid Communications, 2010 Volume 31, Issue 19, pages 1725–1730.  DOI: 10.1002/marc.201000223.  PubMed # 21567587  NIHMSID #419229
  • “Novel Substitutions of 1-Alkoxy- and 1-Arylsulfonyloxy-h3-Allylmolybdenum Complexes.  A Case for h1-Alkenyl Carbene Complexes as Intermediates” by Thomas C. Coombs, Wenwei Huang, Ethel C. Garnier-Amblard, and Lanny S. Liebeskind, Organometallics, 2010, 29(21), 5083-5097.  NIHMSID #219119. PMCID: PMC2992457).  DOI: 10.1021/om100305f
  • “Mobilizing Cu(I) for Carbon-Carbon Bond Forming Catalysis in the Presence of Thiolate.  Chemical Mimicking of Metallothioneins” by Zhihui Zhang, Matthew G. Lindale, and Lanny S. Liebeskind, J. Am. Chem. Soc., 2011, 133, 6403–6410.  dx.doi.org/10.1021/ja200792m. PubMed #21449537.  NIHMSID #298641
  •  “A Novel Synthesis and Biological Evaluation of Enigmols (2-Amino-3,5-Dihydroxyoctadecanes) as Therapeutic Agents for Treating Prostate Cancer” by Dennis Liotta, Ethel Garnier-Amblard, Suzanne Mays, Richard Arrendale, Mark Baillie, Anatoliy Bushnev,  Deborah Culver, Taylor Evers, Jason Holt, Randy Howard, Lanny S. Liebeskind, David Menaldino, Michael Natchus, Harsha Ramaraj, Prabhkar Gruddanti, John Petros, ACS Med. Chem. Lett. 2011, 2, 438–443 DOI: 10.1021/ml2000164
  • Organometallic Enantiomeric Scaffolding.  The Regio- Stereo- and Enantiocontrolled Construction of 2,3,6-Trisubstituted Piperidines and Related Systems from a Common Precursor” by Heilam Wong, Ethel C. Garnier-Amblard and Lanny S. Liebeskind, J. Am. Chem. Soc., 2011, 133 (19), 7517–7527. DOI: 10.1021/ja201012p NIHMSID # 291510  Publ.ID: ja201012p  PMCID: PMC3107969
  • “Stereocontrolled Synthesis of a-Amino-a′-alkoxy Ketones by a Copper-Catalyzed Cross-Coupling of Peptidic Thiol Esters and a-Alkoxyalkylstannanes by Hao Li, Anyu He, John R. Falck, and Lanny S. Liebeskind, Org. Lett. 2011, 13, 3682-3685.  PubMed # 21675755  NIHMSID #419220.
  • “In Situ Carboxyl Activation using a Silatropic Switch.  A Novel Approach to Amide and Peptide Constructions by Wenting Wu, Zhihui Zhang, and Lanny S. Liebeskind, J. Am. Chem. Soc. 2011, 133, 14256–14259.  DOI:  10.1021/ja2065158  NIHMSID: NIHMS319273   PubMed PMID: 21846113; PubMed Central PMCID: PMC3189452
  • “Transition Metal-Catalyzed Desulfitative Coupling of Thioorganic Compounds with Boronic Acids” by Ethel C. Garnier-Amblard and Lanny S. Liebeskind in Boronic Acids: Preparation and Applications in Organic Synthesis, Medicine and Materials, Second Edition. Chapter 7, pages 363-391.  Edited by Dennis G. Hall.2011 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2011 by Wiley-VCH Verlag GmbH & Co. KGaA.
  • “Mechanistic Insights into the Aerobic Cu(I)-Catalyzed Cross-Coupling of S-Acyl Thiosalicylamide Thiol Esters and Boronic Acids” by Adrián Varela-Álvarez, Lanny S. Liebeskind, and Djamaladdin G. Musaev, Organometallics, 2012, accepted.  NIHMSID #419245
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