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Justin Shapiro

Post-Doctoral Fellow (joined 2018)

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Project: Iron-Binding Natural Product Antibiotics from Marine Microbiomes

Bio: Justin is a post-doc in the Wuest lab. He completed his undergraduate studies at Rhodes College in Memphis, TN where he worked with Dr. Loretta Jackson-Hayes creating Protein Kinase C mutants of the fungus Aspergillus nidulans. He went on to complete his PhD in the lab of Dr. Tim Wencewicz at Washington University in St. Louis, studying the iron acquisition systems of the human pathogen Acinetobacter baumannii using organic chemistry and microbiology. His interests in the Wuest lab include total synthesis and biological evaluation of natural products and analogs as potential antibiotics. Outside of lab he enjoys going to the gym, cooking, and spending time with friends/family. Justin’s goal is to be a PI and run his own academic research lab.

Awards: Graduate Student/Postdoctoral Fellow Travel Award, ACS 249th National Meeting, Division of Biological Chemistry


  1. Daniel C. Bailey, Tabbetha J. Bohac, Justin A. Shapiro, Daryl E. Giblin, Timothy A. Wencewicz, Andrew M. Gulick, “Crystal Structure of the Siderophore Binding Protein BauB Bound to an Unusual 2:1 Complex Between Acinetobactin and Ferric Iron.” Biochemistry, 2018, Accepted Article, DOI: 10.1021/acs.biochem.8b00986
  2. Justin A. Shapiro, John J. Varga, Derek Parsonage, William Walton, Matthew R. Redinbo, Larry J. Ross, E. Lucile White, Robert Bostwick, William M. Wuest, Al Claiborne, Joanna B. Goldberg, “Identification of Specific and Non‐specific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK).” ChemMedChem, 2018, Accepted Article DOI: 10.1002/cmdc.201800652
  3. Justin A. Shapiro,* Kelly R. Morrison,* Shreya S. Chodisetty, Djamaladdin G. Musaev, William M. Wuest, “Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product.” OrgLett, 2018, 20, 5922-5926. DOI: 10.1021/acs.orglett.8b02599 *Co-first authors
  4. Justin A. Shapiro, Anna R. Kaplan, William M. Wuest, “From General to Specific: Can Pseudomonas Primary Metabolism Be Exploited for Narrow-Spectrum Antibiotics?” ChemBioChem, 2018, 19, 1-7. DOI:
  5. Tabbetha J. Bohac,* Justin A. Shapiro,* Timothy A. Wencewicz, “Rigid Oxazole Acinetobactin Analog Blocks Siderophore Cycling in Acinetobacter baumannii.” ACS Infect. Dis. 2017, 3, 802-806. DOI: 10.1021/acsinfecdis.7b00146 *Co-first authors
  6. Justin A. Shapiro, Timothy A. Wencewicz, “Structure-Function Studies of Acinetobactin Analogs.” Metallomics, 2017, 9, 463-470. Inside cover. DOI: 10.1039/C7MT00064B
  7. Justin A. Shapiro, Timothy A. Wencewicz, “Acinetobactin Isomerization Enables Adaptive Iron Acquisition in Acinetobacter baumannii through pH-Triggered Siderophore Swapping.” ACS Infect. Dis., 2016, 2, 157-168. Front Cover. DOI: 10.1021/acsinfecdis.5b00145
  8. Loretta Jackson-Hayes, Terry W. Hill, Darlene M. Loprete, Claire E. DelBove, Justin A. Shapiro, Jordan Henley, Omolola O. Dawodu, “Two Amino Acid Sequences Direct Aspergillus nidulans Protein Kinase C (PkcA) Localization to Hyphal Apices and Septation Sites.” Mycologia 2014, 107, 452-459. DOI: 10.3852/14-217