Positive Allosteric Modulators that Treat Central Nervous System Disorders

Application Small molecules that selectively potentiate N-methyl-D-aspartate (NMDA) receptor subunits GluN2C/GluN2D for the treatment of neurological conditions. Key Benefits Selective potentiation of only NMDA receptor that contain GluN2C or GluN2D subunits will likely reduce adverse side effects. Selective potentiation of only NMDA receptor that contain GluN2C or GluN2D subunits may yield better pharmacological and pharmacokinetic properties versus global NMDA receptor antagonists. Read More

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