Authors: Hengbin Wang, Gang Li, Keary M. Engle, Jin-Quan Yu , and Huw M. L. Davies
J. Am. Chem. Soc.,
2013, 135 (18), 6774–6777
The enantioselective synthesis of 2,3-dihydrobenzofurans was achieved by using two sequential C–H functionalization reactions, a rhodium-catalyzed enantioselective intermolecular C–H insertion followed by a palladium-catalyzed C–H activation/C–O cyclization. Further diversification of the 2,3-dihydrobenzofuran structures was possible by a subsequent palladium-catalyzed intermolecular Heck-type sp2 C–H functionalization.