Authors: Justin R. Denton , Dinesh Sukumaran , and Huw M. L. Davies
Org. Lett.,
2007, 9 (14), 2625–2628
The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh2(R-PTAD)4, generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (>94%) and enantioselectivity (88−>98%).