Issued US Patents

82. Steriod Analogues for Neuroprotection. U.S. Patent 9,527,881. 2016. MacNelvin, C.; Stein, D.; Liotta, D.; Atif, F.; Sayeed, I.; Guthrie, D.; Lockwood, M.; Natchus, M.

81. Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction. U.S. Patent 9,205,085. 2015. Natchus, M.; Arrendale, R.; Liotta, D.

80. 2′-fluoronucleosides. U.S. Patent 9,180,138. 2015. Schinazi, R.; Liotta, D.; Chu, C.; McAtee, J.; Choi, Y.; Lee, K.; Hong, J.

79. NMDA receptor antagonists for neuroprotection. U.S. Patent 9,079,852. 2015. Liotta, D.; Snyder, J.; Traynelis, S.; Wilson, L.; Mosley, C.; Dingledine, R.; Myers, S.; Tahirovic, Y.

78. Chemokine CXCR4 receptor modulators and used related thereto. U.S. Patent 8,969,381. 2015. Wilson, L.; Wiseman, J.; Liotta, D.; Natchus, M.

77. Subunit selective NMDA receptor potentiators for the treatment of neurological conditions. U.S. Patent 8,822,462  2014. Liotta, D.; Traynelis, S.; Santangelo, R.; Garnier; E.

76. Process for preparing 5,7 diaminopyrazolo [1,5-A] pyrimidine compounds. US Patent 8,507,673 2013. Liotta, D.; Snyder, J.; Jogalekar, A.; Barrett, A.; Fuchter, M.; Cook, M.; Kroll, S.

75. NMDA receptor antagonists for neuroprotection. US Patent 8,420,680 2013. Liotta, D.; Snyder, J.; Traynelis, S.; Wilson, L.; Mosley, C.; Dingledine, R.; Tahirovic, Y.; Myers, S.

74. Triptolide analogs for the treatment of autoimmune and inflammatory disorders. US Patent 8,193,249 2012. Liotta, D.; Wang, S.; Snyder, J.; Venkatesan, H.

73. 2-fluoronucleosides. US Patent 8,168,583 2012. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.

72. 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation. US Patent 8,114,994 2012. Liotta, D.; Mao, S.; Hager, M.; Schinazi, R.

71. CXCR4 antagonists for the treatment of medical disorders. US Patent 8,114,884 2012. Liotta, D.; Shim, H.; Snyder, J.; Zhan, W.; Liang, Z.

70. CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders. US Patent 8,080,659 2011. Liotta, D.; Snyder, J. and Zhan, W.

69. Selective inhibitors for cyclin-dependent kinases. U.S. Patent 8,067,424. 2011. Liotta, D.; Jogalekar, A.; Snyder, J.; Barrett, A.; Coombes, R.; Ali, S.; Siwicki, A.; Brackow, J.; Scheiper, B.

68. 2′-fluoronucleosides. U.S. Patent 7,662,938. 2010. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.

67. HIV-1 mutations selected for by .beta.-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine. U.S. Patent No. 7,635,690. 2009. Liotta, D.; Schinazi, R.; Hammond, J.; Mellors, J.

66. Triptolide analogs for the treatment of autoimmune and inflammatory disorders. U.S. Patent No. 7,577,139. 2009. Liotta, D.; Venkatesan, H.; Snyder, J.; Wang, S.

65. 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation. U.S. Patent 7,495,006. 2009. Liotta, D.; Mao, S.; Hager, M.; Schinazi, R.

64. Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 7,468,436. 2008. Liotta, D.; Schinazi, R.; Choi, W.

63. 5-Carboxamido or 5-Fluoro-2’,3’-Unsaturated or 3’-Modified-Pyrimidine Nucleosides. US Patent 7,419,966. 2008. Liotta, D.; Schinazi, R.

62. Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane. U.S. Patent No. 7,402,588. 2008. Liotta, D.; Schinazi, R.; Choi, W.

61. pH-dependent NMDA receptor antagonists. U.S. Patent No. 7,375,136. 2008. Liotta, D.; Traynelis, S.; Snyder, J.; Altas, Y.; Mott, D.; Doherty, Jr, J.; Dingledine, R.

60. Curcumin analogs with anti-tumor and anti-angiogenic properties. U.S. Patent No. 7,371,766. 2008. Liotta, D.; Snyder, R.; Davis, M., Adams, B.; Shoji, M.; Ferstl, E.; Sunay, U.

59. 2′-fluoronucleosides. U.S. Patent 7,307,065. 2007. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.

58. Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 7,160,999. 2007. Liotta, D.; Schinazi, R.; Choi, W.

57. HIV-1 mutations selected for by .beta.-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine. U.S. Patent No. 7,115,584. 2006. Liotta, D.; Schinazi, R.; Hammond, J.; Mellors, J.

56. Therapeutic nucleosides. U.S. Patent No. 7,053,100. 2006. Liotta, D.

55. Process of manufacture of 1,3-oxathiolane nucleosides using titanium trichloride mono-isopropoxide. U.S. Patent No 6,939,965. 2005. Liotta, D.; Painter, G.; Almond, M.; Soria, J.; Sznaidman, M.

54. 2′-fluoronucleosides. U.S. Patent 6,911,424. 2005. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.

53. Therapeutic nucleosides. U.S. Patent No. 6,812,233. 2004. Liotta, D.

52. Triptolide analogs for the treatment of autoimmune and inflammatory disorders. U.S. Patent No. 6,777,441. 2004. Liotta, D.; Wang, E.; Snyder, J.; Venkatesan, H.

51. Diimino compounds for use as modulators of cell regulation. U.S. Patent 6,750,211. 2004. Liotta, D.; Merrill, A.; Warden, L.

50. Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination. U.S. Patent No. 6,720,184. 2004. Liotta, D.; Merrill,Jr., A.; Wang, E.; Riley, R.

49. Method of Resolution and Antiviral Activity of 1,3-Oxathiolane Nucleoside Enantiomers. US Patent 6,703, 396 B1. 2004. Liotta, D.; Schinazi, R.; Choi, W.

48. 3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith. U.S. Patent No. 6,680,303. 2004. Liotta, D.; Schinazi, R.

47. Curcumin analogs with anti-tumor and anti-angiogenic properties. U.S. Patent No. 6,664,272. 2003. Liotta, D.; Snyder, J.; Davis, M.; Adams, B.; Shoji, M.; Ferstl, E.; Sunay, U.

46. Antiviral Activity and Resolution of 2-Hydroxymethyl-5-(5-Fluorocytosin-1-YL)-1,3. US Patent 6,642,245,B1 2003. Liotta, D.

45. Sphingolipid Derivatives and Their Methods of Use. US Patent 6,610,835, 2003. Liotta, D.; Merrill, A.; Keane, T.; Schmelz, E.; Bhalla, K.

44. Method for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent No. 6,583,292. 2003. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.

43. Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,576,776. 2003. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.

42. Diiminopiperazine derivatives for use in the modification of sphingolipid metabolism and as modulators of cell regulation. U.S. Patent 6,552,025, 2003. Liotta, D.; Merrill, A.; Warden, L.

41. Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,518,425. 2003. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.

40. Compositions and Methods for Targeting Phamaceutically Active Materials to Cells Containing Androgen Receptors. US Patent 6,468,981, 2002. Liotta, D.; Petros, J.

39. Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent No. 6,399,783. 2002. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.

38. 5-Carboxamido or 5-Fluoro-2’,3’-Unsaturated or 3’-Modified-Pyrimidine Nucleosides. US Patent 6,391,859, 2002. Liotta, D.; Schinazi, R.

37. 2′-Fluoronucleosides. U.S. Patent No. 6,348,587. 2002. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.

36. Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers. U.S. Patents 6,346,627. 2002. Liotta, D.; Schinazi, R.; Choi, W.

35. Treatment of HIV by administration of .beta.-D-2′, 3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (D4FC). U.S. Patent No. 6,232,300. 2001. Liotta, D.; Schinazi, R.

34. Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,215,004. 2001. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.

33. Method and compositions for the synthesis of BCH-189 and related compounds. U.S. Patent No. 6,153,751. 2000. Liotta, D.; Choi, W.

32. Polycationic oligomers. U.S. Patent No. 6,153,596. 2000. Liotta, D.; Petros, J.; Wey, S.; Karr, J.; Pohl, J.

31. Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent 6,150,537. 2000. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.

30. Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination. U.S. Patent No 6,127,578. 2000. Liotta, D.; Merrill Jr., A.; Wang, E.; Riley, R.

29. Antiviral activity and resolution of 2-hydroxymethyl-5-(5-flurocytosin-1-yl)-1,3-oxathiolane. U.S. Patent No. 6,114,343. 2000. Liotta, D.; Schinazi, R.; Choi, W.

28. Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 6,069,252. 2000. Liotta, D.; Schinazi, R.; Choi, W.

27. Diastereoselective synthesis hydroxyethylene dipeptide isosteres. U.S. Patents No. 5,990,341. 1999. Liotta, D.; Lagu, B.

26. Method and compositions for the synthesis of BCH-189 and related compounds. U.S. Patent No. 5,914,400. 1999. Liotta, D.; Choi, W.

25. Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane. U.S. Patents 5,914,331. 1999. Liotta, D.; Schinazi, R.; Choi, W.

24. [5–Caboxamido or 5–fluoro]–[2′, 3′–unsaturated or 3′–modified]–pyrimidine nucleosides. U. S. Patent No. 5,905,070. 1999. Liotta, D.; Schinazi, R.

23. Treatment of Urogenital Cancer with Boron Neutron Capture. U.S. Patent 5,872,107, 1999. Liotta, D.; Schinazi, R.; Keane, T.

22. Method of Resolution and Antiviral Activity of 1.3-Oxathiolane Nucleoside Enantiomers. U.S. Patent 5,892,025, 1998. Liotta, D.; Schinazi, R.; Choi, W.

21. Antiviral 1.3-Dioxolane Nucleoside Analogues. U.S. Patent 5,852,027, 1998. Liotta, D.

20. Method of resolution of 1,3-oxathiolane nucleoside enantiomers. U. S. Patent 5,827,727. 1998. Liotta, D.; Schinazi, R.; Choi, W.; Cheng, Y.

19. Method for the synthesis, compositions and use of 2′-deoxy-5-fluoro-3′-thiacytidine and related compounds. U.S. Patent 5,814,639. 1998. Liotta, D.; Schinazi, R.; Choi, W.

18. Method of Resolution of 1,3-Oxathiolane Nucleoside Enantiomers. US Patent 5,728,575, 1998. Liotta, D.; Choi, W.

17. Compositions Containing 5-Fluoro-2’,3’-Didehydro-2’,3’-Dideoxycytidine Or A Mon-, Di-, Or Triphosphate Thereof And A Second Antiviral Agent. US Patent 5703058, 1997. Liotta, D.; Schinazi, D.

16. Method for the Synthesis, Composition and Use of 2′-Deoxy-5-Fluoro-3′-Thiacyctidine and Related Compounds. U.S. Patent. 5,700,937, 1997. Liotta, D.; Choi, W.; Schinazi, R.

15. One Vessel Stereoselective Glycosylation of Purines and Pyrimidines. U. S. Patent 5,602,245, 1997. Wurster, J.; Wang, J.; Wilson, L.

14. Treatment of urogenital cancer with boron neutron capture therapy. U.S. Patent 5,599,796. 1997. Liotta, D.; Schinazi, R.; Keane, T.

13. Diastereoselective synthesis of hydroxyethylene dipeptide isosteres. U.S. Patent 5,587,514. 1996. Liotta, D.; Lagu, B.

12. Method and Composition for the Synthesis of BCH-189 and Related Compounds. European Patent 5,539,116, 1996. Liotta, D.; Choi, W.

11. 4-Arylisoindole Analgesics. U.S. Patent 5,508,424 , 1996. Liotta, D.; Carmosin, R.; Carson, J.; Pitis, P.; Raffa, R.

10. Sensitizing agents for use in boron neutron capture therapy. U.S. Patent No. 5,462,724. 1995. Liotta, D.; Schinazi, R.

9. Preparation of 3’-Substituted-2’,3’-Dideoxynucleosides and 2’-Deoxynucleosides from Acyclic, Achiral Precursors. U. S. Patent No. 5,432,273 , 1995. Liotta, D.; Hager, M.

8. Preparation of 3’-Substituted-2’,3’-Dideoxynucleosides and 2’-Deoxynucleosides from Acyclic, Achiral Precursors. U. S. Patent No. 5,414,078 , 1995. Liotta, D.; Hager, M.

7. Novel Sensitizing Agents for Boron Neutron Capture Therapy. U.S. Patent No. 5,405,598, 1995. Liotta, D.; Schinazi, R.

6. Methods of Synthesis of 1,3-Dioxolane Nucleosides. U. S. Patent No. 5,276,151, 1994. Liotta, D.

5. Method of Altering Sphingolipid Metabolism and Detecting Fumonisin. U.S. Patent 5,232,837, 1993. Liotta, D.

4. Methods for the Synthesis, Composition and Use of 2′-Deoxy-5-Fluoro-3′-Thiacytidine and Related Compounds. U. S. Patent No. 5,210,085 1993. Liotta, D.; Schinazi, R.; Choi, W.

3. Method and Compositions for the Synthesis of BCH-189 and Related Compounds. U. S. Patent No. 5204466 , 1993. Liotta, D.; Choi, W.

2. Method of Preparing Sphingosine Derivatives. U. S. Patent 5,110,987, 1992. Liotta, D.; Merrill, A

  1. 1,2-1,4 Addition Reaction Sequence Leading to Diphenylacetylenes. U.S. Patent 4,772,755 1988. Liotta, D.; Maryanoff, C.; Paragamian, V.