Natural product total synthesis | Medicinal chemical biology
We synthesize natural products with interesting antibacterial activity to identify their biological targets. Using synthetic chemistry, we build derivatives of these compounds to optimize their potency and then use microbiological techniques to investigate their effects on pathogenic species such as Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Streptococcus mutans.
Addressing the lack of diversity in STEM is a crucial step in eliminating sexism, racism, ableism, and other forms of discrimination in broader society. As a lab, we recognize that diversity breeds innovation and creativity by capitalizing on unique perspectives. We are committed to fostering an inclusive environment through increasing our personal awareness as well as promoting the advancement of under-represented groups in the sciences. Our lab members are involved in groups such as the Association for Women in Science (AWIS), the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChe), and the Society for the Advancement of Chicano and Native Americans in Science (SACNAS). Most of our members have also been Safe Space certified, providing them with training to better support the LGBTQ+ community. The Wuest Lab aspires to be a welcoming community for students and postdocs from any background.