Independent Career (undergraduate authors, co-first authors# )
2023
114. Submitted
113. Submitted
112. Submitted
111. Mahoney, A.R.; Storek, K.M.; Wuest, W.M.* “Structure-based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance” ACS Omega 2023 ASAP DOI: 10.1021/acsomega.3c00884
110. Huang, X.; Pan, W.; Zhong, M-Z.; Chhonker. Y.S.; Steele, A.D.; Keohane, C.E.; Mishra, B.; Lucas, O.F.R.; Murry. D.J.; Ausubel, F.M.; Wuest. W.M.; Li, C-X.; Mylonakis. E.* “Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection” Antimicrobial Agents and Chemotherapy 2023 ASAP DOI: 10.1128/aac.01679-22
109. Kavanaugh. L.G.#; Mahoney, A.R.#; Dey, D.; Wuest, W.M.*; Conn, G.L. “Berberine dimers as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition” bioRxiv 2023 DOI: 10.1101/2023.03.24.533986
108. Brayton, S.R.; Toles, Z.E.A.; Sanchez, C.A.; Michaud, M.E.; Thierer L.M.; Keller, T.M.; Risener, C.J.; Quave, C.L.; Wuest, W.M.*; Minbiole, K.P.C.* “Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents” ACS Infectious Diseases 2023 ASAP DOI: 10.1021/acsinfecdis.2c00624
107. Toles, Z.E.A.; Wu, A.; Sanchez, C.A.; Michaud, M.E.; Thierer, L.M.; Wuest, W.M.*; Minbiole, K.P.C.* “Double BAC and Triple BAC: A Systematic Analysis of the Disinfectant Properties of Multicationic Derivatives of Benzylalkonium Chloride (BAC)” ChemMedChem 2023 ASAP DOI: 10.1002/cmdc.202300018
106. Jeremia, L.; Deprez, B.; Dey, D.; Conn, G.L.*; Wuest, W.M.* “Ribosome-Targeting Antibiotics and Resistance via Ribosomal RNA Methylation” RSC Medicinal Chemistry 2023 ASAP (Invited Review for Special Issue on Antibiotic Resistance) DOI: 10.1039/D2MD00459C
105. Thierer, L.M.; Peterson, A.A.; Michaud, M.E.; Sanchez, C.A.; Brayton, S.; Wuest, W.M.*; Minbiole, K.P.C.* “Atom Economical QPCs: Phenyl-free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants” ACS Infectious Diseases 2023 ASAP DOI: 10.1021/acsinfecdis.2c00575
104. Cruz, R.; Wuest, W.M.* “Beyond ergosterol: Strategies for combatting antifungal resistance in Aspergillus fumigatus and Candida auris” Tetrahedron 2023, 133268-133280 DOI: 10.1016/j.tet.2023.133268 (Tetrahedron Special Issue Honoring Prof. John Wood)
2022
103. Pan, B.; Wang, Y.; Lin, X.; Qin, M.; Ghaemi, S.; Ding, A.; Wang, S.; Al-Khalifa, S.; Minbiole, K.P.C.; Wuest, W.M.; Petersen, A.A.; Leitgeb, A.; Shehu, A.;* Zhao, L.* “Property-Controllable Generation of Quaternary Ammonium Compounds” IEEE Intl Conf on Bioinformatics and Biomedicine (BIBM) Workshops: Computational Structural Biology Workshop (CSBW). 2022 :1-8.
102. Wang, Y.; Ghaemi, S.; Ding, A.; Du, Y.; Pan, B.; Qin, M.; Lin, X.; Petersen, A.A.; Leitgeb, A.; Al-Khalifa, S.; Minbiole, K.P.C.; Wuest, W.M.; Zhao, L.;* Shehu, A.* “Generation and Characterization of Quaternary Ammonium Compounds via Deep Learning” IEEE Intl Conf on Bioinformatics and Biomedicine (BIBM) Workshops: Computational Structural Biology Workshop (CSBW). 2022 :1-8.
101. Wang, S.; Guo, X.; Ling, M.; Pan, B.; Du, Y.; Wang, Y.; Ye, Y.; Petersen, A.A.; Leitgeb, A.; Al-Khalifa, S.; Minbiole, K.P.C.; Wuest, W.M.; Shehu, A.*; Zhao, L.* “Multi-objective Deep Data Generation with Correlated Property Control” Advances in Neural Information Processing Systems (NeurIPS). 2022 Available from: openreview.net/forum?id=3uj_8G7fxgs
100. Michaud, M.E.; Allen, R.A.; Morrison-Lewis. K.R.; Sanchez, C.A.; Minbiole, K.P.C.*; Post, S.J.*; Wuest, W.M.* “Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates” ACS Infectious Diseases 2022 8, 2307-2314 DOI: 10.1021/acsinfecdis.2c00382
99. Wilt, I.K.; Demeritte, A.R.; Wang, W.; Wuest, W.M.* “Total Synthesis and Antibacterial Investigations of 1-Hydroxyboivinianin A” ChemMedChem 2022 ASAP DOI: 10.1002/cmdc.202200363 (Highlighted as a Very Important Paper)
98. Spahr, A.C.; Michaud, M.E.; Amoo, L.E.; Sanchez, C.A.; Hogue, C. E.; Thierer, L.M.; Gau, M.R.; Wuest, W.M.*; Minbiole, K.P.C.* “Rigidity-Activity Relationships of bisQPC Scaffolds against Pathogenic Bacteria” ChemMedChem 2022, ASAP DOI: 10.1002/cmdc.202200224
97. Cheng, A.V.C.#; Cory, M.B.#; Li, A.; Kohli, R.M.*; Wuest, W.M.* “Exploration of inhibitors of the bacterial LexA repressor-protease” Bioorg. Med. Chem. Lett. 2022 65, 128702. DOI: 10.1016/j.bmcl.2022.128702
96. Dekarske, M.M.; Felix, L.O.; Ortiz, C.O.; Csatary, E.E.; Mylonakis, E.; Wuest, W.M.* “nTZDpa (non-thiazolidinedione PPARγ partial agonist) derivatives retain antimicrobial activity without improving renal toxicity” Bioorg. Med. Chem. Lett. 2022 64, 128678. DOI: 10.1016/j.bmcl.2022.128678
95. Sommers, K.J.#; Michaud, M.E.#; Hogue, C.E.; Scharnow, A.M.; Amoo, L.E.; Peterson, A.A.; Carden, R.G.; Minbiole, K.P.C.*; Wuest. W.M.* “Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles to Evade Disinfectant Resistance” ACS Infectious Diseases 2022 8, 387. DOI: 10.1021/acsinfecdis.1c00611
2021
94. Cheng, A. V.; Wuest, W.M. Antibacterials 2021 DOI: 10.1021/acs.infocus.7e4006 (Invited contributor for ACS In-Focus Series of E-books)
93. Shapiro, J.A.; Post, S.J.; Wuest, W.M.* “Total Synthesis of the Reported Structure of Cahuitamycin A” ChemRxiv 2021 DOI: 12702137
92. Schrank, C.L.; Wilt, I.K.; Monteagudo, C.O.; Haney, B.A.; Wuest, W.M.* “Using membrane perturbing small molecules to target chronic persistent infections” RSC Medicinal Chemistry 2021 12, 1312 DOI: 10.1039/D1MD00151E (Invited Review)
91. Kaplan, A.R.; Wuest, W.M.* “Promiscuous Pseudomonas: Uptake of non-endogenous ligands for iron acquisition” Tetrahedron Letters 2021 75, 153204 DOI: 10.1016/j.tetlet.2021.153204 (Tetrahedron Special Issue honoring Dale Boger)
90. Scharnow, A.M.; Wuest, W.M.* “Mining for mouth metabolites” Nature Chemical Biology 2021 17, 505 DOI: 10.1038/s41589-021-00784-9 (Invited Highlight)
89. Kaplan, A. R.#; Schrank, C.L.#; Wuest, W.M.* “An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation” ChemMedChem 2021 16, 2487 DOI: 10.1002/cmdc.202100134 (highlighted as a Very Important Paper; selected for cover art)
88. Mahoney, A.R.; Safaee, M.M.; Wuest, W.M.; Furst, A.L.* “The Silent Pandemic: Emergent Antibiotic Resistances Following the Global Response to SARS-CoV-2” iScience 2021 24, 102304 DOI: 10.1016/j.isci.2021.102304
87. Kaplan, A.R.; Musaev, D.G.; Wuest, W.M.* “Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonas Demonstrating Siderophore-like Activity” ACS Infectious Diseases 2021 7, 544 DOI: 10.1021/acsinfecdis.0c00897
86. Feliciano, J.A.; Leitgeb, A.J.; Schrank, C.L.; Allen, R.A.; Wuest, W.M.*; Minbiole, K.P.C.*; Carden, R.G.* “Trivalent Sulfonium Compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles” Bioorg. Med. Chem. Lett. 2021 37, 127809 DOI: 10.1016/j.bmcl.2021.127809
85. Hubner, I.; Shapiro, J.A.; Hobmann, J.; Drechsel, J.; Hacker, S.M.; Rather, P.N.; Piepar, D.H.; Wuest, W.M.; Sieber, S.A. “Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis” ACS Central Science 2021 7, 488 DOI: 10.1021/acscentralsci.0c01621
84. Zhang, W.#; Kaplan, A.R.#; Davison, E.K.; Freeman, J.L.; Brimble, M.A.; Wuest, W.M.* “Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development” Natural Product Reports 2021 38, 880 DOI: 10.1039/DONP00052C
83. Haney, B.A.#; Schrank, C.L.#; Wuest, W.M.* “Synthesis and biological evaluation of an antibacterial azaborine retinoid isostere” Tetrahedron Letters 2021 62, 152667 DOI:10.1016/j.tetlet.2020.152667 (Tetrahedron Special Issue honoring Dale Boger)
82. Sommers, K.J.; Bentley, B.S.; Carden, R.G.; Post, S.J.; Allen, R.A.; Kontos, R.C.; Black, J.W.; Wuest, W.M.*; Minbiole, K.P.C.* “Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures” ChemMedChem 2021 16, 467 DOI: 10.1002/cmdc.20200605
81. Garrison, M.A.#; Mahoney, A.R.#; Wuest, W.M.* “Tricepyridinium-inspired QACs yield potent antimicrobials and provide insight into QAC resistance” ChemMedChem 2021 16, 463 DOI: 10.1002/cmdc.202000604
80. Carden, R.G.*; Sommer, K.J.; Schrank, C. L.; Leitgeb, A.J.; Feliciano, J.A.; Wuest, W.M.*; Minbiole, K.P.C.* “Advancements in the Development of Non-Nitrogen-Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance” ChemMedChem 2021 15, 1974 DOI:10.1002/cmdc.202000612
79. Solinski, A.E.; Wuest, W.M.* “Collaboration in natural product total synthesis: Carolacton – a decade of discovery” Synlett 2021 32, 241 DOI: 10.1055/s-0040-1707244
2020
78. Demeritte, A.; Wuest, W.M. “A look around the West Indies: The spices of life are secondary metabolites” Bioorg. Med. Chem. 2020 28, 115792 DOI: 10.1016/j.bmc.2020.115792 (Tetrahedron Young Investigator special issue honoring Emily Balskus)
77. Davison, E.; Freeman, J.; Zhang, W.; Wuest, W.M.; Furkert, D.; Brimble, M.* “Asymmetric Total Synthesis of The Naturally Occurring Antibiotic Anthracimycin” Organic Letters 2020 22, 5550 DOI: 10.1021/acs/orglett/0c01913
76. Schrank, C.L.; Minbiole, K.P.C.*; Wuest, W.M.* “Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?” ACS Infectious Diseases 2020 6, 1553 DOI: 10.1021/acsinfecdis.0c00265
75. Schrank, C.L.; Danneman, M.; Prebihalo, E.A.; Wuest, W.M.; Mullins, R.J.* “Total synthesis of (+)-pilosinine via a stereodivergent conjugate addition strategy” Tetrahedron Letters 2020 61 151945 DOI: 10..1016/j.tetlet.2020.151945
74. Cross, A.R.; Csatary, E.E.; Raghuram, V.; Diggle, F.L.; Whiteley, M.; Wuest, W.M.; Goldberg, J.B.* “The histone-like protein AlgP regulon is distinct in mucoid and nonmucoid Pseudomonas aeruginosa and does not include alginate biosynthesis genes” Microbiology 2020 DOI: 10.1099/mic/0/000923
73. Ongwae, G.; Morrison, K.R.; Allen, R.A.; Kim, S.; Im, W.; Wuest, W.M.; Pires, M.M.* “Broadening Activity of Polymyxin by Quaternary Ammonium Grafting” ACS Infectious Diseases 2020 6, 1427 DOI: 10.1021/acsinfecdis.0c00037 (Antibiotics Special Issue)
72. Post, S.J.#; Keohane, C.E.#; Rossiter, L.M.; Kaplan, A.R.; Khowsathit, J.; Matuska, K.; Karanicolas, J.; Wuest, W.M.* “Target-based design of promysalin analogs identifies a new putative binding cleft in succinate dehydrogenase” ACS Infectious Diseases 2020 6, 1372 DOI: 10/1021/acsinfecdis.0c00024 (Antibiotics Special Issue)
71. Cheng, A.V.; Wuest, W.M.* “Phylogeny-guided Approach Yields Glycopeptides with Unique Action” Trends in Pharmacological Sciences 2020 41, 297 DOI: 10.1016/j.tips.2020.03.002 (Invited Highlight)
70. Cheng, A.V.#; Schrank, C.L.#; Escobar, I.E.; Mylonakis, E.; Wuest, W.M.* “Addition of ethylamines to the phenols of bithionol and synthetic retinoids does not elicit activity in gram-negative bacteria” Bioorg. Med. Chem. Lett. 2020 30, 127099 DOI: 10.1016/j.bmcl.2020.127099
69. Shaw, E.; Wuest, W.M.* “Virulence Attenuating Combination Therapy: A Potential Multi-target Approach to Treat Pseudomonas aeruginosa Infections in Cystic Fibrosis Patients” RSC Medicinal Chemistry 2020 11, 358 DOI: 10.1039/C9MD00566H
68. Leitgeb, A.J.; Feliciano, J.A.; Sanchez, H.; Allen, R.A.; Morrison, K.R.; Sommers, K.J.; Carden, R.; Wuest, W.M.*; Minbiole, K.P.C.* “Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics” ChemMedChem 2020 15, 1510 DOI: 10.1002/cmdc.201900662
67. Al-Khalifa, S.; Jennings, M.C.; Granata, D.; Klein, M.; Wuest, W.M.*; Minbiole, K.P.C.*; Carnevale, V.* “Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study” ChemBioChem 2020 21, 1510 DOI: 10.1002/cbic.201900698
66. Cheng, A.V.; Kim, W.; Escobar, I.E.; Mylonakis, E.; Wuest, W.M.* “Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids” ACS Med. Chem. Lett. 2020 11, 393 DOI: 10.1021/acsmedchemlett.9b00159 (Featured in the Women of Medicinal Chemistry Issue)
65. Le, P.; Kunold, E.; Macsics, R.; Rox, K.; Jennings, M.C.; Ugur, I.; Reinecke, M.; Chaves-Moreno, D.; Hackl, M.W.; Fetzer, C.; Mandl, F.A.M.; Lehmann, J.; Korotkov, V.S.; Hacker, S.M.; Kuster, B.; Antes, I.; Pieper, D.H.; Rohde, M.; Wuest, W.M.; Medina, E.; Sieber, S.A.* “Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms” Nature Chemistry 2020 12, 145 DOI: s41557-019-0378-7
64. Ochoa, C.#; Solinski, A.E.#; Nowlan, M.; Dekarske, M.M.; Wuest, W.M.*; Kozlowski, M.C.* “A bisphenolic honokiol analog outcompetes oral antimicrobial agent cetylpyridinium chloride via a membrane-associated mechanism” ACS Infectious Diseases 2020 6, 74 DOI: 10.1021/acsinfecdis.9b00190
2019
63. Kim, W.; Zou, G.; Hari, T.P.A.; Wilt, I.K.; Zhu, W.; Galle, N.; Faizi, H.A.; Hendricks, G.L.; Tori. K.; Pan, W.; Huang, X.; Steele, A.D.; Csatary, E.E.; Dekarske, M.M.; Rosen, J.L.; de Queiroz Ribiero, N.; Lee, K.; Port, J.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gao, H.; Ausubel, F.M.; Mylonakis,E. “A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus” Proc. Nat. Acad. Sci. 2019 116, 16529 DOI: 10.1073/pnas.1904700116 (Featured on NPR)
62. Morrison, K.R.; Allen, R.; Minbiole, K.P.C.*; Wuest, W.M.* “More QACs, more questions: recent advances in structure activity relationships and hurdles in understanding resistance mechanism” Tetrahedron Letters 2019 60, 150935 (Invited Digest) DOI: 10.1016/j.tetlet.2019.07.026
61. Korobeynikov, V.; Borakove, M.; Feng, Y.; Wuest, W.M.; Koval, A.B.; Nikonova, A.S.; Serebriiskii, I.; Chernoff, J.; Borges, V.F.; Golemis, E.A.; Shagisultanova, E.* “Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer” Breast Cancer Research & Treatment 2019 117, 369 DOI:10.1007/s10549-019-05329-2
60. Solinski, A.E.; Scharnow, A.M.; Fraboni, A.J., Wuest, W.M.* “Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans” ACS Infectious Diseases 2019 5, 1480 DOI:10.1021/acsinfecdis.9b00213
59. Zhao, W.; Cross, A.R.; Crowe-McAuliffe, C.; Weigert-Munoz, A.; Csatary, E.E.; Solinski, A.E.; Krysiak, J.; Goldberg, J.B.; Wilson, D.N.; Medina, E.; Wuest, W.M.; Sieber S.A.* “The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa“Angew. Chem. Int. Ed. 2019 58, 8581 DOI: 10.1002/anie.201903472
58. Wilt, I.K.; Hari, T.P.A.; Wuest, W.M.* “Hijacking Bacterial Circuitry of Biofilm Processes via Chemical “Hot-wiring”: An Under-explored Avenue for Therapeutic Development” ACS Infectious Diseases 2019 5, 789 DOI: 10.1021/acsinfecdis.9b00104 (Invited Viewpoint)
57. Cheng, A.V.; Wuest, W.M.* “Signed, Sealed, Delivered: Conjugate and Prodrug Strategies as Targeted Delivery Vectors for Antibiotics” ACS Infectious Diseases 2019 5, 816 DOI: 10.1021/acsinfecdis.9b00019
56. Post, S.J.; Shapiro, J.A.; Wuest, W.M.* “Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance” MedChemComm 2019 10, 505 (Invited review for the Antibiotic Resistance Issue) DOI: 10.1039/C9MD000032A
55. Scharnow, A.M.; Solinski, A.E.; Wuest, W.M.* “Targeting S. mutans biofilms: A perspective on preventing dental caries” MedChemComm 2019 10 , 1057 (Invited review for the New Talent Collection) DOI: 10.1039/C9MD00015A
54. Kontos, R.C.; Schallenhammer, S.A.; Bentley, B.S.; Morrison, K.R.; Feliciano, J.A.; Tasca, J.A.; Kaplan, A.R.; Bezpalko, M.W.; Kassel, S.W.; Wuest, W.M.*; Minbiole, K.P.C.* “An Investigation into Rigidity-Activity Relationships in bisQAC Amphiphilic Antiseptics” ChemMedChem 2019 14, 83 DOI: 10.1002/cmdc.201800622
53. Shapiro, J.A.; Varga, J.J.; Parsonage, D.; Walton, W.; Redinbo, M.R.; Ross, L.J.; White, E.L.; Bostwick, R.*; Wuest, W.M.*; Clairborne, A.*; Goldberg, J.B.* “Identification of Specific and Non-specific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)” ChemMedChem 2019 14, 78 DOI: 10.1002/cmdc.201800652
52. Shapiro, J.A.; Kaplan, A.R.; Wuest, W.M.* “From General to Specific: Can Primary Metabolism in Pseudomonas be Exploited for Narrow-Spectrum Antibiotics?” ChemBioChem 2019 20, 34 DOI: 10.1002/cbic.201800383 (Invited Concept, highlighted in the 20th Anniversary Issue)
2018
51. Kearney, S.E.; Zahoransky-Kohalmi, G.; et al. “Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space” ACS Central Science 2018 4, 1727 DOI: 10.1021/acscentsci.8b00747
50. Ernouf, G.; Wilt, I.K.; Zahim, S.; Wuest, W.M.* “Epoxy isonitriles, a unique class of antibiotics – Synthesis of their metabolites and biological investigations” ChemBioChem 2018 19, 2448 (Selected for ChemBio Talents Issue) DOI: 10.1002/cbic
49. Shapiro, J.A.#; Morrison, K.R.#; Chodisetty, S.S.; Musaev, D.G.; Wuest, W.M.* “Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product” Organic Letters 2018 20, 5922. DOI: 10.1021/acs.orglett.8b02599
48. Kim, W.; Steele, A.D.; Zhu, W.; Csatary, E.E.; Fricke, N.; Dekarske, M.M.; Jayamani, E.; Pan, W.; Kwon, B.; Sinitsa, I.F.; Rosen, J.; Conery, A.L.; Fuchs, B.B.; Vlahovska, P.M.; Ausubel, F.M.; Gao, H.; Wuest, W.M.*; Mylonakis, E. “Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters” ACS Infectious Diseases 2018 4, 1540 DOI: 10.1021/acsinfecdis.8b00161
47. Giglio, K.; Keohane, C.E.; Stodghill, P.; Steele, A.D.; Fetzer, C.; Sieber, S.A.; Filiatrault, M.J.*; Wuest, W.M.* ” Transcriptomic profiling suggest that Promysalin alters metabolic flux, motility, and iron regulation in Pseudomonas putida KT2440″ ACS Infectious Diseases 2018 4, 1179. DOI: 10.1021/acsinfecdis.8b00041
46. Kim, W.; Zhu, W.; Hendricks, G.L.; Van Tyne, D.; Steele, A.D.; Keohane, C.E.; Fricke, N.; Conery, A.L.; Shen, S.; Pan, W.; Lee, K.; Rajamuthiah, R.; Fuchs, B.B.; Vlahovska, P.M.; Wuest, W.M.; Gilmore, M.S.; Gao, H.; Ausubel, F.M.; Mylonakis, E. “A new class of synthetic retinoid antibiotics effective against bacterial persisters” Nature 2018 556, 103. DOI: 10.1038/nature26157
45. Blanchet, M.; Borselli, D.; Rodallec, A.; Peiretti, F.; Vidal, N.; Bolla, J.M.; Digiorgio, C.; Morrison, K.R.; Wuest, W.M.; Brunel, J.M* “Claramines: A new class of broad-spectrum antimicrobial agents with bimodal activity” ChemMedChem 2018 13, 1018 DOI: 10.1002/cmdc.201800073
44. Hofbauer, B.; Vomacka, J.; Stahl, M.; Korotkov, V.; Jennings, M.C.; Wuest, W.M.; Sieber, S.A.* “A dual inhibitor of Staphylococcus aureus virulence and biofilm attenuates expression of major toxins and adhesins” Biochemistry 2018 57, 1814. DOI: 10.1021/acs.biochem.7b01271
43. Steele, A.D.; Ernouf, G.; Lee, Y-E.; Wuest, W.M.* “Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action” Organic Letters 2018 20, 1126 DOI: 10.1021/acs.orglett.8b00054
42. Keohane, C.E.; Steele, A.D.; Fetzer, C.; Khowsathit, J.; Van Tyne, D.; Moynie, L.; Gilmore, M.S.; Karanicolas, J.; Sieber, S.A.; Wuest, W.M.* “Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase” J. Am. Chem. Soc. 2018 140, 1774 DOI: 10.1021/jacs.7b11212
41. Solinski, A.E.#; Ochoa, C.#; Lee, Y-E.; Paniak, T.; Kozlowski, M.C.*; Wuest, W.M.* “Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria” ACS Infectious Diseases 2018 4, 118 DOI: 10.1021/acsinfecdis.7b00178
2017
40. Schallenhammer, S.A.; Duggan, S.M.; Morrison, K.R.; Bentley, B.S.; Wuest, W.M.*; Minbiole, K.P.C.* “Hybrid BisQACs: Potent Biscationic Quaternary Ammonium Compounds Merging the Structures of Two Commercial Antiseptics” ChemMedChem 2017 12, 1931 DOI: 10.1002/cmdc.201700597
39. Rossiter, S.E.; Wuest, W.M.* “ErosS enzyme from Aliivibrio fischeri plays Cupid to choanoflagellates” ChemBioChem 2017 18, 2298 DOI: 10.1002/cbic.201700552 (Invited Highlight)
38. Rossiter, S.E.; Fletcher, M.H.; Wuest, W.M.* “Natural Products as Platforms to Overcome Antibiotic Resistance” Chemical Reviews 2017 117, 12415 DOI: 10.1021/acs.chemrev.7b00283
37. Jennings, M.C.; Forman, M.E.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.* “Efflux Pumps May Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus” ChemBioChem 2017 18, 1573 DOI: 10.1002/cbic.201700233 (highlighted as a Very Important Paper, Selected as Cover Art)
36. Fletcher, M.H.; Burns-Lynch, C.E.; Knouse, K.W.; Abraham, L.T.; DeBrosse, C.W.; Wuest, W.M.* “A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method” RSC Adv. 2017 7, 29835. DOI: 10.1039/C7RA06045A
35. Solinski, A.E.#; Koval, A.B.#; Brzozowski, R.S.#; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest. W.M.* “Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms” J. Am. Chem. Soc. 2017 139, 7188. DOI: 10.1021/jacs.7b03879
34. Allen, R.A.; Jennings, M.C.; Mitchell, M.A.; Al-Khalifa, S.E.; Wuest, W.M.*; Minbiole, K.P.C.* “Ester- and Amide-containing MultiQACs: Exploring Multicationic Soft Antimicrobial Agents” Bioorg. Med. Chem. Lett. 2017 27, 2107. DOI: 10.1016/j.bmcl.2017.03.077
33. Brzozowski, R.S.; Wuest, W.M.* “Twelve-Membered Macrolactones: Privileged Scaffolds for the Development of New Therapeutics” Chemical Biology & Drug Design 2017 89, 169 (invited review) DOI: 10.1111/cbdd.12783
32. Al-Khalifa, S.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.* “The Development of Next Generation Pyridinium-Based multiQAC Antiseptics” ChemMedChem 2017 12, 280
31. Zubris, D.L.*; Minbiole, K.P.C.*; Wuest, W.M.* “Polymeric Quaternary Ammonium Compounds: Versatile Antimicrobial Materials.” Current Topics in Medicinal Chemistry 2017 17, 305 DOI: 10.2174/1568026616666160829155805
2016
30. Forman, M.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.* “Building a Better QAC: Branched Tetracationic Antiseptics” ChemMedChem 2016 11, 1401 (Highlighted on the back cover!) DOI: 10.1002/cmdc.201600176
29. Jennings, M.C.; Wuest, W.M.* “Natural Product-Inspired Approaches to Combat Bacteria” Tetrahedron 2016 72, 3547. DOI: 10.1016/j.tet.2016.04.064 (Editorial Preface for Tetrahedron Symposium-in-Print)
28. Minbiole, K.P.C.*; Jennings, M.C.; Ator, L.E.; Black, J.W.; Grenier, M.C.; LaDow, J.E.; Caran, K.L.; Seifert, K.; Wuest, W.M.* “From Antimicrobial Activity to Mechanism of Resistance: The Multifaceted Role of Simple Quaternary Ammonium Compounds in Bacterial Eradication” Tetrahedron 2016 72, 3559. DOI: 10.1016/j.tet.2016.01.014
27. Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.* “Diverted Total Synthesis of Promysalin Analogs Demonstrates that an Iron-Binding Motif is Responsible for its Narrow-spectrum Antibacterial Activity” J. Am. Chem. Soc. 2016 138, 5833. DOI: 10.1021/jacs.6b03373
26. Forman, M.E.; Fletcher, M.H.; Jennings, M.C.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.* “Structure-Resistance Relationships: Interrogating Antiseptic Resistance in Bacteria with Multicationic Quaternary Ammonium Dyes” ChemMedChem 2016 11, 958. DOI: 10.1002/cmdc.201600095
25. Knouse, K.W.; Wuest, W.M.* “The Enantioselective Synthesis and Biological Evaluation of Chimeric Promysalin Analogs Facilitated by Diverted Total Synthesis” J. Antibiotics 2016 69, 337. DOI: 10.1038/ja.2016.4 (invited paper for Amos B. Smith, III issue)
24. Joyce, M.D.; Jennings, M.C.; Santiago, C.N.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.* “Natural Product-Derived Quaternary Ammonium Compounds with Potent Antimicrobial Activity” J. Antibiotics 2016 69, 344. DOI: 10.1038/ja.2015.107 (invited paper for A.B. Smith, III issue)
23. Koval, A.B.; Wuest, W.M.* “An optimized synthesis of the potent and selective Pak1 inhibitor FRAX-1036” Tetrahedron Lett. 2016 57, 449. DOI: 10.1016/j.tetlet.2015.12.059
2015
22. Keohane, C.E.; Steele, A.D.; Wuest, W.M.* “The rhizosphere microbiome: A playground for natural product chemists” Synlett 2015 26, 2739. DOI: 10.1055/s-0035-1560711 (invited Synpact Paper)
21. Mitchell, M.A.; Iannetta, A.A.; Jennings, M.C.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.* “Scaffold-hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials” ChemBioChem 2015 16, 2299. DOI: 10.1002/cbic.201500381 (highlighted as a Very Important Paper)
20. Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.* “Total Synthesis and Biological Evaluation of (-)-Promysalin” J. Am. Chem. Soc. 2015 137, 7314. DOI: 10.1021/jacs.5b04767
19. Jennings, M.C.; Minbiole, K.P.C.; Wuest, W.M.* “Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance” ACS Infectious Diseases, 2015 1, 288. DOI: 10.1021/acsinfecdis.5b00047
18. Jennings, M.C.; Buttaro, B.A.; Minbiole, K.P.C.; Wuest, W.M.* “Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus” ACS Infectious Diseases, 2015 1, 304. DOI: 10.1021/acsinfecdis.5b00032
17. Wakefield, A.E.; Wuest, W.M.; Voelz, V.A.* “Molecular Simulation of Conformational Pre-organization in Cyclic RGD Peptides.” J. Chem. Inf. Model, 2015 55, 806. DOI: 10.1021/ci500768u
2014
16. Paniak, T.J.; Jennings, M.C.; Shanahan, P.C.; Joyce, M.D.; Santiago, C.N.; Wuest, W.M.*; Minbiole, K.P.C.* “The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms.” Bioorg. Med. Chem. Lett. 2014 24, 5824. DOI: 10.1016/j.bmcl.2014.10.018
15. Kinzie, C.R.; Steele, A.D.; Pasciolla, S.M.; Wuest, W.M.* “Synthesis of cyclic dimeric methyl morpholinoside – a common synthetic precursor to cyclic dinucleotide analogs.” Tetrahedron Lett. 2014 55, 4966. DOI: 10.1016/j.tetlet.2014.07.038
14. Ator, L.C.; Jennings, M.C.; McGettigan, A.R.; Paul, J.J.; Wuest, W.M.*; Minbiole, K.P.C.* “Beyond paraquats: Dialkyl 3,3′- and 3,4′-bipyridinium amphiphiles as antibacterial agents” Bioorg. Med. Chem. Lett. 2014 24, 3706. DOI: 10.1016/j.bmcl.2014.07.024
13. Jennings, M.C.; Ator, L.C.; Paniak, T.J.; Minbiole, K.P.C.*; Wuest, W.M.* “Biofilm Eradicating Properties of Quaternary Ammonium Amphiphiles: Simple Mimics of Antimicrobial Peptides” ChemBioChem 2014 15, 2211. DOI: 10.1002/cbic.201402254
12. Fletcher, M.H.; Jennings, M.C.; Wuest, W.M.* “Draining the moat: Disrupting bacterial biofilms with natural products” Tetrahedron 2014 70, 6373. DOI: 10.1016/j.tet.2014.06.055 (invited review)
11. Wuest, W.M.*; Wuest, L.M* “Using Technology to Create an Active, Collaborative Learning Environment: Even in Organic Chemistry!” Proceedings of the 2014 Lilly Conference on College and University Teaching and Learning 2014 44.
10. Razavi, A. M.; Wuest, W.M.*; Voelz, V.A.* “Computational screening and selection of cyclic peptide hairpin mimetics by molecular simulation and kinetic network models.” J. Chem. Inf. Model. 2014 54, 1425. DOI: 10.1021/ci500102y
9. Hallside, M.S.; Brzozowski, R.S.; Wuest, W.M.*; Phillips, A.J.* “A Concise Synthesis of Carolacton” Org. Lett. 2014 16, 1148. DOI: 10.1021/ol500004k (Highlighted by Org. Lett. as a top 10 accessed article from Jan-Jun 2014)
8. Black, J.W.; Jennings, M.C.; Azarewicz, J.; Paniak, T.J.; Grenier, M.C.; Wuest, W.M.*; Minbiole, K.P.C.* “TMEDA-derived biscationic amphiphiles: An economical preparation of potent antibacterial agents” Bioorg. Med. Chem Lett. 2014 24, 99. DOI: 10.1016/j.bmcl.2013.11.070
Prior Publications (2008-2011)
7. Wuest, W.M.; Krahn, D.; Kaiser, M.; Walsh, C.T.*; “Enzymatic Timing and Tailoring of Macrolactomization in Syringolin Biosynthesis” Org. Lett. 2011 13, 4518. DOI:10.1021/ol2016687
6. Imker, H.J.; Walsh, C.T.*; Wuest, W.M. “SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A” J. Am. Chem. Soc. 2009 131, 18263. DOI: 10.1021/ja909170u
5. Wuest, W.M.; Sattely, E.S.; Walsh, C.T.* “Three Siderophores from One Bacterial Enzymatic Assembly Line” J. Am. Chem. Soc. 2009 131, 5056. DOI: 10.1021/ja900815w
4. Smith III, A.B.*; Wuest, W.M. “Evolution of Multi-Component Anion Relay Chemistry (ARC): Construction of Architecturally Complex Natural and Unnatural Products” Chem. Commun. 2008 45, 5883. DOI: 10.1039/B810394A
3. Smith III, A.B.*; Cox, J.M.; Furuichi, N.; Kenesky, C.S.; Zheng, J.; Atasoylu, O.; Wuest, W.M.; “Total Synthesis of (-)-2-epi-peloruside A” Org. Lett. 2008 10, 5501. DOI: 10.1021/ol8019132
2. Smith III, A.B.*; Kim, W.S.; Wuest, W.M.; “Ortho-TMS Benzaldehyde: an Effective Linchpin for Type II Anion Relay Chemistry (ARC)” Angew. Chem. Int. Ed. 2008 47, 7082. DOI: 10.1002/anie.200802301
1. Carney, J.M.; Donoghue, P.J.; Wuest, W.M.; Wiest, O.*; Helquist, P.* “Intramolecular Hydroamination of Aminoalkynes with Silver Phenanthroline Catalysts” Org. Lett. 2008 10, 3903. DOI: 10.1021/ol801458g