A list of radioactive drugs & PET ligands developed\/characterized by our group (drug targets in alphabetical order)<\/strong><\/span><\/p>\n\n\n\n D<\/em>-Amino acid oxidase (DAAO)<\/strong><\/span><\/p>\n \u00a0<\/p>\n\n\n\n \u03b1-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor with or without focusing GluA2 subunit (GluA2)<\/strong><\/span><\/p>\n \u00a0<\/p>\n\n\n\n Anaplastic lymphoma kinase – [11<\/sup>C\/18<\/sup>F]lorlatinib drug labeling <\/p>\n\n\n\n Autotaxin (ATX)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Cholesterol 24S-hydroxylase (CYP46A1) <\/p>\n\n\n\n <\/p>\n\n\n\n Fatty acid amide hydrolase (FAAH)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Glycogen synthase kinase 3 (GSK3) <\/p>\n\n\n\n Histamine H3 receptor (H3)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n L<\/em>-Type Amino Acid Transporter (LAT1)<\/strong><\/span><\/p>\n under review<\/p>\n\n\n\n L<\/em>-Type calcium channel<\/strong> <\/span><\/p>\n <\/p>\n\n\n\n Leucine-rich repeat kinase 2 (LRRK2)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Metabotropic glutamate receptor 2 (mGluR2)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Metabotropic glutamate receptor 7 (mGluR7)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Metal binder in the brain – copper (Cu) and Zinc (Zn) binder <\/strong><\/span><\/p>\n <\/p>\n\n\n\n N<\/em>-Methyl D<\/em>-aspartate (NMDA) receptor subtype 2B (NR2B or GluN2B) <\/p>\n\n\n\n Monoacylglycerol lipase (MAGL)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Muscarinic acetylcholine receptor subtype 4 (M4)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Orexin receptor 2 (OX2)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Phosphodiesterase 1 (PDE1)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Phosphodiesterase 4B (PDE4B)<\/strong><\/span><\/p>\n In progress<\/p>\n\n\n\n Phosphodiesterase 7 (PDE7)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Phosphodiesterase 10A (PDE10A)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Poly [ADP-ribose] polymerase 1 (PARP1)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Protein tyrosine kinase 7 (PTK-7) –<\/span> single-stranded DNA aptamer targeted PET ligand (18<\/sup>F-sgc8)<\/span><\/strong><\/p>\n <\/p>\n\n\n\n Retinoid X receptors (RXRs) – repurposing Bexarotene for Alzheimer’s treatment <\/p>\n\n\n\n RNA-dependent RNA polymerase (RdRp) – pharmacokinetics study of [18<\/sup>F]Favipiravir in the brain<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Single domain antibody fragments (VHHs) – click chemistry applications of anti class II MHC and anti CD11b targeted PET imaging<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Trace amine-associated receptor subtype 1 (TAAR1)<\/span> <\/p>\n\n\n\n Translocator protein (TSPO)<\/strong><\/span><\/p>\n <\/p>\n\n\n\n Transmembrane AMPAR regulatory protein (TARP) – gamma 8 subtype (TARP \u03b38) <\/p>\n\n\n\n Vasopressin receptor 1A (V1A)<\/span> <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" Overview page A list of radioactive drugs & PET ligands developed\/characterized by our group (drug targets in alphabetical order) D-Amino acid oxidase (DAAO) \u00a0 \u03b1-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor with or without focusing GluA2 subunit (GluA2) \u00a0 Anaplastic lymphoma kinase – [11C\/18F]lorlatinib drug labeling Autotaxin (ATX) Cholesterol 24S-hydroxylase (CYP46A1) Read More …<\/a><\/p>\n","protected":false},"author":8331,"featured_media":0,"parent":172,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1180","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/pages\/1180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/users\/8331"}],"replies":[{"embeddable":true,"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/comments?post=1180"}],"version-history":[{"count":161,"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/pages\/1180\/revisions"}],"predecessor-version":[{"id":2351,"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/pages\/1180\/revisions\/2351"}],"up":[{"embeddable":true,"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/pages\/172"}],"wp:attachment":[{"href":"https:\/\/scholarblogs.emory.edu\/radiochem\/wp-json\/wp\/v2\/media?parent=1180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/scholarblogs.emory.edu\/radiochem\/files\/2024\/08\/DAAOb.png\")
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