Natural Product-Inspired Approaches to Combat Bacteria

The overarching goal of the Wuest research group is to utilize chemical biology to better understand bacterial processes. With the rise of the antibiotic crisis, we are interested in discovering new methods to combat bacterial resistance. Our group implements a variety of methods to interrogate these processes with the overarching goal of identifying novel treatments and new targets for pharmaceutical development. Most recently, we have switched our attention to developing narrow-spectrum agents and using chemical probes to learn more about resistance mechanisms. Nationally, only a few synthetic endeavors have approached this problem in a similar way thus positioning our group for therapeutic breakthroughs.

Here is the GRA feature on the Group’s Research in more general terms.

Explore below to learn about our ongoing projects!