Emory Mental Health and Development has been part of the North American Prodrome Longitudinal Studies (NAPLS) consortium. The NAPLS sites collaborate on studies of the early indicators of risk for serious mental illness. Drawing on increased scientific understanding of brain development during adolescence and early adulthood, investigators hope to identify factors that contribute to mental illness in adolescence and young adulthood. For more information about the NAPLS project, check the following website; http://napls.commons.yale.edu .
Some Recent Publications
Goines, K. B., LoPilato, A. M., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Mathalon, D. H., McGlashan, T. H., Perkins, D. O., Tsuang, M. T., Woods, S. W., & Walker, E. F. (2019). Sleep problems and attenuated psychotic symptoms in youth at clinical high-risk for psychosis. Psychiatry Research, 282, 112492. https://doi.org/10.1016/j.psychres.2019.112492
Psychotropic Medication and Cortisol
Subramaniam, A., LoPilato, A., & Walker, E. F. (2019). Psychotropic medication effects on cortisol: Implications for research and mechanisms of drug action. Schizophrenia Research, 213, 6–14. https://doi.org/10.1016/j.schres.2019.06.023
Addington, J., Stowkowy, J., Liu, L., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Bearden, C. E., Mathalon, D. H., Santesteban-Echarri, O., & Woods, S. W. (2019). Clinical and functional characteristics of youth at clinical high-risk for psychosis who do not transition to psychosis. Psychological Medicine, 49(10), 1670–1677. https://doi.org/10.1017/S0033291718002258
Developmental mechanisms in the prodrome to psychosis
Walker, E. F., Trotman, H. D., Goulding, S. M., Holtzman, C. W., Ryan, A. T., McDonald, A., Shapiro, D. I., & Brasfield, J. L. (2013). Developmental mechanisms in the prodrome to psychosis. Development and Psychopathology, 25(4 Pt 2), 1585–1600. https://doi.org/10.1017/S0954579413000783
Cullen, A. E., Addington, J., Bearden, C. E., Stone, W. S., Seidman, L. J., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Mathalon, D. H., McGlashan, T. H., Perkins, D. O., Tsuang, M. T., Woods, S. W., & Walker, E. F. (2020). Stressor-Cortisol Concordance Among Individuals at Clinical High-Risk for Psychosis: Novel Findings from the NAPLS Cohort. Psychoneuroendocrinology, 115, 104649. https://doi.org/10.1016/j.psyneuen.2020.104649
Schizophrenia: A Neural-Diathesis Stress Model
Walker, E. F., & Diforio, D. (1997). Schizophrenia: A neural diathesis-stress model. Psychological Review, 104(4), 667–685. https://doi.org/10.1037/0033-295x.104.4.667
Longitudinal changes in cortisol secretion and conversion to psychosis in at-risk youth
Walker, Elaine F., Brennan, P. A., Esterberg, M., Brasfield, J., Pearce, B., & Compton, M. T. (2010). Longitudinal changes in cortisol secretion and conversion to psychosis in at-risk youth. Journal of Abnormal Psychology, 119(2), 401–408. https://doi.org/10.1037/a0018399
Advances in the Neurobiology of Stress and Psychosis
Mittal, V. A., & Walker, E. F. (2019). Advances in the neurobiology of stress and psychosis. Schizophrenia Research, 213, 1–5. https://doi.org/10.1016/j.schres.2019.08.030