Publications

276. Kaiser, T.M.; Kell, S.A.; Kusumoto, H.; Shaulsky, G.; Bhattacharya, S.; Epplin, M.P.; Stong, K.L.; Miller, E.J.; Cox, B.D.; Menaldino, D.S.; Liotta, D.C.; Traynelis, S.F.; Burger, P.B. The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor. Molecular Pharmacology, 2017, [Epub ahead of print]

275. Swanger, S.A.; Vance, K.M.: Acker, T.M.; Zimmerman, S.S.; DiRaddo, J.O.; Myers, S.J.; Bundgaard, C.; Mosley, C.A.; Summer, S.L.; Menaldino, D.S.; Jensen, H.S.; Liotta, D.C.; Traynelis, S.F. A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons. ACS Chem Neuroscience, 2017, Nov 2. [Epub ahead of print]

274. Strong, K.L.; Epplin, M.P.; Bacsa, J.; Butch, C.J.; Burger, P.B.; Menaldino, D.S.; Traynelis, S.F., Liotta D.C. The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors. Journal of Medicinal Chemistry, 2017, 60 (13), 5556-5585.

273. Perszyk, R.; Ogden, K.; Strong, K.; Liotta, D.; Traynelis, S. Channel Open Probability Controls Allosteric Modulation of Potency and Efficacy. Biophysical Journal. 2017, 112(3), 420a – 421a.

272. Aldrich, C.; Bertozzi, C.; Georg, G.; Kiessling, L.; Lindsley, C.; Liotta, D.; Merz, K.; Schepartz,  A.; Wang, S. The Ecstasy and Agony of Assay Interference Compounds. ACS Chemical Biology. 2017, 12 (3), 575-578.

271. Jiménez-Somarribas, A.; Mao, S.; Yoon, JJ.; Weisshaar, M.; Cox, R.; Marengo, J.; Mitchell, D.;  Morehouse, Z.; Yan, D.; Solis, I.; Liotta, D.; Natchus, M.; Plemper, R. Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex. Journal of Medicinal Chemistry. 2017, 60 (6), 2305-2325.

270.   Kim, M.; Giesler, K.; Tahirovic, Y.; Truax, V.; Liotta, D.; Wilson, L. CCR5 Receptor Antagonists in Preclinical to Phase II Clinical Development for Treatment of HIV. Expert Opinion on Investigational Drugs. 2016, 25(12), 1377-392.

269. Liotta, D.; Painter, G. Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva). Accounts of Chem Res. 2016, 49(10), 2091-2098.

268. Giesler, K.; Marengo. J.; Liotta, D. Reduction Sensitive Lipid Conugates of Tenofovir: Synthesis, Stability, and Antiviral Activity. J. Med. Chem. 2016, 59(15), 7097-7110.

267. Wall, B; Sayeed, I.; Guthrie, D.; Natchus, M.; Turan, N.; Liotta, D.; Stein, D. Evaluating the neurotherapeutic potential of water-soluble progesterone analog after traumatic brain injury in ratsNeuropharma. 2016, 109:148-158.

266. Pippin, A.; Mohd Arshad, Z.; Voll, R.; Nye, J.; Ghassabian, S.; Williams, C.; Manicini, A.; Liotta, D.; Smith, M.; Goodman, M. In Vitro Metobolic Stability and in Vivo Biodistribution of 3-Methyl-4-furoxancarbaldehyde Using PET Imaging in Rats. ACS Med. Chem. Lett., 2016, 7(6): 563-567

265. Miller, E.; Mays, S.; Baillie, M.; Howard, R.; Culver, D.; Saindane, M.; Ruett, S.; Holt, J.; Menaldino, D.; Evers, T.; Reddy, P.; Arrendale, R.; Natchus, M.; Petros, J; Liotta, D. Discovery of fluorinated enigmol analog with enhanced in vivo pharmacokinetic and anti- tumor properties. ACS Med. Chem. Lett. 2016. ASAP.

264. Katzman, B.; Perszyk, R.; Yuan, H.; Altas Tahirovic, Y.; Sotimehin, A.; Traynelis, S.; Liotta, D. A novel class of negative allosteric modulators of NMDA receptor function. Bioorg. Med. Chem. Lett., 2015, 25:5583-5588.

263. Cox, B.; Mehta, A.; DiRaddo, J.; Liotta, D.; Wilson, L.; Snyder, J. Structural analysis of CXCR4 – Antagonist interactions using saturation-transfer double-difference NMR. Biochem and Biophysical Research Communications 2015, http://dx.doi.org/10.1016/j.bbrc.2015.08.084.

262. DiRaddo, J.; Miller, E.; Bowman-Dalley, C.; Wroblewska, B.; Javidnia, M.; Grajkowska, E.; Wolfe, B.; Liotta, D.; Wroblewski, J. Chloride is an agonist of group II and III metabotropic glutamate receptorsMol Pharmacol , 2015, 88:450-459.

261. Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Sarkaria, J.; Snyder, J.; Liotta, D.; Brat, D.; El-Rayes, B.; Shoji, M. Visualizing cancer and response to therapy in vivo by using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. J. Drug Targeting, 2015, 23(3): 257-265.

260. Cox, B.; Prosser, A.; Sun, Y.; Li, Z.; Lee, S.; Huang, M.; Bond, V.; Snyder, J.; Krystal, M.; Wilson, L.; Liotta, D. Pyrazolo-Piperidines Exhibit Dual Inhibition ofCCR5/CXCR4 HIV Entry and Reverse Transcriptase. ACS Med. Chem. Lett. 2015, 6: 753-757.

259. Zhao, H.; Prosser, A.; Liotta, D.; Wilson, L. Discovery of novel N-aryl piperazine CXCR4 antagonists. Bioorg. & Med. Chem. Lett. 2015, 25: 4950-4955.

258. Yuan, H.; Myers, S.; Wells, G.; Nicholson, K.; Swanger, S.; Lyuboslavsky, P.; Tahirovic, Y.; Menaldino, D.; Ganesh, T.; Wilson, L.; Liotta, D.; Snyder, J.; Traynelis, S. Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects. Neuron., 2015, 85: 1305-1318.

257. Baldwin, P.; Reeves, A.; Powell, K.; Napier, R.; Swimm, A.; Sun, A.; Giesler, K.; Bommarius, B.; Shinnick, T.; Snyder, J.; Liotta, D.; Kalman, D. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis. Eur. J. of Med. Chem., 2015, 92: 693-699.

256. Khatri, A.; Burger, P.; Swanger, S.; Hansen, K.; Zimmerman, S.; Karakas, E.; Liotta, D.; Furukawa, H.; Snyder, J.; Traynelis, S. Structural Determinants and Mechanism of Action of GluN2C-selective NMDA Receptor Positive Allosteric Modulator. Mol. Pharmacol., 201486:548–560.

255. Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Liotta, D.; El-Rayes, B.; Brat, D.; Snyder, J.; Shoji, M. Tumor Angieogenesis Therapy Using Targeted Delivery of Pacclitaxel to the Vasculature of Breast Cancer Metastases. J. Drug Deliv., 2014

254. Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Sarkaria, J.; Snyder, J.; Liotta, D.; Brat, D.; El-Rayes, B.; Shoji, M. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. J. Drug Target. 2014, 16:1-9.

253. Strong, K.; Jing, Y.; Prosser, A.; Traynelis, S.; Liotta, D. NMDA receptor modulators: an updated patent review (2013-2014). Expert Opin. Ther. Patents., 2014, 24(12), 1349-1366.

252.  Zhou, T.; Ye, L.; Bai, Y.; Sun, A.; Cox, B.; Liu, D.; Li, Y.; Liotta, D.; Snyder, J.; Fu, H. Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: A novel curcumin analog. PLoS One., 2014, 9 (9), e107876

251. DiRaddo, J.; Miller, E.; Hathaway, H.; Grajkowska, E.; Wroblewska, B.; Wolfe, B.; Liotta, D.; Wroblewski, J. A Real-Time Method for Measuring cAMP Production Modulated by Gαi/o-Coupled Metabotropic Glutamate Receptors. J. Pharmacol.Exp. Ther., 2014, 349(3), 373–382.

250. Hu, H.; Mao, S.; Bugrysheva, J.; Pruett, S.; Liotta, D.; Scott, J.; Snyder, J. Group A streptococcus inhibitors by high-throughput virtual screening. Eur. J. of Med. Chem., 2014, 82, 120-126.

249. Cox, B.; Prosser, A.; Katzman, B.; Alcaraz, A.; Liotta, D.; Wilson, L.; Snyder, J. Anti-HIV Small Molecule Binding in the Peptide Subpocket of the CXCR4:CVX15 Crystal Structure. Chem. BioChem. 2014, 15(11), 1614-1620.

248. Krumm S. A.; Yan, D.; Hovingh, E.; Evers, T. J.; Enkirch, T.; Prabhakar R.; Sun, A.; Manohar T.; Arrendale, R.; Painter, G.; Liotta, D..; Natchus, M.; von Messling, V.; Plemper, R. An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model. Sci. Transl. Med2014, 6(232), p. 232ra52.

247. Zimmerman, S.; Khatri, A.; Garnier-Amblard, E.; Mullasseril, P.; Kurtkaya, N.; Gyoneva, S.; Hansen, K.; Traynelis, S.; Liotta, D. Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators. J. Med. Chem2014, 57 (6), 2334-2356.

246. Prosser, A.; Liotta, D. One-pot transformation of esters to analytically pure ketones: methodology and application in process development. Tet. Lett. 2014. Article in Press.

245.  Truax, V.; Zhao, H.; Katzman, B.; Prosser, A.; Alcaraz, A..; Saindane, Manohar T.; Howard, R.; Culver, D.; Arrendale, R.; Gruddanti, P., Taylor J.E., Natchus, M.; Snyder, J.; Liotta, D.; Wilson, L. Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists. ACS Med. Chem. Lett. 2013, 4(11), 1025- 1030.

244.  Acker,T.; Khatri, A.; Vance, K.; Slabber, C.; Bacsa, J.; Snyder, J.; Traynelis, S.; Liotta, D. Structure-Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Page 39 Class of GluN2C/GluN2D Selective Antagonists. J. Med. Chem. 2013, 56(16), 6434-6456.

243.  Moore, T.; Sana, K.; Yan, D.; Krumm, S.; Thepchatri,P.; Snyder, J.; Marengo, J.; Arrendale, R.; Prussia, A.; Natchus, M.; Liotta, D. Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy. ACS Med. Chem. Lett2013, 4(8), 762-767.

242. Santangelo Freel, R.; Ogden, K..; Strong, K..; Khatri, A.; Chepiga, K..; Jensen, H.; Traynelis, S.; Liotta, D. Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-D-aspartate Receptors. J. Med. Chem2013, 56(13), 5351-5381.

241. Brown, A.; Shi, Q.; Moore, T.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.; Shim, H.; Snyder, J. Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors That Mediate Anticancer Properties. J. Med. Chem2013, 56(9), 3456-3466.

240. Moore, T.; Sana, K.; Yan, D.;Thepchatri, P.;Ndungu, J.;Sandaine, M.; Lockwood, M.; Natchus, M.; Liotta, D.;Plemper, R.; Snyder, J.; Sun, A. Asymmetric synthesis of host-directed inhibitors of myxovirus. Bellstein J. Org. Chem2013, 9(23), 197-203.

239. Shi, Q.; Moore, T.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.; Shim, H.; Brown, A.; Snyder, J. Monocarbonyl Curcumin Analogs: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anti-Cancer Properties. J. Med. Chem2013, 56 (9), 3456-3466.

238. Kim, J.; Wang, L.; Li, Y.; Becnel, K.; Frey, K.; Garforth, S.; Prasad, V.; Schinazi, R.; Liotta, D.; Anderson, K. Pre-steady State Kinetic Analysis of Cyclobutyl derivatives of 2’-deoxyadenosine 5’-triphosphate as inhibitors of HIC-1 transcriptase. Bioorg. Med. Chem. Lett2012, 22(12), 4064-4067.

237.  Hassam, M., Basson, A., Liotta, D.; Morris, L.; van Otterlo, W.; Pelly, S. Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transctiptase Inhibitors. ACS Med. Chem. Lett2012, 3(6), 470-475.

236. Guthrie, D.; Stein, D.;  Liotta, D.; Lockwood, M.; Sayeed, I.; Atif, F.; Arrendale, R.; Reddy, P.; Evers, T.; Marengo, J.; Howard, R.; Culver, D.; Natchus, M. Water-Soluble Progesterone Analogues are Effective,Injectable Treatments in Animal Models of Traumatic Brain Injury. ACS Med. Chem. Lett., 2012, 3(5), 362-366.

235. Burger, P.; Yuan, H.; Karakas, E.; Geballe, M.; Furkawa, H.; Liotta, D.; Snyder, J.; Traynelis, S. Mapping the binding of GluN2B-selectve N-methyl-D-aspartate receptor negative allosteric modulators. Mol. Pharmacol. 2012, 82(2), 344-359.

234. Santangelo, R.; Acker, T.; Zimmerman, S.; Katzman, B.; Strong, K.; Traynelis, S.; Liotta, D. Novel NMDA Receptor Modulators: An Update. Expert Opin. Ther. Pat. 2012, 22(11), 1337-1352.

233. Meyer, E.; Holt,J.;  Girard, K.; Baillie, M.; Bushnev, A.; Lapp, S.; Menaldino, D.; Arrendale, R.; Reddy, P.; Evers, T.; Liotta, D.; Galinski, M.; Natchus, M. Sphingolipid Analogues Inhibit Development of Malaria Parasites. ACS Med. Chem. Lett. 2012, 3(1),43-47.

232. Liang, Z.; Zhan, W.; Zhu, A.; Yoon, Y.; Lin, S.; Sasakim Jan, M.; Klapproth, M.; Yang, H.; Grossniklaus, H.; Xu, J.; Yun, C.; Snyder, J.; Liotta, D.; Shim, H. Development of a Unique Small Molecule Modilator of CXCR4. PLoS one 2012, 7(4), e34038.

231. Ndungu, J.; Krumm, S.; Yan, D.; Arrendale, R.; Reddy, P.; Evers, T.; Howard, R.; Natchus, M.; Sandaine, M.; Liotta, D.; Plemper, R.; Snyder, J.; Sun, A. Non-nuceoside Inhibitors of the Measles Virus RNA-dependent RNA Polymerase: Synthesis, Structure- Activity Relationships and Pharmacokinetics. J. Med. Chem. 2012, 55, 4220−4230.

230. Olivera, A.; Moore, T.;Hua, F.; Brown, A.; Sun, A.; Liotta, D.; Snyder, J.; Yoon, Y.; Shim, H.; Marcus, A.; Miller, A.; Pace, T. Inhibition of the NF-signaling pathway by the curcumin analog, 3,5-Bis(,2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int. Immunopharmacol. 2012,12(2), 368-377.

229.  Boyle, G.; Edlin, C.; Li, Y.; Liotta, D.; Morgans, G.; Musondaa, C. Enantioselective Synthesis of the Carbocyclic Nucleoside (–)-Abacavir. Org. Biomol. Chem. 2012, 10(9), 1870-1876.

228. Makarova, N.; Zhao, C.; Zhang, Y.; Bhosle, S.; Suppiah, S.; Rhea, J.; Kozyr, N.; Arnold, R.; Ly, H.; Molinaro, R.; Parslow, T.; Hunter, E.; Liotta, D.; Petros, J.; Blackwell, J. Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model. PLoS one 2011, 6(4), e18272.

227. Zhan, W.; Jiang, Y.; Sharma, S.; Brodie, P.; Bane, S.; Kingston, D.; Liotta, D.; Snyder, J. C6-C8 Bridged Epothilones: Consequences of Installing a Conformational Lock at the Edge of the Macrocycle Chem. Eur. J. 2011, 17(52), 4792-14804.

226. Wilson, L.; Liotta, D.Emergence of small-molecule CXCR4 antagonists as novel immune and hematopoietic system regulatory agents. Drug Develop. Res. 2011, 72(7), 598-602.

225. Symolon, H.; Bushnev, A.; Peng, Q.; Ramaraju, H.; Mays, S.; Allegood, J.; Pruett, S.; Sullards, M.; Dillehay, D.; Liotta, D., Merrill, A. Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In vivo Models for Intestinal and Prostate Cancer. Mol. Cancer Ther. 2011, 10(4), 648-657.

224.  Acker, T.; Yuan, H.; Hansen, K.; Vance, K.; Ogden, K.; Jensen, H.; Burger, P.; Mullasseril, P.; Snyder, J.; Liotta, D., Traynelis, S. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunitselective  modulators. Mol. Pharmacol. 2011, 80(5), 782-795.

223. Garnier-Amblard, E.; Mays, S.; Arrendale, R.; Baillie, M.; Bushnev, A.; Culver, D.; Evers, T.; Holt, J.; Howard, R.; Liebeskind, L.; Menaldino, D.; Natchus, M.; Petros, J.; Ramaraju, H.; Reddy, P.; Liotta, D. Novel Synthesis and Biological Evaluation of Enigmols as Therapeutic Agents for Treating Prostate Cancer. ACS Med. Chem. Lett. 2011, 2(6), 438-443.

222. Bushnev, A.; Baillie, M.; Holt, J.; Menaldino, D.; Merrill, A.; Liotta, D. An efficient asymmetric synthesis of enigmols (1-deoxy-5-hydroxysphingoid bases), an important class of bioactive lipid modulators. ARKIVOC (Gainesville, FL, United States) 2010, (8), 263-277.

221. Pandey, K.; Snyder, J.; Liotta, D.; Musaev, D. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein. J. Phys. Chem. B (2010), 114(2), 1127-1135.

220. Zhu, A.; Zhan, W.; Liang, Z.; Yoon,Y.; Yang, H.; Grossniklaus, H.; Xu, J.; Rojas, M.; Lockwood, M.; Snyder, J.; Liotta, D.; Shim, H. Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity. J. Med. Chem. 2010, 53 (24), 8556-8568.

219. Heathcote, D.; Petal, H.; Kroll, S.; Hazel, P.; Periyasamy, M.; Alikian, M.; Kanneganyi, S.; Jogalekar, A.; Scheiper, B.; Bräckow, J.; Siwicka, A.; Pace, R.; Fuchter, M.; Snyder, J.; Liotta, D.; Freemont, P.; Aboagye, E.; Coombes, R.; Barrett, A.; Ali, S. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2 and 9, which demonstrates anti-tumour effects in human tumour xenografts following oral administration. J.Med. Chem. 2010, 53 (24), 8508-8522.

218. Thomas, S.; Zhao, J.; Li, Z.; Lou, B.; Du, Y.; Purcell, J.; Snyder, J.; Khuri, F.; Liotta, D.; Fu, H. Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochem. Pharmacol., 2010, 80 (9), 1309-1316.

217. Xin, T.; Sidell, N.;  Mancini, A.; Huang, R.; Wang, S.; Horowitz , I.; Liotta, D.; Taylor, R.; Friedrich, W. Multiple Anticancer Activities of EF24, a Novel Curcumin Analog, on Human Ovarian Carcinoma Cells. Reprod. Sci. 2010, 17 (10), 931-40.

216. Mullasseril, P.; Hansen, K.; Vance, K.; Ogden, K.; Yuan, H.; Kyrtkaya, N.; Santangelo, R.; Orr, A.; Le, P.; Vellano, K.; Liotta, D.; Traynelis, S. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat.Commun2010, 1 (90).

215. Suppiah, S.; Sun, C.; Zhang, X.; Bhosle, S.; Rhea, J.; Mays, S.; Parslow, T.; Arnold, R.; Makarova, N.; Liotta, D.; Hunter, E.; Blackwell, J.;Petros, J.; Ly, H.; Molinaro, R. A Novel Transforming Gene Product of the Xenotropic Murine Leukemia Virus-Related Virus. Submitted.

214. Arnold, R.; Makariva, N.; Osunkoya, A.; Suppiah, S.; Scott, T.; Johnson, N.; Bhosle, S.; Liotta, D.; Hunter, E.; Marshall, F. XMRV infection in patients with prostate cancer; novel serologic assay and correlation with PCR and FISH. J Urol. 2010, 75(4), 755-61.

213. Pandey, K.; Snyder, J.; Liotta, D.; Musaev, D. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein (PrP). J. Phys. Chem. B2010, 114(2), 1127-1135.

212. Li, Y.; Soni, P., Liotta, D.; Liu, L.; Zhang, X.; Lutz, S. Synthesis of fluorescent nucleoside analogs as probes for 2’-deoxyribonucleoside kinases. Bioorg. Med. Chem. Lett.  2010, 20(3), 841-843.

211. Sun, A.; Lu, Y.; Hu, H.; Shoji, M.; Liotta, D.; Snyder, J. Curcumin analog cytotoxicity against breast cancer cells: Exploitation of a redox-dependent mechanism. Bioorg. Med. Chem. Lett. 2009, 19 (23), 6627-6631.

210. Bhosle, S.; Suppiah, S.; Molinaro, R.; Liang, Y.; Arnold, R.; Petros, J.; Diehl, W.; Makarova, N.; Blackwell, J.; Petros, J.; Liotta, D.;Hunter, E.; Ly, H. Evaluation of cellular determinants required in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells. J. Virol. 2010, 84(13), 6288-96.

209. Liu, L.; Li, Y.; Liotta, D.; Lutz, S. Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting. Nucleic Acids Res2009, 37(13), 4472-4481.

208. Mosley, C.; Wilson, L.; Wiseman, J.; Skudlarek, Liotta, D.; Jason, W. Recent patents regarding the discovery of small molecule CXCR4 antagonists. Expert Opin. Ther. Patents 2009, 19(1), 23-28.

207. Ali, S.; Heathcote, D..; Kroll, S.; Jogalekar, A.; Scheiper, B.; Patel, H.; Brackow, J.; Siwicka, A.; Fuchter, M.; Periyasamy, M.; Tolhurst, R.; Kanneganti, S.; Snyder, J.; Liotta, D.; Aboagye, E.; Barrett, A.; Coombes, R. The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity. Cancer Res. 2009, 69(15), 6208-6215.

206. Mosley, C.; Myers, S.; Murray, E.; Santangelo, R.; Tahirovix, Y.; Kurtkaya, N.; Mullasseril, P.; Yuan, H.; Lyuboslavsky, P.; Le, P. Wilson, L.; Yepes, M.; Dingledine, R.; Traynelis, S.; Liotta, D. Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. Bioorganic Med. Chem2009, 17(17), 6463-6480.

205. MacNevin, C.; Atif, F.; Sayeed, I.; Stein, D.; Liotta, D. Development and Screening of Water-Soluble Analogues of Progesterone and Allopregnanolone in Models of Brain Injury. J. Med. Chem2009, 52(19), 6012-6023.

204. Kasinski, A.; Du, Y.; Thomas, S.; Zhao, J.; Sun, S.; Khuri, F.; Wang, C.; Shoji M., Sun, A.; Snyder, J.; Liotta, D.; Fu, H. Inhibition of IKB Kinase-Nuclear Factor-KB Signaling Pathway by 3,5-Bis-(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin. Mol. Pharmacol. 2009, 74 (3), 654-661.

203. Thomas, S.; Zhong, D.; Zhou, W.; Malik, S.; Liotta, D.; Snyder, J.; Hamel, E.; Giannakakou, P. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle 2008, 7:1, 2409-2417.

202.  Thepchatri, P.; Min, J.; Ganesh, T.; Du, Y.; Lewis, I.; Kurtkaya, S.;  Prussia, A.; Li, L.; Plemper, R.; Fu, H.; Liotta, D.; Snyder, J.; Dingledine, R. Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining. Curr. Med. Chem2009, 9 (13), 1159-1171.

201. Pruett, S.; Bushnev, A.; Hagedorn, K.; Adiga, M.; Haynes, C.; Sullards, M.; Liotta, D.; Merrill, A. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols. J. Lipid Res. 2008, 49: 1621-39.

200. Liu, L.; Li, Y.; Liotta, D.; Lutz, S. Directed evolution of an orthogonal nucleoside analog kinase via fluorescence activated cell sorting. Nucleic Acids Res2009, 1-10.

199. Tahirovic, Y.; Geballe, M.; Gruszecka-Kowalik, E.; Myers, S.; Lyuboslavsky, P.; Le, P.; French, A.; Irier, H.;  Choi, W.; Easterling, K.; Yuan, H.; Wilson, L.; McNamara, J.; Dingledine, R.; Liotta, D.; Traynelis, S.; Snyder, J.  Enantiomeric propanolamines as selective N-methyl-Daspartate 2B receptor antagonists. J. Med.Chem2008, 51(18), 5506-5521

198. Shoji, M.; Sun, A.; Kisiel, W.; Lu,Y.; Shim, H.; McCarey, B.; Nichols, C.; Parker, E.; Pohl, J.; Mosley, C.; Alizadeh, A.; Liotta, D.; Snyder, J. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa.), Journal of Drug Targeting, 2008 16:3, 185-197.

197. MacNevin, C.; Moore, R.; Liotta, D. Stereoselective Synthesis of Quaternary Center Bearing Azetines and Their β-Amino Acid Derivatives. J. Org. Chem. 2008, 73(4), 1264-1269.

196. Zhan, W.; Jiang, Z.; Brodie, P.; Kingston, D.; Liotta, D.; Snyder, J. Design and Synthesis of C6-C8 Bridged Epothilone A. Org. Lett. 2008, 10(8), 1565-1568.

195. Shoji, M.; Sun, A.; Kisiel, W.; Lu, Y.; Shim, H.; McCarey, B.; Nichols, C.; Parker, E.; Pohl, J.; Mosley, C.; Alizadeh, A.; Liotta, D.; Snyder, J. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. Journal of Drug Targeting 2008, 16(3), 185-197.

194. MacNevin, C.; Moore, R.; Liotta, D. Stereoselective Synthesis of Quaternary Center Bearing Azetines and their B-amino Acid Derivatives. J. Org. Chem. 2008, 73, 1264-69.

193. Zhan, W.; Liang, Z.; Zhu, A.; Kurtkaya, S.; Shim, H.; Snyder, J.; Liotta, D. Discovery of Small Molecule CXCR4 Antagonists. J. Med. Chem. 2007, 50(23), 5655-5664.

192. Li, Y.; Mao, S.; Hager, M.; Becnel-Davis, K.; Schinazi, R.; Liotta, D. Synthesis and Evaluation of 2′-Substituted Cyclobutyl Nucleosides and Nucleotides as Potential Anti-HIV Agents. Biooorg. Med. Chem. Lett. 2007,17(12), 3398-3401.

191. Wiseman, J.; McDonald, F.; Liotta, D. 1-Deoxy-5-hydroxysphingolipids as new anticancer principles: an efficient procedure for stereoselective syntheses of 2-amino-3,5-diols. Org. Lett. 2007, 9(15), 2959.

190. Mosley, C.; Liotta, D.; Snyder, J.; Aggarwal, B.; Surh, B.; Shishoda, Y.; Eds, S. Highly Active Anti-Cancer Curcumin Analogs. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease 2007, Vol. 595, pp. 77-103.

189. Herold-Dublin, M.; Liotta, D. Diastereoselective Addition of Chlorotitanium Enolates of N-Acyl Thiazolidinethione to Activated Imines: A Novel Synthesis of β-Lactams. Can. J. Chem. 2006, 84(12), 1696-1699.

188. Sun, A.; Prussia, A.; Zhan, W.; Murray, E.; Doyle, J.; Cheng, L.; Yoon, J.; Radchenko, E.; Palyulin, V.; Compans, R.; Liotta, D.; Plemper, R.; Snyder, J. Nonpeptide Inhibitors of Measles Virus Entry. J. Med. Chem. 2006, 49(17), 5080-5092.

187.  Sun, A.; Shoji, M.; Lu, Y.; Yang, J.; Liotta, D.; Snyder, J. Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system. J. Med. Chem. 2006, 49(11), 3153-8.

186. Dougherty, A.; McDonald, F.; Liotta, D.; Moody, S.;  Pallas, D.; Pack, C.; Merrill, A. Synthesis of 1-Deoxysphingsine Derivatives with Conformationally Restricted Pyrrolidinediol Head Groups. Org. Lett. 2006, 8(4), 649-52.

185. Doyle, J.; Prussia, A.; White, L.; Liotta, D.; Snyder, J.; Compans, R.; Plemper, R. Two Domains that Control Prefusion Stability and Transport Competence of the Measles Virus Fusion Protein. J. Virol. 2006, 80(3), 1524-36.

184.  Wiseman, J.; McDonald, F.; Liotta, D. 1-Deoxy-5-hydroxysphingolipids as New Anticancer Principles: An Efficient Procedure for Stereoselective Syntheses of 2-Amino-3,5-diols. Org. Lett. 2005, 7(15), 3155-3157.

183. Plemper, R.; Doyle, J.; Sun, A.; Prussia, A.; Cheng, L.; Rota, P.; Liotta, D.; Snyder, J.; Compans, R. Design of a Small Molecule Entry Inhibitor with Activity Against Primary Measles Virus Strains. Antimicrob. Agents Chemother. 2005, 49, 3755-3761.

182. Adams, B.; Cai, J.; Armstrong, J.; Herold, M.; Lu, Y.; Sun, A.; Snyder, J.; Liotta, D.; Jones, D.; Shoji, M. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anti-Cancer Drugs 2005, 16(3), 263-275.

181. Hernandez-Santiago, B.; Chen, H.; Asif, G.; Mao, S.; Beltran, T.; Hurwitz, S.; Grier, J.; McClure, H.; Chu, C.; Liotta, D.; Schinazi, R. Pharmacology and Pharmacokinetics of the Antiviral Agent ß-D-2′,3′-Dideoxy-3′-Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys. Antimicrob. Agents Chemother. 2005, 49 (7), 2589-2597.

180. Adams, B.; Ferstl, E.; Davis, M.; Herold, M.; Kurtkaya, S.; Camalier, R.; Hollingshead, M.; Kaur, G.; Sausville, E.; Rickles, F.; Snyder, J.; Liotta, D.; Shoji, M. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. Bioorg. Med. Chem. 2004, 12(14), 3871-3883.

179. Ambhaikar, N.; Liotta, D.; Herold, M. A Uniquely Accessible Route to the Diastereoselective Synthesis of Azetine Derivatives, Heterocycles, 2004, 62, 217-222.

178. Plemper, R.; Erlandson, K.; Lakdawala, A.; Sun, A.; Prussia, A.; Boonsombat, J.; Aki-Sener, E.; Yalcin, I.; Yildiz, I.; Temiz-Arpaci, O.; Tekiner, B.; Liotta, D.; Snyder, J.; Compans, J. A Target Site for Template-base Design of Measles Virus Entry Inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 5628-5633.

177. Painter, G.; Almond, M.; Mao, S.; Liotta, D. Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase. Curr. Med. Chem. 2004, 4(10), 1035-1044.

176. Mao, S.; Bouygues, M.; Welch, C.; Biba, M.; Chilenski, J.; Schinazi, R.; Liotta, D. The Synthesis and Anti-HIV Activity of Enantiomerically Pure D-FDOC. Bioorg. Med. Chem. Lett. 2004, 14, 4991-4994.

175. Menaldino, D.; Bushnev, A.; Sun, A.; Liotta, D.; Symolon, H.; Desai, K.; Dillehay, D.; Peng, Q.; Wang, E.; Allegood, J.; Trotman-Pruett, S.; Sullards, M.; Merrill, A. Sphingoid bases and de novo ceramide synthesis: Enzymes involed, pharmacology and mechinisma of activation/regulation, Pharm. Res. 2003, 47 (5), 373-381.

174. Guindon, Y.; Ogilvie, W.;Bordeleau, J.; Cui, W.; Durkin, K.; Gorys, V.; Juteau, H.; Lemieux, R.; Liotta, D.; Simoneau, B.; Yoakim, C. Opening of Tartrate Acetals Using Dialkylboron Bromide. Evidence for Stereoselectivity Downstream from Ring Fission, J. Amer. Chem. Soc. 2003,125(2), 428-436.

173. Painter,G.; Rimsky, L.; Furman, P.; Liotta, D.; Schinazi, R.; Quinn, J. Preclinical and Clinical Development of the anti-HIV, anti-HBV Oxathiolane Nucleoside Analog Emtricitabine. Front. Vir. Hep.2003, 451-484.

172. Ambhaikar, N.; Snyder, J.; Liotta, D. Diastereoselective Addition of Chlorotitanium Enolate of N-Acyl Thiazolidinethione to O-Methyl Oximes: A Novel, Stereoselective Synthesis of α,β-Disubstituted β-Amino Carbonyl Compounds via Chiral Auxiliary Mediated Azetine Formation. J. Am. Chem. Soc. 2003, 125 (3), 3690-3691.

171. Merrill, A., Sullards, M.; Allegood, J.; Wang, E.; Linn, S.; Andras,L.; Liotta, D.; Hartl, M.; Humpf, H. Insights into the modulation of ceramide metabolism by naturally occurring and synthetic sphingolipid analogs as monitored by electrospray tandem mass spectrometry, “Ceramide Signaling” (A. H.Futerman, ed., Landes Bioscience Pub.), ISBN: 0-306-47442-5, 2002.

170. Lakdawala, A.; Morgan, D.; Liotta, D.; Lynn, D.; Snyder, J. Dynamics and Fluidity of Amyloid: A Model of Fibrous Protein Aggregates, J. Am. Chem. Soc2002, 124 (51),15150-15151.

169. Morgan, D.; Lynn, D.; Lakdawala, A.; Liotta, D.; Snyder, J. Amyloid structure: models and theoretical considerations in fibrous aggregates. J. Chin. Chem. Soc. (Taipei, Taiwan) 2002, 49 (4), 459-466.

168. Ferstl, E.; Venkatesan, H.; Ambhaikar, N.; Snyder, J.; Liotta, D. Thiazolidine-2-thione directed diastereoselective addition of chlorotitanium enolates to aldimines. Synthesis 2002, (14), 2075-2083.

167. Painter, G.; Anderson, K.; Bouygues, M.; Joubert, M.; Liotta, D.Virally Encoded Polymerases as Targets for Chemotherapy: Application to HIV and HBV. Curr. Med. Chem.: Anti-Infective Agents 2002, 1 (2), 99-117.

166. Schinazi, R.; Mellors, J.; Bazmil, H.; Diamond, S.; Garber, S.; Gallagher, K.; Geleziunas, R.; Klabe, R.; Pierce, M.; Rayner, M.; Wu, J.; Zhang, H.; Hammond, J.; Bacheler, L.; Manion, D.; Otto, M.; Stuyver, L.; Trainor, G.; Liotta, D.; Erikson-Viitanen, S. DPC 817: a Cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants. Antimicrob. Agents Chemother. 2002, 46 (5), 1394-1401.

165. Desai, K.; Sullards, M.; Allegood, J.; Schmelz, E.; Hartl, M.; Humpf, H.; Liotta, D.; Peng, Q.; Merrill, A. Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis(Apoptosis induced by sphingoid bases). Biochem. Biophys. Acta special issue  2002, 1585 (2-3), 188-192.

164.  Nicolaou, K.; Namato, K.; Ritzen, A.; Ulven, T.; Shoji, M.; Li, J.; D’Amico, G.; Liotta, D.; Altmann, K.; Giannakakou, P. Chemical Synthesis and Biological Evaluation of cis- and trans- 12, 13-Cyclopropyl and 12,13-Cyclobutyl Epothilones and Related Pyridine Side Chain Analogues. J. Am. Chem. Soc. 2001, 123(38), 9313-9323.

163. Schinazi, R.; Hurwitz, S.; Liberman, I.; Juodawlkis, A.; Shi, J.; Liotta, D.; Coderre, J.; Olson, J. Preclinical Development of β-D-5-o-Carboranyl-2’-Deoxyuridine (D-CDU) for the Treatment of Malignant Brain Tumors. Frontiers in Neutron Capture Therapy (Hawthorne et al.,Ed.) 2001, 2, 1121-1124.

162.  Lakdawala, A.;  Wang, M.; Nevins, N.; Liotta, D.; Roszak, D.; Lozynski, M.; Snyder, J. Calculated Conformer Energies for Organic Molecules with Multiple Polar Functionalities are Method Dependent: Taxol (Case Study). BMC Chemical Biology 2001, 1:2 .

161. Hill, C.; Judd, D.; Nettles,J.; Nevins, N.; Schinazi, R.; Snyder, J.; Liotta, D.; Tang, J. Polyoxometalate HIV-1 Protease Inhibitors. Modeling Polyoxometalate-Enzyme Interactions. J. Am. Chem. Soc2001, 123, 886-897.

160. Venkatesan, H.; Davis, M.; Snyder, J.; Liotta, D. Total Synthesis of SR 121463 A, a Highly Potent and Selective Vasopressin V2 Receptor Antagonist. J. Org. Chem. 2001, 66, (11), 3653-3661.

159. Wang, M.; Cornett,B.; Nettles, J.; Liotta, D.; Snyder, J. The Oxetane Ring in Taxol. J. Org. Chem200065, 1059-1068.

158. Schinazi, R.; Hurwitz, S.; Liberman, I.; Juodawlkis, A.; Tharnish, P.; Shi, J.; Liotta, D.; Coderre, J.; Olson, J. Treatment of Isografted 9L Rat Brain Tumors with β-5-ο-Carboranyl-2’-Deoxyuridinr Neutron Capture Therapy. Clin. Cancer Res. 2000, 6, 725-730.

157. Curfman, C.; Liotta, D. Synthesis of Sphingosine and Sphingoid Bases. Methods Enzymol.: Sphingolipid Metabolism and Cell Signaling, 2000, 311, 391-440. (Merrill, A.; Hannun, Y. Eds.).

156.  Bushnev, A.; Liotta, D. Practical Synthesis of N-palmitoylsphingomyelin and N-palmitoyldihydrosphingomyelin. Methods Enzymol.: Sphingolipid Metabolism and Cell Signaling (A. H. Merrill and Y. A. Hannun, Eds.), 2000, 311, 535-546.

155. Wang, M.; Xia, D.; Schestopol, M.; Kim, Y.; Hwang, D.; Jansen, J.; Botta, M.; Liotta, D.; Snyder, J. A Unified and Quantitative Receptor Model for the Microtubule Binding of Taxol and Epothilone. Org. Lett. 1999, 1, 43-46.

154. Schmelz, E.; Bushnev, A.; Dillehay, D.; Sullards, M.; Liotta, D.; Merrill, A. Ceramide β-D-glucuronide: Synthesis, digestion and suppression of early biomarkers of colon carcinogenesis. Cancer Res. 1999, 59, 5768-5772.

153. Warden, L.; Menaldino, D.; Wilson, T.; Liotta, D.; Smith, E.; Merrill, A. Identification of ammonium ion and 2,6-bis-(ω-aminobutyl)-3,5-diimino-piperazine as endogenous factors that account for the burst of sphingosine upon changing the medium of J774 cells in culture. J. Biol. Chem. 1999, 48, 33875-33880.

152. Ma, L.; Hurwutz, S.; Shi, J.; McAtee, J.; Liotta, D.; McClure, H.; Schinazi, R. Pharmacokinetics of the Antiviral Agent ß-D-2’,3’-Didehydro-2’,-3’-Dideoxy-5-Fluorocytidine in Rhesus Monkeys. Antimicrob. Agents Chemother. 1999, 43(2), 381-384.

151. Shi, J.; McAtee, J.; Schlueter-Wirtz, S.; Tharnish, P.; Juodawlkis, A.; Liotta, D.; Schinazi, R. Synthesis and Biological Evaluation of 2’,3’-Didehydro-2’,3’-dideoxy-5-fluorocytidine (D4FC) Analogs: Discovery of Carbocyclic Nucleoside Triphosphates with Potent Inhibitory Activity Against HIV-1 Reverse Transcriptase. J. Med. Chem. 1999, 42, 859-867.

150. Schinazi, R.; McAtee, J.; Liotta, D. A Completely Diastereoselective Electrophilic Fluorination of a Chiral, Non-carbohydrate Sugar Ring Precursor: Application to the Synthesis of Several Novel 2’-Fluoro Nucleosides. J. Org. Chem. 1998, 63, 2161-2167.

149. Birt, D.; Merrill, A.; Barnett, T.; Enkvetchakul, B.; Pour, P.; Liotta, D.; Geisler, V.; Menaldino, D.; Schwartzbauer, J. Inhibition of Skin Carcinomas but not Papillomas by Sphingosine, N- methylsphingosine, and N-acetyl Sphingosine. Nutr & Cancer, 1998, 31, 119-126.

148.  Humpf, H.; Schmelz, E.; Meredith, F.; Vesper, H.; Vales, T.; Menaldino, D.; Liotta, D.; Merrill, A. Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase: Formationof N-Palmitoyl-aminopentol (PAP1) Produces a Toxic Metabolite of Hydrolyzed Fumonisin (AP1). J. Biol. Chem1998, 30, 19060-19064.

147. Snyder, J.; Xia, X.; Schestopol, M.; Kim, Y.; Bray, D.; Cain, M.; Liotta, D.; Koehler, K.; Jansen, J. Minireceptors for Molecular Design, in “Rational Molecular Design in Drug Research,” (T. Liljefors, F.S.Jorgenson, and P. Krogsgaard-Larsen, Eds., Munksgaard, Copenhagen). 1998, 115-135.

146. Schinzai, R.; McMillan, A.; Lloyd, R.; Schuleter-Wirtz, S.; Liotta, D.; Chu, C. Molecular Properties of HIV-1 Resistant to (+) and (–)-Enantiomers and Racemates of Oxathlolane Cytosine Nucleosides and their Potential for the Treatment of HIV and HBV Infections. Antiviral Res1997, 34 (2).

145. Nikolova-Karakashian, M.; Morgan, E.; Alexander, C.; Liotta, D.; Merrill, A. Bimodal Regulation of Ceramidase by Interleukin-1b: Implications for the Regulation of Cytochrome P450 2C11 (CYP2C11). J. Biol. Chem1997, 272, 18718-18724.

144. X. Xia, J. Wang, M. W. Hager, N. Sisti and D. Liotta. Stereocontrolled Synthesis of β-2’-Deoxypyrimidime Nucleosides via Intramolecular Glycosylations. Tetrahedron Lett. 1997, 38, 1111-1112.

143. Schmelz, E.; Bushnev, A.; Dillehay, D.; Liotta, D.; Merrill, A. Suppression of Aberrant Colonic Crypt Foci by Synthetic Sphingomyelina with Either Saturated of Unsaturated Sphingoid Base Backbones. Nutr. & Cancer 1997, 28, 81-85.

142. Kikolova-Karakashian, M.; Vales, T.; Wang, E.; Menaldino, D.; Alexander, C.; Goh, J.; Merrill, A.; Liotta, D. Ceramide Synthase and Ceramidases in the Regulation of Sphingolipid Base Metabolism. Sphingolipidmediated Signal Transduction. Molecular Biology Intelligence Unit, (Hannun Y. A., Ed.) 1997, 159-172.

141. Goudgaon, N.; El-Kattan, Y.; Xia, X.; McAtee, J.; Soria, J.; Wey, S.; Liotta, D.; Schinazi, R. A General Synthetic Method of 5-Carboranyluracil Nucleosides with Potential Antiviral Activity and Use in Neutron Capture Therapy, Nucleosides and Nucleotides 1997, 16, 2133-2150.

140. Merrill, A.; Liotta, D.; Riley, R. Fumonisins: Fungal Toxins that Shed Light on Sphingolipid Function. Trends Cell Biol. 1996, 6, 218.

139. Alexander, C.; Liotta, D. A Diastereoselective Synthesis of (2S, 3R, 4S)-Amino-1-cyclohexyl-6-methylheptane-3,4-diol, the Abbott Aminodiol. Tetrahedron Lett. 1996, 12, 1961.

138. Captain, L.; Xia; Xiaoyang; Liotta, D. Remote Asymmetric Induction in Organocopper Conjugate Additions to 3-Ketoacrylates. Tetrahedron Lett. 1996, 37 (25), 4293.

137. Merrill, A.; Liotta, D.; Riley, R. Bioactive Properties of Sphingosine and Structurally Related Compounds. Handbook of Lipid Research, Lipid Second Messengers 1996, 8, 205.

136. Merrill, A.; Liotta, D.; Riley, R. Sphingolipid Analog Biomodulators in Foods Alter Sphingolipid Metabolism. Implications for Health and Disease. Proc. Nutri. Soc. Australia, 1996, 20, 124.

135. Merrill, Jr., A.; Liotta, D.; Riley, R. Sphingolipids as Regulators of Cellular Growth, Differentiation, and Behavior. Adv. Lipobiology, 1996, 1, 273.

134. Merrill, A.; Wang, E.; Vales, T.; Smith, E.; Schroeder, J.; Menaldino, D.; Alexander, C.; Crane, H.; Xia, J.; Liotta, D.; Meredith, R.; Riley, R. Fumonisin Toxicity and Sphingolipid Biosynthesis. Proceedings of the ACS Symposium on Fumonisins in Food (April 2-7, 1995, Anaheim, CA), Adv. Exp. Med. Biol. 1996, 392, 297.

133. Liotta, D.; Jones, D. Origins of the Enantioselectivity Observed in Oxazaborolidine-Catalyzed Reductions of Ketones. Adv. Mol. Modeling 1995, 3, 1-19.

132. Wilson, L.; Hager, M.; Liotta, D. Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleosides Bases with Furanoside Sugars. Synthesis, 1995, 1465.

131. Jones, D.; Liotta, D. Episulfonium Ions May Not Be The Stereodeterminants In Glycosylations of 2-Thioalkyl Pyranosides. Adv. Mol. Modeling 1995, 3, 67-98.

130. Choi, W.; Churchill, H.; Lynch, J.; Volante, R.; Reider, P.; Shinkai, I.; Jones, D.; Liotta, D. An Unusual Stereoselective Decarboxylation: A Key Reaction in the Synthesis of an Important Intermediate for Carbapenem Antibiotics. J. Org. Chem1995, 60, 8367.

129. Xie, H.; Voronkov, M.; Liotta, D.; Korba, B.; Schinazi, R.; Richman, D.; Hostetler, K. Phosphatidyl-2′,3′-Thiacytidine: Synthesis and Antiviral Activity, in Hepatitis B and HIV-1 Infected Cells. Antiviral Res. 1995, 28, 113.

128. Wilson, L.; Hager, M.; El-Kattan, Y.; Liotta, D. Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleoside Bases With Furanoside Sugars. Synthesis 1995, 12, 1465-79.

127. Hoekstra, W.; Bonner, M.; Andrade-Gordon, P.; Evangelisto, M.; Keane, P.; Press, J.; Tomko, K.; Fan, F.; Kloczewiak, M.; Mayo, K.; Durkin, K.; Liotta, D. Design and Evaluation of Non-peptide Fibrinogen Gamma Chain Based GPIIB/IIIA Antagonists. J. Med.Chem1995, 38, 1582.

126. Chao, R.; Bielawska, A.; Pushkareva, M.; Crane, H.; Lagu, B.; Merrill, A.; Liotta, D.; Hannun, Y. Stereoselectivity of Induction of Rb Dephsophorylation by D-erythro-sphingosine Implicated Rb in Growth Suppression by Sphingosine. Biochem1995, 34, 1885.

125. V.Dirsch, J. Frederico, N. Zhao, G. Cai, Y. Chen, S. Vunnam, J. Odingo, H. Pu, K. Nakanishi, N. Berova, D. Liotta, A. Bielawska and Y. Hannun. A Two-Step Chemical and Circular Dichroic Method for Assigning the Absolute Configurations of Sphingosines. Tetrahedron Lett1995, 36, 4959.

124. Schroeder, J.; Crane, H.; Xia, J.; Merrill, A.; Liotta, D. Disruption of Sphingolipid Metabolism and Stimulation of DNA Synthesis by Fumonisin B1. A Molecular Mechanism for Carcinogenes Associated with Fursarium moniliforme. J. Biol. Chem., 1994, 269, 3475.

123. Lagu, B.; Liotta, D. Diastereoselective Synthesis of the Key Lactone Intermediate for the Preparation of Hydroxyethylene Dipeptide Isosteres. Tetrahedron Lett. 1994, 35(4), 547-50.

122.  Goh, J.; Lagu, B.; Wurster, J.; Liotta, D. Aldol Reactions of a-(N,N-Dibenzylamino) Ethyl Ketones. Tetrahedron Lett. 1994, 35(33), 6029-32.

121.  Jones, D.; Liotta, D.; Choi, W.; Volante, R.; Reider, P.; Shinkai, I.; Churchill, H.; Lynch, J. A Facially-Selective Protonation Controls the Stereochemistry of a Key Intermediate in the Synthesis of 1b-Methylcarbapenems. J. Org. Chem1994, 59(14), 3749-51.

120. Jarugula, V.; Schinazi, R.; Fulcrand, G.; El Kattan, Y.; Boudinot, F.; Liotta, D. Pharmacokinetics of 5-Carboranyl-2’-Deoxyuridine in Rats. J. Pharm. Sci1994, 83(12), 1697-9.

119. Schinazi, R.; Gosselin, G.; Faraj, A.; Korba, B.; Liotta, D.; Chu, C.; Mathe, C.; Imbach, J.; Sommadossi, J. Pure Nucleoside Enantiomers of b-2′,3′-Dideoxycytidine Analogues are Selective Inhibitors of Hepatitis B Virus and Human Immunodeficiency Virus in Vitro. Antimicrob. Agents Chemother. 1994, 38(9), 2172-4.

118. Hoekstra, W.; Press, J.; Bonner, M.; Andrade-Gordon, P.; Keane, P.; Durkin, K.; Liotta, D.; Mayo, K. Adamantane and Nipecotic Acid Derivatives as Novel b-Turn Mimics. Bio. Med. Chem. Lett. 1994, 4(11), 1361-4.

117. Schinazi, R.; Goudgaon, N.; Fulcrand, G.; El-Kattan, Y.; Lesnikowski, Z.; Moravek, J.; Liotta, D. Cellular Pharmacology and Biological Activity of 5-Carboranyl-2’-Deoxyuridine. Intl. J. Radiation Oncol. Int. J. Radiation Oncology Biol. Phys1994, 28(5), 1113-20.

116. Abobo, C.; Ni, L.; Schinazi, R.; Liotta, D.; Boudinot, F. Pharmacokinetics of 2′,3′-Dideoxy-5-fluoro-3′-thiacytidine in Rats. J. Pharm. Sci. 1994, 83(1), 96-9.

115. Guindon, Y.; Yoakim, C.; Gorys, V.; Ogilvie, W.; Delorme, D.; Renaud, J.; Robinson, G.; Lavallee, J.; Slassi, A.; Jung, G.; Rancourt, J.; Durkin, K.; Liotta, D. Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin. J. Org. Chem1994, 59(5), 1166-78.

114. Lagu, B.; Liotta, D. Surprisingly High Diastereoselection in the Aldol Reactions of Sodium Enolates of a-Amino Methyl Ketones. Tetrahedron Lett1994, 35(26), 4485-8.

113. El-Kattan, Y.; Goudgaon, N.; Fulcrand, G.; Liotta, D.; Schinazi, R. Synthesis of 5-Carboranyluracil and its Glycosylation with Normal and Modified Carbohydrates. Current Topics in the Chemistry of Boron (Royal Society of Chemistry), 1994, 181-4.

112. Bielawska, A.; Crane, H.; Liotta, D.; Obied, L.; Hannun, Y. Selectivity of Ceramide-Mediated Biology: Lack of Activity of Erthro-dihydroceramide. J. Biol. Chem. 1993, 268(35), 26226-32.

111. M. Y. Pushkareva, A. Bielawska, D. Menaldino and Y. Hannun. Regulation of Sphingosine-Activated Protein Kinases: Specificity of Activation by Sphingoid Bases and Inhibition by Free Fatty Acids. Biochem. J. 1993, 294 (pt3), 699-703.

110. Sperka, J.; Liotta, D. Onium Ions Are Not On The Reaction Coordinate In The Formation Of Heterocycles Via Electrophileinduced Alkenol Cyclizations. Heterocycles, 1993, 35(2), 701-6.

109. Mathez, D.; Schinazi, R.; Liotta, D.; Leibowitch, J. Infectious Amplification of Wild Type Human Immunodeficiency Virus from Patients’ Lymphocytes and their Modulation by Reverse Transcriptase Inhibitors In Vitro. Antimicrob. Agents Chemother1993, 37(10), 2206-11.

108. Wang, J.; Wurster, J.; Wilson, L.; Liotta, D. Stereocontrolled Glycosylations Via Additions of Sulfur Electrophiles to Glycals. Tetrahedron Lett1993, 34(31), 4881-4.

107. Jones, D; Liotta, D. Episulfonium Ions May Not Be The Stereodeterminants In Glycosylations of 2-Thioalkyl Pyranosides. Tetrahedron Lett. 1993, 34(45), 7209-12.

106. Lagu, B.; Crane, H.; Liotta, D. Highly Diastereoselective Aldol Reactions of Chiral Methyl Ketones. J. Org. Chem1993, 58(16), 4191-3.

105. Wilson, J.; Martin, J.; Borrota-Esoda, K.; Hopkins, S.; Painter, G.; Furman, P. The 5′-Triphosphates of the (-)- and (+)-Enantiomers of Cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3-Oxathioan-5-yl]Cytosine Equally Inhibit Human Immunodeficiency Virus Type-1 Reverse Transcriptase. Antimicrob. Agents Chemother. 1993, 37(8), 1720-2.

104. Schinazi, R.; Lloyd, R.; Nguyen, M.; Cannon, D.; Ilksoy, N.; Chu, C.; Liotta, D.; Bazmi, H.; Mellors, J. Characterization of Human Immunodeficiency Viruses Resistant to Oxathiolane-Cytosine Nucleosides. Antimicrob. Agents Chemother1993, 37(4), 875-81.

103. Schinazi, R.; Goudgaon, N.; Soria, J.; Liotta, D. Synthesis, Antiviral Activity, Cytotoxicity and Cellular Pharmacology of 5-Carboranyl-Pyrimidine Nucleosides. Advances in Neutron Capture Therapy, 1993, 285-8.

102. Van Roey, P.; Pangborn, W.; Schinazi, R.; Painter, G.; Liotta, D. Absolute Configuration of the Antiviral Agent (-)-Cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3-Oxathioan-5-yl]Cytosine. Antiviral Chem. Chemother1993, 4(6), 369-75.

101. Shewach, D.; Liotta, D.; Schinazi, R. Affinity of the Antiviral Enantiomers of Oxathioane Cytosine Nucleosides for Human 2′-Deoxycytidine Kinase. Biochem. Pharmacol. 1993, 45(7), 1540-3.

100.Frick, L.; Furman, P.; Liotta, D.; Painter, G.; Firfine, E.; Nelson, D. Pharmacokinetics, Oral Bioavailability and Metabolic Disposition in Rats of 2′-Deoxy-3′-thia-5-fluorocytidine, a Nucleoside Analog Active Against HIV and HBV. Antimicrob. Agents Chemother1993, 37(11), 2285-92.

99. Wilson, L.; Choi, W.; Spurling, T.; Liotta, D.; Schinazi, R.; Cannon, D.; Painter, G.; St. Clair, M.; Furman, P. The Synthesis and Anti-HIV Activity of Pyrimidine Dioxanyl Nucleoside Analogues. Bioorg. Med. Chem. Lett1993, 3(2), 169-74.

98. Choi, W.; Yeola, S.; Liotta, D.; Schinazi, R.; Painter, G.; St. Clair, M.; Furman, P. The Synthesis, Anti-HIV and Anti-HBV Activity of Pyrimidine Oxathiolane Nucleoside Analogues. Bioorg. Med. Chem. Lett. 1993, 3(4), 693-6.

97.  Jones, D.; Liotta, D.; Shinkai, I.; Mathre, D. Origins of the Enantioselectivity Observed in Oxazaborolidine-Catalyzed Reductions of Ketones. J. Org. Chem1993, 58(4), 799-801.

96. Hager, M.; Liotta, D. An Efficient Synthesis of 3′-Fluoro-3′-deoxythymidine (FLT). Tetrahedron Lett. 1992, 33(47), 7083-6.

95. Wurster, J.; Wilson, L.; Morin, G.; Liotta, D. Suppression of Racemization During the Diastereoselective C-3 Functionalization of 5-Hydroxymethyl-2-(5H)-furanones. Tetrahedron Lett. 1992, 33(39), 5689-92.

94. Chang, C.; Doong, S.; Zhou, J.; Beach, J.; Jeong, L.; Chu, C.; Liotta, D.; Schinazi, R.; Chang, Y. Deoxycytidine deaminase-resistant Stereoisomer is the Active Form of (-)-2′,3′-dideoxy-3′-thiacytidine in the Inhibition of Hepatitus B Replication. J. Biol. Chem1992, 267(20), 13938-42.

93. Schinazi, R.; McMillan, A.; Cannon, D.; Mathis, R.; Lloyd, R.; Peck, A.; Sommadossi, J.; St. Clair, M.;  Wilson, L.; Furman, P.; Choi, W.; Liotta, D. Selective Inhibition of Human Immunodeficiency Viruses by Racemates and Enantiomers of (Cis-5-fluoro-1-{2-hydroxymethyl)-1,3-oxythiolane-5-yl}cytosine. Antimicrob. Agents Chemother. 1992, 36(11), 2423-31.

92. Furman, P.; Davis, M.; Liotta, D.; Paff, M.; Frick, L.; Nelson, D.; Dornsife, R.; Wurster, J.; Wilson, L.; Tuttle, J.; Condrey, L.; Averett, D.; Schinazi, R.; Painter, G. The Anti-Hepatitis B Virus Activity, Cytotoxicity and Anabolic Profile of the (-) and (+) Enantiomers of Cis-5-fluoro-1-{2-hydroxymethyl)-1,3-oxythiolane-5-yl}cytosine (FTC). Antimicrob. Agents Chemother1992, 36 (12), 2686-92.

91. Schinazi, R.; Boudinot, F.; Ibrahim, S.; Manning, C.; McClure, H.; Liotta, D. Pharmacokinetics and Metabolism of Racemic 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine in Rhesus Monkeys. Antimicrob. Agents Chemother1992, 36(11), 2432-8.

90. Hoong, L.; Strange, L.; Liotta, D.; Koszalka, G.; Burns, C.; Schinazi, R. Enzyme-Mediated Enantioselective Preparation of Pure Enantiomers of the Antiviral Agent FTC and Related Compounds. J. Org. Chem. 1992, 57(21), 5563-5.

89. Durkin, K.; Liotta, D.; Rancourt, J.; Lavallée, J.; Boisvert, L.; Guindon, Y. Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. A Study of Transition States Using Semi-Empirical Calculations. J. Am. Chem. Soc. 1992, 114(12), 4912-14.

88. Wilson, L.; Liotta, D. Diastereoselective Sulfenylation Reactions Employing N -Thiophenyllactams Under Non-Basic Conditions. J. Org. Chem1992, 57(7), 1948-50.

87. Enkvetchakul, B.; Barnett, T.; Liotta, D.; Geisler, V.; Menaldino, D.; Merrill, A.; Birt, D. Influences of Sphingosine on Two-Stage Skin Tumorigenesis IN SENCAR Mice. Cancer Lett1992, 62(1), 35-42.

86. Schinazi, R.; Chu, C.; Peck, A.; McMillan, A.; Mathis, A.; Cannon, D.; Jeong, L.; Beach, J.; Choi, W.; Yeola, S.; Liotta, D. Activity of Four Optical Isomers of 2′,3′-Dideoxy-3′-Thiacytidine (BCH-189) Aganist HIV-1 in Human Lymphocytes. Antimicrob. Agents Chemother. 1992, 36(3), 672-6.

85. Swiss, K.; Hinkley, W.; Maryanoff, C.; Liotta, D. Complementary Facial Selectivity in Conjugate Additions to g-Hydroxyenones. Synthesis, 1992, (1-2), 127-31.

84. Doong, S.; Tsai, C.; Schinazi, R.; Liotta, D.; Cheng, Y. Inhibition of the Replication of Hepatitis B Virus In Vitro by 2′,3′-Dideoxy-3′-thiacytidine and Related Analogues. Proc. Natl. Acad. Sci. U.S.A1991, 88(19), 8495-9.

83. Choi, W.; Wilson, L.; Yeola, S.; Liotta, D.; Schinazi, R. In Situ Complexation Directs The Stereochemistry of N-Glycosylation in the Synthesis of Thialanyl and Dioxolanyl Nucleoside Analogues. J. Am. Chem. Soc1991, 113(24), 9377-9.

82. Swiss, K.; Choi, W.; Liotta, D.; Maryanoff, C.; Abdel-Magid, A. Use of Magnesium Cation in Aldol Additions – A Convenient Method for Achieving Anti-Aldol Selectivity. J. Org. Chem.1991, 56(21), 5978-80.

81. Merrill, A.; Liotta, D. Lipids as Hormones and Second Messengers. Current Opinions in Structural Biology 1991, 1(4), 516-21.

80. Hager, M.; Liotta, D. Cyclization Protocols for Controlling the Glycosidic Stereochemistry of Nucleosides. Application to the Synthesis of the Antiviral Agent, 3′-a-Azidothymidine (AZT). J. Am. Chem. Soc. 1991, 113(13), 5117.

79. Goldkorn, T.; Dressler, K.; Muindi, J.; Radin, N.; Mendelsohn, J.; Menaldino, D.; Liotta, D.; Kolesnick, R. Ceramide Stimulates Epidermal Growth Factor Receptor Phosphorylation in A431 Human Epidermoid Carcinoma Cells: Evidence that Ceramide Mediates Sphingosine Action. J. Biol. Chem1991, 266(24), 16092-7.

78. Liotta, D.; Swiss, K. Addition Reactions with Formation of Carbon-Sulfur or Carbon Selenium Bonds. Comprehensive Organic Chemistry (B. M. Trost, I. Fleming, Ed., S. V. Ley, Vol. Ed.) Pergamon Press, 1991, 7, 515 – 526.

77. Stevens, V.; Nimkar, S.; Jamison, W.; Liotta, D.; Merrill, A. Characteristics of the Growth Inhibition and Cytotoxicity of Long-chain (Sphingoid) Bases for Chinese Hamster Ovary Cells: Evidence for an Involvement of Protein Kinase C. Biochim. Biophys. Acta 1990, 1051(1), 37-45.

76. Liebeskind, L.; Chidambaram, R.; Nimkar, S.; Liotta, D. A Synthesis of the Abietane Diterpenoid Quinone Royleanone via Maleoylcobalt Technology. Tetrahedron Lett1990, 31(26), 3723-6.

75. Durkin, K.; Liotta, D. Solvation Controlled Diastereofacial Selectivity in Alkylations of Bicyclic Lactam Enolates. J. Am. Chem. Soc1990, 112(22), 8162-3.

74. Swiss, K.; Liotta, D.; Maryanoff, C. Mechanistic Aspects of Ligand Assited Nucleophilic Addition Reactions. J. Am. Chem. Soc., 1990, 112(25), 9393-4.

73. Durkin, K.; Sherrod, M.; Liotta, D. Empirical Derivation of Molecular Mechanics Parameter Sets: Application to b-Lactams. Advances in Molecular Modeling, 1990, JAI Press, 2, 93-133.

72. Wilson, L.; Liotta, D. A General Method for Controlling Glycosylation Stereochemistry in the Synthesis of 2′-Deoxyribose Nucleosides. Tetrahedron Lett1990, 31(13), 1815-18.

71. Swiss, K.; Choi, W.; Mohan, J.; Barnum, C.; Saindane, M.; Zima, G.; Liotta, D. Reactions Involving Selenium Metal As An Electrophile. Scope and Limitations of the Enolate-Selenolate Transformation. Heteroatom Chem. 1990, 1(2), 141-9.

70. Greenberg, P.; Merrill, A.; Grabowski, G.; Liotta, D. Human acid b-Glucosidase: Use of Sphingosyl and N-Alkyl-Glucosylamine Inhibitors to Investigate the Properties of the Active Site. Biochim. Biophys. Acta 1990, 1039(1), 12-20.

69. Durkin, K.; Sherrod, M.; Liotta, D. A New Model Parameter Set for β-Lactams. J. Org. Chem1989, 54(25), 5839-41.

68. Slife, C.; Wang, E.; Hunter, R.; Wang, S.; Burgess, C.; Liotta, D.; Merrill, A. Free Sphingosine Formation from Endogenous Substrates by a Liver Plasma Membrane System with a Divalent Cation Dependence and a Neutral pH Optimum. J. Biol. Chem. 1989, 264(18), 10371-7.

67. Rodriguez-Paris, J.; Shoji, M.; Yeola, S.; Liotta, D.; Vogler, W.; Kuo, J. Fluorimetric Studies of Protein Kinase C Interactions with Phospholipids. Biochem. Biophys. Res.Commun1989, 159(2), 495-500.

66. McCormick, M.; Monahan, R.; Soria, J.; Goldsmith, D.; Liotta, D. Effects of Substitution on Intramolecular Alkoxypalladation Carbonylation Reactions. J. Org. Chem. 1989, 54(19), 4485-7.

65. Merrill Jr., A.; Nimkar, S.; Menaldino, D.; Hannun, Y.; Loomis, C.; Bell, R.; Tyagi, S.; Lambeth, J.; Stevens, V.; Hunter, R.; Liotta, D. Structural Requirements for Long-Chain (Sphingoid) Bases as Inhibitors of Protein Kinase C in vitro and Cellular Effects of These Compounds. Biochemistry 1989, 28(8), 3138-45.

64. Wilson, E.; Wang, E.; Mullins, R.; Uhlinger, D.; Liotta, D.; Lambeth, J.; Merrill, A. Modulation of the Free Sphingosine Levels in Human Neutrophils by Phorbol Esters and Other Factors. J. Biol. Chem. 1988, 263(19), 9304-9.

63. Hoekstra, W.; Zima, G.; Solomon, M.; Liotta, D. The Case Favoring Direct C-Alkylation of Heteroatom-Substituted Enolates. J. Org. Chem1988, 53(21), 5058-62.

62. Solomon, M.; Jamison, W.; McCormick, M.; Liotta, D.; Cherry, D.; Mills, J.; Shah, R.; Rogers, J.; Maryanoff, C.; Paragamian, V. Ligand Assisted Nucleophilic Additions. Control of Site and Face Attack of Nucleophiles on 4-Oxido Enones. J. Am. Chem. Soc1988, 110(11), 3702-4.

61. Nimkar, S.; Menaldino, D.; Jamison, W.; Merrill, A.; Liotta, D. A Stereoselective Synthesis of Sphingosine, A Protein Kinase C Inhibitor. Tetrahedron Lett. 1988, 29(25), 3037-40.

60. Dunams, T.; Hoekstra, W.; Pentaleri, M.; Liotta, D. Molecular Aggregation and Its Applicability to Synthesis. The Diels-Alder Reaction. Tetrahedron Lett1988, 29(31), 3745-8.

59. Liotta, D.; Saindane, M.; Waykole, L.; Grossman, J.; Stephens, J. Trajectories of Proton Transfer Reactions. Experimental Determination of the Magnitude of Primary Deuterium Isotope Effects for Proton-transfers Occurring at Acute Angles. J. Am. Chem. Soc. 1988, 110(8), 2667-8.

58. Merrill, A.; Wang, E.; Mullins, R.; Jamison, W.; Nimkar, S.; Liotta, D. Quantitation of Free Sphingosine in Liver by High-Performance Liquid Chromatography. Anal. Biochem. 1988, 171(2), 373-81.

57. Kaufman, M.; Jamison, W.; Liotta, D. Coal Liquefaction In A Flourocarbon Medium. II. Kinetics of the 1,2,3,4-Tetrahydroquinoline Reaction. Fuel 1987, 66, 1621.

56. Liotta, D.; Brown, D.; Hoekstra, W.; Monahan, R. Pyridinium Dichromate-Induced 1,3-Oxidative Rearrangements of Enynols. Tetrahedron Lett. 1987, 28 (10), 1069-72.

55. Maryanoff, B.; Nortey, S.; Inners, R.; Campbell, S.; A. B. Reitz and D.C. Liotta. Synthesis of C-Arabinofuranosides. Phosphonate and Carboxylate Isosteres of b-D-Arabinose-1,5-Diphosphate. Carbohydr. Res. 1987, 171, 259-78.

54.  Reitz, A.; Nortey, S.; Maryanoff, B.; Liotta, D.; Monahan, R. Stereoselectivity of Electrophile-Promoted Cyclizations of g-Hydroxyalkenes. An Investigation of Carbohydrate-Derived and Model Substrates. J. Org. Chem. 1987, 52(19), 4191-4204.

53. Liotta, D.; Ott, W. Triene Cyclizations. Total Synthesis of Pallescensin A. Synth. Commun., 1987, 17(14), 1655-65.

52. Nucleophilic Selenium in “Organoselenium Chemistry” (Wiley-Interscience), D. Liotta, Ed., 1987, 207-242. Liotta, D.; Monahan, R.; Waykole, L.; Brown, D.

51. Liotta, D.; Saindane, M.; Monahan, R.; Brothers, D.; Fivush, A. Rearrangement of α-Phenylselenenyl Ketones. Synth. Commun1986, 16 (12), 1461-8.

50. Liotta, D.; Saindane, M.; Brothers, D. Based-Induced Rearrangements of a-Phenylselenenyl Ketones. J. Org. Chem1982, 47 (8), 1598-600.

49. Liotta, D.; Monahan, R. Selenium in Organic Synthesis. Science 1986, 231 (4736), 356-61.

48. Kaufman, M.; Jamison, W.; Liotta, D. Coal Liquefaction in a Fluorocarbon. 1. Nitrogen Compounds as Hydrogen Transfer Agents. Fuel 1986, 65 (1), 148-50.

47. Fraser-Reid, B.; Grossman, J.; Underwood, R.; Osterhout, M.; Liotta, D. Some Observations on the Relative Reactivities of a-Enones of Oxanes and Cyclohexanes. J. Org. Chem1986, 51(11), 2152-5.

46. Liotta, D; Saindane, M.; Barnum, C.; Zima, G. Synthetic Applications of 2-Phenylselenenylenones. 3. An Overview. Tetrahedron 1985, 41(21), 4881-9.

45. Goldsmith, D.; Liotta, D.; Waykole, L.; Hoekstra, W.; Volmer, M. Preparation and Reactivity of α-phenylselenyl Ethers. Tetrahedron 1985, 41 (21), 4873-80.

44. Gupton, J.; DeCrexcenzo, G.; Colon, C.; Baran, D.; Dukesherer, D.; Novick, S.; Liotta, D.; Idoux, P. Regioselective fluoroalkoxylation and polyfluoroalkoxylation of aromatic and heteroaromatic polyhalides. Can. J. Chem. 1985, 63 (11), 3037-42.

43. Bresciani-Pahor, N.; Calligaris, M.; Randaccio, L.; Marzilli, L.; Summers, M.; Toscano, P.; Grossman, J.; Liotta, D. The 2,2,2-Trifluoroethyl Ligand: A Structural “Reporter” Group for Carbanion Character of Alkyl Ligands in Organometallic Compounds. Organometallics 1985, 4(4), 630-6.

42. Liotta, D.; Saindane, M.; Sunay, U.; Jamison, W.; Phillips, P.; Grossman, J. Acetylide Additions to Enediones. Regioselectivity Based on Stereoelectronic Control. J. Org. Chem. 1985, 50 (17), 3241-3.

41. Liotta, D. New Organoselenium Methodology. Accounts Chem. Res., 1984, 17(1), 28-34.

40. Liotta, D. The Chemistry of 2-Phenylselenenylenones. Proceedings of the Fourth International Conference on the Organic Chemistry of Selenium and Tellurium 1983, 278-96.

39. Goldsmith, D.; Liotta, D.; Saindane, M.; Waykole, L.; Bowen, P. 3-Alkylfurans as Useful Synthetic Equivalents for Substituted D2-Butenolides. Tetrahedron Lett. 1983, 24(52), 5835-8.

38. Liotta, D.; Arbiser, J.; Short, J.; Saindane, M. A Simple, Inexpensive Procedure for the Large Scale Production of Alkyl Quinones. J. Org. Chem. 1983, 48 (17), 2932-33.

37. Liotta, D.; Saindane, M.; Waykole, L. New Probes for Electron Transfer Processes. Evidence Supporting the Single Electron Transfer Mechanism in Additions of Carbanions to Dienones. J. Am. Chem. Soc. 1983, 105 (9), 2922-3.

36. Liotta, D.; Saindane, M.; Ott, W. A Simple, Efficient Synthesis of 3-Substituted Furans. Tetrahedron Lett. 1983, 24 (24), 2473-6.

35. Menger, F.; Grossman, J.; Liotta, D. Transition State Pliability in N-to-N Proton Transfer. J. Org. Chem. 1983, 48 (6), 905-7.

34. Lehman, T.; Bursey, M.; Harvan, D.; Hass, J.; Liotta, D.; Waykole, L. Identity of Collisional Activation Spectra of Some Positive Ions Produced Both by Reversal of Negative Ions and by Decomposition of Positive Ions. Org. Mass. Spec. 1982, 17 (12), 607-11.

33. Liotta, D.; Sunay, U.; Ginsberg, S. Phosphonosilylations of Cyclic Enones. J. Org. Chem. 1982, 47(11), 2227-9.

32.  Liotta, D.; Saindane, M.; Brothers, D. Base-induced Rearrangements of a-Phenylselenenyl Ketones. J. Org. Chem. 1982, 47(8), 1598-600.

31. Liotta, D.; Zima, G.; Saindane, M. The Origins of Regio- and Stereoselectivity in Additions of Phenylselenenyl Chloride to Allylic Alcohols and the Applicability to These Additions to a Simple 1,3-Enone Transposition Sequence. J. Org. Chem. 1982, 47(7), 1258-67.

30. Baker, A.; Horozoglu, G.; Guang-Di, Y.; Liotta, D.; Zima, G.; Barnum, C.; Flannagan, N. The Photoelectron Spectra of Alkyl Aryl Selenides. Electronic and Steric Factors in the Observation of Rotamers. J. Org. Chem. 1981, 46(21), 4127-30.

29. Liotta, D.; Barnum, C.; Saindane, M. Synthetic Applications of 2-Phenylselenenylenones. 2. The Synthesis of Dihydrojasmone and cis-Jasmone. J. Org. Chem. 1981, 46 (21), 4301-4.

28. Liotta, D.; Saindane, M.; Barnum, C.; Ensley, H.; Balakrishan, P. Reactions Involving Selenium Metal as an Electrophile. 2. A General Procedure for the Preparation of Unsaturated b-Dicarbonyl Compounds. Tetrahedron Lett. 1981, 22 (32), 3043-6.

27. Liotta, D.; Saindane, M.; Barnum, C. Selective Reactions of Carbanions with p-Quinones. The Aggregate Model. J. Org. Chem. 1981, 46 (16), 3369-70.

26. Liotta, D.; Sunay, U.; Santiesteban, H.; Markewicz, W. Phenyl Selenide Anion. A Superior Reagent for SN2-Type Cleavages of Esters and Lactones. J. Org.Chem. 1981, 46 (13), 2605-10.

25. Liotta, D.; Barnum, C.; Puleo, R.; Zima, G.; Bayer, C.; Kezar, H. A Simple Method for the Efficient Synthesis of Unsaturated b-Dicarbonyl Compounds. J. Org. Chem. 1981, 46(14), 2920-3.

24. Liotta, D.; Saindane, M.; Barnum, C. Diels-Alder Reactions Involving Cross-Conjugated Dienones. Effects of Substitution on Reactivity. J. Am. Chem. Soc. 1981, 103(11), 3224-6.

23. Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet and X-ray Excitation. Anal. Chem. 1980, 52(5), 161R-174R.

22. Liotta, D.; Zima, G.; Barnum, C.; Saindane, M. Reactions Involving Selenium Metal as an Electrophile. The Enolate-Selenolate Transformation, Tetrahedron Lett. 1980, 21 (38), 3643-6.

21. Liotta, D.; Zima, G.; Barnum, C. Synthetic Applications of 2-Phenylselenenylenones. Selective Formation of Exocyclic or Endocyclic Enones from a Common Intermediate, J. Org. Chem. 1980, 45, 2736.

20. Liotta, D.; Zima, G. Synthetic Applications of Phenylselenenyl Chloride Additions. A Simple 1,3-Enone Transposition Sequence. J. Org. Chem. 1980, 45 (13), 2551-3.

19. Goldsmith, D.; Liotta, D.; Lee, C.; Zima, G. The Reactions of β,γ-Unsaturated Acids with Phenylselenenyl Chloride. Decarboxylative Elimination vs. Phenylselenolactonization. Tetrahedron Lett. 1979, 50, 4801-4.

18. Zima, G.; Liotta, D. A General Synthesis of 2-Phenylselenenylenones. The Reactions of Unsaturated Ketones with a Phenylselenenyl Chloride/Pyridine Complex. Synth. Commun. 1979, 9 (8), 697-703.

17. Liotta, D.; Paty, P.; Johnson, J.; Zima, G. Synthetic Applications of Phenyl(trimethylsilyl)selenide, Tetrahedron Lett. 1978, 51, 5091-4.

16. Liotta, D.; Zima, G. An Examination of the Synthetic Utility of Phenylselenenyl Chloride Additions to Olefins. Tetrahedron Lett. 1978, (50), 4977-80.

15. Baker, A.; Wong, D.; Lo, S.; Bloch, M.; Horozoglu, G.; Goldman, N.; Engel, R.; Liotta, D. The Reaction N-Aryl Nitrones with Dichloroketene: A New Synthesis of Isatins. Tetrahedron Lett1978, 215.

14. Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet and X-Ray Excitation. Anal. Chem. 1978, 50 (5), 328R-46R.

13. Liotta, D.; Markiewicz, W.; Santiesteban, H. The Generation of Uncomplexed Phenyl Selenide Anion and Its Applicability of SN2-Type Cleavages. Tetrahedron Lett1977, (50), 4365-8.

12. Liotta, D.; Markiewicz, W.; Santiesteban, H. Nucleophilic Ring Opening of Lactones via SN2-Type Reactions with Uncomplexed Phenyl Selenide Anion. Tetrahedron Lett. 1977, (50) 4369-72.

11. Paquette, L.; Liotta, D.; Liao, C.; Wallis, T.; Eickman, N.; Clardy, J.; Gleiter, R. Endoperoxidation of Conformationally Fixed Norcaradienes by Singlet Oxygen. Frontier Molecular Orbital Basis for the Operability of 1O2 Quenching by Hydrazides. J. Am. Chem. Soc., 1976, 98 (20), 6413-16.

10.  Paquette, L.; Liao, C.; Liotta, D.; Fristad, W. Reversal of Stereospecificity During Allylic Hydroperoxidation of D3-Norcarene and Bicyclo [4.2.0] Oct-3-ene Derivatives Arising from Structurally Enforced Quenching of Singlet Oxygen by the Hydrazide Functionality. J. Am Chem. Soc. 1976, 98 (20), 6412-14.

9. Paquette, L.; Liotta, D.; Baker, A. Frontier Molecular Orbital Basis for the Structurally Dependent Regiospecific Reactions of Singlet Oxygen with Polyolefins. Tetrahedron Lett. 1976, (31), 2681-4.

8. Baker, A.; Brisk, M.; Venanzi, T.; Kwon, Y.; Sadka, S. Spiroconjugation Involving Sulfur 3p Atomic Orbitals. Tetrahedron Lett. 1976, 17 (38), 3415-18.

7. Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet Excitation. Anal. Chem. 1976, 48, 281R-94R.

6. Liotta, D.; Engel, R. The Thermal Decomposition of Alkoxycarbonyl Thiocyanates and Isothiocyanates. Can. J. Chem. 1975, 53, 907-12.

5. Liotta, D.; Baker, A.; Goldman, N.; Engel, R. Reactions of N-Aryl Nitrogen Oxides. The Reactions of N-Aryl Nitrones with Oxalyl Chloride. J. Org. Chem. 1974, 39 (13).

4.  Liotta, D.; Baker, A.; Goldman, N.; Engel, R. Reactions of N-Aryl Nitrogen Oxides. 1. Selective Ortho-Chlorination in the Reaction of Aryl Nitrones and Amine Oxides with Thionyl Chloride or Phosgene. J. Org. Chem. 1974, 39(18).

3. Liotta, D.; Baker, A.; Goldman, N.; Weinstein, F.; Felsen, D.; Engel, R. The Reaction of N-Aryl Nitrones with Thionyl Chloride or Phosgene. J. Org. Chem. 1973, 39, 3445.

2. Engel, R.; Santo, T.; Liotta, D.; Freed, D. Enhanced Nucleophilic Displacement in Phosphinite Esters. Chem. Commun. 1970, 646a.

1. Engel, R.; Liotta, D. The Thermal Decomposition of Trialkyl Phosphorothioates. J. Chem. Soc. C, 1970, 523.