102. Asymmetric Catalytic C−H Activation Applied to the Synthesis of Syn-Aldol Products

Authors: Huw M. L. Davies and Evan G. Antoulinakis

Org. Lett.,

2000, 2 (26), 4153–4156


Rh2(R-DOSP)4-catalyzed decomposition of methyl phenyldiazoacetate in the presence of tetraalkoxysilanes results in the asymmetric synthesis of syn-aldol products. This catalytic asymmetric intermolecular C−H activation proceeds by means of a rhodium−carbene-induced C−H insertion.

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