I know that there is a very long and boring set of instructions for writing NIH grants, called the SF424: https://grants.nih.gov/grants/how-to-apply-application-guide.html This page is particularly helpful in listing what the review criteria are, and some tips about writing the proposal. https://grants.nih.gov/grants/how-to-apply-application-guide/format-and-write/write-your-application.htm
For example, under Writing Tip #3:
- Write a clear topic sentence for each paragraph with one main point or idea. This is key for readability.
- Make your points as direct as possible. Avoid jargon or excessive language.
- Write simple and clear sentences, keeping to about 20 words or less in each.
What points should you address?
I can’t find it in the current online version of the guidelines, but the prior PDF version of the SF424 has some very salient questions that you should make sure the various sections of your proposal address.
If you cannot easily find a single topic (first) sentence of a paragraph that is followed by evidence to address the point below, then you probably haven’t focused your writing enough to what the reviewers want to know. As a reviewer, I scan the document, read the first sentences of each paragraph to see if I can catch the answers to these questions before diving in.
And, as a rule, the first sentence of each paragraph should be coordinated so that they form the logical underpinnings of your research proposal, with the stuff in the paragraphs supplying the necessary evidence for each point. So one paragraph, one topic, and if I agree with your assertion, then I won’t read further into the paragraph in much detail, but if I disagree then I’ll be scrutinizing the data and literature that you present.
Here they are:
Specific Aims
State concisely the goals of the proposed research and summarize the expected outcome(s), including the impact that the results of the proposed research will exert on the research field(s) involved.
List succinctly the specific objectives of the research proposed, e.g., to test a stated hypothesis, create a novel design, solve a specific problem, challenge an existing paradigm or clinical practice, address a critical barrier to progress in the field, or develop new technology.
Significance
Explain the importance of the problem or critical barrier to progress in the field that the proposed project addresses.
Explain how the proposed project will improve scientific knowledge, technical capability, and/or clinical practice in one or more broad fields.
Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will be changed if the proposed aims are achieved
Innovation
Explain how the application challenges and seeks to shift current research or clinical practice paradigms.
Describe any novel theoretical concepts, approaches or methodologies, instrumentation or interventions to be developed or used, and any advantage over existing methodologies, instrumentation, or interventions.
Explain any refinements, improvements, or new applications of theoretical concepts, approaches
Approach
Describe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project. Unless addressed separately in the Resource Sharing Plan attachment below, include how the data will be collected, analyzed, and interpreted.
Discuss potential problems, alternative strategies, and benchmarks for success anticipated to achieve the aims. • _If the project is in the early stages of development, describe any strategy to establish feasibility, and address the management of any high risk aspects of the proposed work.