This site started in the summer of 2016 in an effort to precipitate thoughts and uncertainties regarding the scientific inquiry of the epidemiology of sepsis with a humble intention to improve the field in any way and explore general avenues for resource sharing in science.

Sepsis: The Third International Consensus defines sepsis as a “life-threatening organ dysfunction caused by a dysregulated host response to infection”.   Moreover, the Consensus clarifies that sepsis is not a “specific illness, but rather a syndrome encompassing a still-uncertain pathobiology.”  These statements succinctly and simultaneously encompass the breadth, levity and ambiguity surrounding this human adversary.

Epidemiology: According to the World Health Organization, epidemiology is “is the study of the distribution and determinants of health-related states or events (including disease), and the application of this study to the control of diseases and other health problems”.

Epidemiology + Sepsis: In the broadest (and by corollary, most vague) attempt at defining this conceptual marriage, the epidemiology of sepsis seeks to develop the knowledge of the population distribution of the prevalence and incidence of sepsis and its morbidity, mortality and socioeconomic costs across geopolitical boundaries, social strata, environmental exposures and groupings of pre-existing health conditions.  The global intent of this knowledge is to motivate and inform clinical practices and health policies  to develop and modify strategies aimed at reducing the public health burden of sepsis.  More specifically, the work is aimed at reducing the incidence of sepsis through identifying primary and secondary prevention strategies, reducing social disparities in sepsis by identifying the factors that mediate them across different social domains and reducing morbidity and morality from sepsis by identifying effective healthcare systems policies.  These goals remain optimistic despite the realization that the current starting point for this work in 2016 is that there is no currently accepted epidemiologic or surveillance definition for sepsis.

Specific Aims of this Site:

  • Present an open-access research portfolio of investigations into miscellaneous topics surrounding the epidemiology of sepsis.
  • Use public domain data, open source software and publically available code to encourage others to engage in, learn from, critique and build upon available resources for study in this area.
  • Serve as a Blog Post for review of recent research in this area.