In his new post on Monster Models, Ben Recht explains why systems physiology modeling is so hard, and why just leaning harder into standard engineering principles cannot possibly be the…
Category: Mathematics
The Missing (Computational) Link
A powerful technique for generating insights into physiology is to mathematically express what we know about it, then to simulate it in a computer. With the mathematical expressions in hand…
The Case for, and Path to, a Mathematical Model of Urinary Tract Function
Imagine, if you would, a future where your favorite local urologist could tell you how many milliliters your bladder will void two years from now (given the details of your…
The Simple-As-Possible Approach to Lower Urinary Tract Simulation
“What I cannot build, I do not understand.” – Richard Feynman Since I go around pretending that I know how control of the lower urinary tract (LUT) works, surely I…
Very Simple Simulation of Very Simple Neurons
The fundamental unit of the brain is the neuron, and the computational essence of a neuron is adding up blips from neurons it listens to then “deciding” whether to issue…
How Much Pee is Left Inside? (Techniques for Basic Science Urology)
The most natural way to test how well the bladder and lower urinary tract (LUT) are working is to monitor what it does with urine in a process called cystometry…
NIDDK Grant to Revolutionize Mathematical Systems Physiology
I’m very excited to announce (September 2022 throwback) that NIDDK at NIH is supporting me to lead a big, interdisciplinary team to invent a new mathematical infrastructure to model the…