26. α-hydroxy esters as inexpensive chiral auxiliaries in rhodium(II)-catalyzed cyclopropanations with vinyldiazomethanes

Authors: Huw M.L. Davies, William R. Cantrell Jr.

Tetrahedron Lett.,

199132, 6509-6512

1-s2.0-004040399180206L-gr1

High levels of asymmetric induction were achieved in rhodium(II) catalyzed cyclopropanations with chiral vinyldiazomethanes. (R)-(−)-Pantolactone is the most effective chiral auxiliary, but other α-hydroxy esters also give reasonable levels of diastereoselectivity.

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