145. Enantioselective Synthesis of Cyclopropylphosphonates Containing Quaternary Stereocenters Using a D2-Symmetric Chiral Catalyst Rh2(S-biTISP)2

Authors: Huw M. L. Davies and Gene H. Lee

Org. Lett.,

2004, 6 (13), 2117–2120

Rh2(S-biTISP)2-catalyzed reactions of dimethyl aryldiazomethylphosphonates generate donor/acceptor-substituted rhodium carbenoid intermediates capable of cyclopropanation of styrenes in high yields (85−96%), diastereoselectivity (≥98% de), and enantioselectivity (76−92% ee).

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