Impact of CFTR Modulation on Pseudomonas aeruginosa Infection in People With Cystic Fibrosis
Ledger, E. L., Smith, D.J., Teh, J. J., Wood, M. E., Whibley, P., Morrison, M., Goldberg, J. B., Reid, D. W., and Wells, T. J.  Journal of Infectious Diseases, jiae051. 

Experimentally evolved Staphylococcus aureus shows increased survival in the presence of Pseudomonas aeruginosa by acquiring mutations in the amino acid transporter, GltT
Alexander, A.M., Luu, J.M., Raghuram V., Bottacin G., Vliet, S. van., Read, T.D., Goldberg, J.B. Microbiology, 170:001445. PMCID: PMC10999751.

Factor H-related protein 1 promotes complement-mediated opsonization of Pseudomonas aeruginosa
González-Alsina, A., Merinero, H. M., Mateu-Borrás, M., Verd, M., Doménech-Sánchez, A.,  Goldberg, J. B., Rodriguez De Cordoba S., and Albertí, S. Frontiers in Cellular and Infectious Microbiology, 14:1328185.  PMCID:PMC10951071

A role for the stringent response in ciprofloxacin resistance in Pseudomonas aeruginosa
Garcia Villada, L., Degtyareva, N., Brooks, A., Goldberg, J. B., and Doetsch P. Scientific Reports. PMCID: PMC11016087

Mutation of hmgA, encoding homogentisate 1,2-dioxygenase, is responsible for pyomelanin production, but does not impact the virulence of Burkholderia cenocepacia in a chronic granulomatous disease mouse lung infection. Moustafa, D. A., Wu, L., Ivey, M., Fankhauser, S.C., and Goldberg, J.B.  Microbiology Spectrum, 12:e00410-24. PMCID: PMC11218447

Application of a quantitative framework to improve the accuracy of a bacterial infection model
Lewin, G. R., A. Kapur, D. M. Cornforth, R. P. Duncan, F. L. Diggle, D. A. Moustafa, S. A. Harrison, E. P. Skaar, W. J. Chazin, J. B. Goldberg, J. M. Bomberger, and M. Whiteley. –Proceedings of the National Academy of Sciences, 120:e2221542120. PMCID: PMC10175807

A Pseudomonas aeruginosa small RNA regulates chronic and acute infection. 
Cao, P., D. Fleming, K. H. Szymanik, D. A. Moustafa, W. K. Redman, S. K. Dolan, A. Ramos, F. L. Diggle, J. B. Goldberg, C. S. Sullivan, K. P. Rumbaugh, and M. Whiteley. – Nature, 618:358-364. PMCID: PMC10247376

Short chain fatty acids reduce the respiratory burst of human neutrophils in response to cystic fibrosis isolates of Staphylococcus aureus. 
Miller, A., K. M. Fantone, S. L. Tucker, N. Gokanapudi, J. B. Goldberg, and B. Rada B. –Journal of Cystic Fibrosis 22:756-762.

Sequence specificity defines the effectiveness of PPMOs targeting Pseudomonas aeruginosa.  Nanayakkara, A. K., D. A. Moustafa, R. Pifer, J. B. Goldberg, and D. E. Greenberg. – Antimicrobial Agents and Chemotherapy 67:e0024523.  PMCID:PMC10508178

Sputum from people with cystic fibrosis reduces the killing of methicillin-resistant Staphylococcus aureus by neutrophils and diminishes phagosomal production of reactive oxygen species. 
Fantone, K. M, J. B Goldberg, A. A Stecenko, and B. Rada. – Pathogens 12:1148.  PMCID:PMC10538153

The type VI secretion system of the emerging pathogen Stenotrophomonas maltophilia has antibacterial properties.
Crisan, C. V., D. Van Tyne, and J. B. Goldberg. – mSphere 8:e0058423.  PMCID:PMC10732056

Efficacy of a Pseudomonas aeruginosa serogroup O9 vaccine. 
Moustafa, D., A. DiGiandomenico, V. Raghuram, M. Schulman, J. Scarff, M. Davis, J. Varga, C. Dean, and J. Goldberg. – Infection and Immunity 91:e0024723.  PMCID:PMC10715167

Complete Genome Sequence of Stenotrophomonas maltophilia complex strain STEN00241.
Crisan, C. V., R. P. Duncan, D. Van Tyne, and J. B. Goldberg. – Microbiology Resource Announcements e0105325.

The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa

Taylor, I. R., P. D. Jeffrey, D. A. Moustafa, J. B. Goldberg, and Bonnie L. Bassler. Biochemistry. PubMed: PMID: 35985643

Pseudomonas aeruginosa antivirulence strategies: targeting the type III secretion system

Goldberg, J. B., C. V. Crisan, and J. M. Luu. In Pseudomonas aeruginosa: biology, pathogenesis and control strategies (Ed.  J.-L. Ramos and A. Filloux), Springer-Nature.  Advances in Experimental Medicine and Biology, volume 1386. PubMed: PMID: 36258075

Staphylococcus aureus and Pseudomonas aeruginosa Isolates from the Same Cystic Fibrosis Respiratory Sample Coexist in Coculture.

Bernardy E.E., V. Raghuram, J.B. Goldberg. Microbiol Spectr. PubMed:PMID: 35867391.

Bacteriophage-Loaded Poly(lactic-co-glycolic acid) Microparticles Mitigate Staphylococcus aureus Infection and Cocultures of Staphylococcus aureus and Pseudomonas aeruginosa.

Kalelkar P.P., D.A. Moustafa, M. Riddick, J.B. Goldberg, N.A. McCarty, A.J. García. Adv Healthc Mater. PubMed:PMID: 34957709.

Antibacterial contact-dependent proteins secreted by Gram-negative cystic fibrosis respiratory pathogens.

Crisan C.V., J. B. Goldberg. Trends Microbiol. PubMed:PMID: 35487848.

Pseudomonas aeruginosa inflammasome activation attenuated by the PGC-1alpha-SIRT3 pathway

Maurice, N. M., B. Bedi, Z. Yuan, K.-C. Lin, J. B. Goldberg, C. M. Hart, K. L. Bailey, R. T. Sadikot. – Pathogens. PubMed:PMCID: PMC8875424

Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections

Chung, H., C. Merakou, M. Schaefers, K. Flett, S. Martini, R. Lu, J. Blumenthal, S. Webster, A. Cross, R. Al Ahmar, E. Halpin, M. Anderson, N. Moore, E. Snesrud, H. Yu, J. Goldberg, G. O’Toole, P. McGann, J. Stam, M. Hinkle, A. McAdam, R. Kishony, and G. Priebe.  – Nature Communications. PubMed:PMID: 35264582.

Species-wide phylogenomics of the Staphylococcus aureus agr operon reveals convergent evolution of frameshift mutations

Raghuram, V., A. M. Alexander, H. Q. Loo, R. A. Petit III, J. B. Goldberg, and T D. Read.  – Microbiology Spectrum. PubMed:PMCID:PMC8768832

The Pseudomonas aeruginosa whole genome sequence: A 20th anniversary celebration

Brinkman, F., G. Winsor, R. E. Done, A. Filloux, V. I. Francis, J. B. Goldberg, E. P. Greenberg, K. Han, R. E. W. Hancock, C. H. Haney, S. Häußler, J. Klockgether, I. Lamont, R. C. Levesque, S. Lory, P. I. Nikel, S. L. Porter, M. W. Scurlock, H. P. Schweizer, B. Tümmler, M. Wang and M. Welch.  – Advances in Microbial Physiology. PubMed:PMID: 34836612

Model systems to study the chronic, polymicrobial infections in cystic fibrosis: current approaches and exploring future directions

O’Toole, G., A. Crabbé, R. Kümmerli, J. J. LiPuma, J. M. Bomberger, J. C. Davies, D. Limoli, V. V. Phelan, J. B. Bliska, W. H. DePas, L. E. Dietrich, T. H. Hampton, R. Hunter, C. Khursigara, A. Price-Whelan, A. Ashare, R. A. Cramer, J. B. Goldberg, F. Harrison, D. A. Hogan, M. A. Henson, D. R. Madden, J. R. Mayers, C. Nadell, D. Newman, A. Prince, D. W. Rivett, J. D Schwartzman, D. Schultz, D. C. Sheppard, A. R. Smyth, M. A. Spero, B. A. Stanton, P. E. Turner, C. van der Gast, F. J. Whelan, R. Whitaker, and K. Whiteson. – mBio. PubMed:PMCID:PMC8546538

Vfr or CyaB promote the expression of the pore-forming toxin exlBA operon in Pseudomonas aeruginosa ATCC 9027 without increasing its virulence in mice

Reyes, S. G., D. A Moustafa, I. Atree, J. B. Goldberg, S. E. Quiroz-Morales, and G. Soberón-Chávez. – Microbiology. PubMed: PMID:34424157

O-specific antigen-dependent surface hydrophobicity mediates aggregate assembly type in Pseudomonas aeruginosa

Azimi, S., J. Thomas, S. E. Cleland, J. E. Curtis, J. B. Goldberg, and S. P. Diggle. – mbio. PubMed:PMCID:PMC8406328

Cystic fibrosis sputum impairs the ability of neutrophils to kill Staphylococcus aureus

Fantone, K. S. L. Tucker, A. B Miller, R. Yadav, E. E. Bernardy, R. Fricker, A. A Stecenko, J. B Goldberg, and B. Rada – Pathogens. PubMed: PMCID:PMC8229215

Microbiome data enhances predictive models of lung function in people with CF

Zhao, C. Y., Y. Wang, J. J. Varga, A. A. Stecenko, J. B. Goldberg, and S. P. Brown.  – Journal of Infectious Diseases. PubMed: PMCID:PMC8355460

Peptides and Antibiotic Therapy: Advances in Design and Delivery

Schafer ME, Browne H, Goldberg JB, Greenberg DE. – Acc Chem. PubMed: PMID: 33881843.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB , Greenberg DE. – mBio. PubMed: PMID: 33436433

Overproduction of the AlgT sigma factor is lethal to mucoid Pseudomonas aeruginosa.

 

The histone-like protein AlgP regulon is distinct in mucoid and nonmucoid Pseudomonas aeruginosa and does not include alginate biosynthesis genes.

 

UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis.

 

Role of Pseudomonas aeruginosa Glutathione Biosynthesis in Lung and Soft Tissue Infection.

 

Genotypic and Phenotypic Diversity of Staphylococcus aureus Isolates from Cystic Fibrosis Patient Lung Infections and Their Interactions with Pseudomonas aeruginosa.

 

Draft Genome Sequences of Eight Pseudomonas aeruginosa Corneal Infection Isolates.

Raghuram, V., J. B. Goldberg – Microbiology Resource Announcements. PubMed: PMID: 31896638

 

Substrate recognition by the Pseudomonas aeruginosa EF-Tu-modifying methyltransferase EftM.

Kuiper, E. G., D. Dey, P. A. LaMore, J. P. Owings, S. M. Prezioso, J. B. Goldberg, G. L. Conn – Journal of Biological Chemistry. PubMed: PMID: 31753919

 

Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction.

Maurice, N. M., B. Bedi, Z. Yuan, J. B. Goldberg, M. Koval, C. M. Hart, R. T. Sadikot
– Scientific Reports. PubMed: PMID: 31417101

 

The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.

Zhao, W., A. R. Cross, C. Crowe-McAuliffe, A. Weigert-Munoz, E. E. Csatary, A. E. Solinski, J. Krysiak, J. B. Goldberg, D. N. Wilson, E. Medina, W. M. Wuest, S. A. Sieber – Angewandte Chemie International Edition in English. PubMed: PMID: 30969469.

 

Pseudomonas aeruginosa in cystic fibrosis: A chronic cheater.

Waters, C. M., J. B. Goldberg – Proceedings of the National Academy of Sciences of the United States of America (PNAS). PubMed: PMID: 30890646.

 

Trimethylation of Elongation Factor-Tu by the Dual Thermoregulated Methyltransferase EftM Does Not Impact Its Canonical Function in Translation.

Prezioso, S. M., D. M. Duong, E. G. Kuiper, Q. Deng, S. Albertí, G. L. Conn, J. B. Goldberg – Scientific Reports. PubMed: PMID: 30837495.

 

Remodeling of O Antigen in Mucoid Pseudomonas aeruginosa via Transcriptional Repression of wzz2.

Cross, A. R., J. B. Goldberg – mBio. PubMed: PMID: 30782665.

 

Whole-Genome Sequences of Staphylococcus aureus Isolates from Cystic Fibrosis Lung Infections.

Bernardy, E. E., R. A. Petit, III, A. G. Moller, J. A. Blumenthal, A. J. McAdam, G. P. Priebe, A. T. Chande, L. Rishishwar, I. K. Jordan, T. D. Read, J. B. Goldberg – Microbiology Resource Announcements. PubMed: PMID: 30687841. 

 

Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK).

Shapiro, J.A., J. J. Varga, D. Parsonage, W. Walton, M. R. Redinbo, L. J. Ross, E. L. White, R. Bostwick, W. M. Wuest, A. Claiborne, J. B. Goldberg – ChemMedChem. PubMed: PMID: 30376607.

The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa.

Mukherjee, S., D. A. Moustafa, V. Stergioula, C. D. Smith, J. B. Goldberg, B. L. Bassler – Proceedings of the National Academy of Sciences of the United States of America (PNAS). PubMed: PMID: 30224496.

 

Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis.

Forrest, O. A., S. A. Ingersoll, M. K. Preininger, J. Laval, D. H. Limoli, M. R. Brown, F. E. Lee, B. Bedi, R. T. Sadikot, J. B. Goldberg, V. Tangpricha, A. Gaggar, R. Tirouvaniziam – Journal of leukocyte biology. PubMed: PMID: 29741792.

 

Pseudomonas aeruginosa AlgR Phosphorylation Status Differentially Regulates Pyocyanin and Pyoverdine Production.  

Little, A. S., Y. Okkotsu, A. A. Reinhart, F. H. Damron, M. Barbier, B. Barrett, A. G. Oglesby-Sherrouse, J. B. Goldberg, W. L. Cody, M. J. Schurr, M. L. Vasil, M. J. Schurr – mBio. PubMed: PMID: 29382736.

Sensing Mg²⁺ contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis.

Qadi, M., S. Izquierdo‐Rabassa, M. M. Borrás, A. Doménech‐Sánchez, C. Juan, J. B. Goldberg, R. E. W. Hancock, S. Albertí – Environmental Microbiology. PubMed: PMID: 28805355.

 

Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis.

Gorla, S. K., Y. Zhang, M. M. Rabideau, A. Qin, S. Chacko, A. L. House, C. R. Johnson, K. Mandapati, H. M. Bernstein, E. S. McKenney, H. Boshoff, M. Zhang, I. J. Glomski, J. B. Goldberg, G. D. Cuny, B. J. Mann, L. Hedstrom – Antimicrobial Agents and Chemotherapy. PubMed: PMID: 28739786.

 

The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer.

Mukherjee, S., D. Moustafa, C. D. Smith, J. B. Goldberg, B. L. Bassler – PLOS Pathogens. PubMed: PMID: 28715477.

 

Elfamycins: inhibitors of elongation factor-Tu.

Prezioso, S. M., N. E. Brown, J. B. Goldberg – Molecular Microbiology. PubMed: PMID: 28710887.

 

Peroxisome proliferator-activated receptor-γ agonists attenuate biofilm formation by Pseudomonas aeruginosa.

Bedi, B., N. M. Maurice, V. T. Ciavatta, K. S. Lynn, Z. Yuan, S. A. Molina, M. Joo, W. R. Tyor, J. B. Goldberg, M. Koval, C. M. Hart, and R. T. Sadikot – The FASEB Journal. PubMed: PMID: 28442545.

 

Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection.

Limoli, D. H., G. B. Whitfield, T. Kitao, M. L. Ivey, M. R. Davis Jr, N. Grahl, D. A. Hogan, L. G. Rahme, P. L. Howell, G. A. O’Toole, J. B. Goldberg – mBio. PubMed: PMID: 28325763.

 

Inhibition of Pseudomonas aeruginosa by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers.

Howard, J. J., C. R. Sturge, D. A. Moustafa, S. M. Daly, K. R. Marshall-Batty, C. F. Felder, D. Zamora, M. Yabe-Gill, M. Labandeira-Rey, S. M. Bailey, M. Wong, J. B. Goldberg, B. L. Geller, D. E. Greenberg – Antimicrobial Agents and Chemotherapy. PubMed: PMID: 28137807. 

Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa.

Floyd, M., M. Winn, C. Cullen, P. Sil, B. Chassaing, D. G. Yoo, A. T. Gewirtz, J. B. Goldberg, L. L. McCarter, B. Rada – PLOS Pathogens. PubMed: PMID: 27855208.

 

The Escherichia coli rhaSR-PrhaBAD Inducible Promoter System Allows Tightly Controlled Gene Expression over a Wide Range in Pseudomonas aeruginosa.

Meisner, J., J. B. Goldberg – Applied and Environmental Microbiology. PubMed: PMID: 27613678.

 

Surfactant Protein A Recognizes Outer Membrane Protein OprH on Pseudomonas aeruginosa Isolates From Individuals With Chronic Infection.

Qadi, M., C. Lopez-Causapé, S. Izquierdo-Rabassa, M. Mateu Borrás, J. B. Goldberg, A. Oliver, S. Albertí – The Journal of Infectious Diseases. PubMed: PMID: 27543671.

 

Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori.

Owings, J. P., N. N. McNair, Y. F. Mui, T. N. Gustafsson, A. Holmgren, M. Contel, J. B. Goldberg, J. R. Mead – FEMS Microbiology Letters. PubMed: PMID: 27279627.

 

Enhanced Clearance of Pseudomonas aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma.

Bedi, B., Z. Yuan, M. Joo, S. M. Zughaier, J. B. Goldberg, J. L. Arbiser, C. M. Hart, R. T. Sadikot – Infection and Immunity. PubMed: PMID: 27091928.

 

Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.

Owings, J. P., E. G. Kuiper, S. M. Prezioso, J. Meisner, J. J. Varga, N. Zelinskaya, E. B. Dammer, D. M. Duong, N. T. Seyfried, S. Albertí, G. L. Conn, J. B. Goldberg – The Journal of Biological Chemistry. PubMed: PMID: 26677219.

Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains.

Varga, J. J., M. Barbier, X. Mulet, P. Bielecki, J. A. Bartell, J. P. Owings, I. Martinez-Ramos, L. E. Hittle, M. R. Davis Jr., F. H. Damron, G. W. Liechti, J. Puchałka, V. A. dos Santos, R. K. Ernst, J. A. Papin, S. Albertí, A. Oliver, J. B. Goldberg – BMC Genomics. PubMed: PMID: 26519161.

 

Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders.

Moustafa, D. A., J. M. Scarff, P. P. Garcia, S. K. Cassidy, A. DiGiandomenico, D. M. Waag, T. J. Inzana, J. B. Goldberg – PLOS One. PubMed: PMID: 26148026.

 

Coevolution with bacteriophages drives genome-wide host evolution and constrains the acquisition of abiotic-beneficial mutations.

Scanlan, P. D., A. R. Hall, G. Blackshields, V. P. Friman, M. R. Davis Jr., J. B. Goldberg, A. Buckling – Molecular Biology and Evolution. PubMed: PMID: 25681383.

 

Single amino acid substitution in homogentisate 1,2-dioxygenase is responsible for pigmentation in a subset of Burkholderia cepacia complex isolates.

Gonyar, L. A., S. C. Fankhauser, J. B. Goldberg – Environmental Microbiology Reports. PubMed: PMID: 25294803.

Repurposing cryptosporidium inosine 5′-monophosphate dehydrogenase inhibitors as potential antibacterial agents.

Mandapati, K., S. K. Gorla, A. L. House, E. S. McKenney, M. Zhang, S. N. Rao, D. R. Gollapalli, B. J. Mann, J. B. Goldberg, G. D. Cuny, I. G. Glomski, L. Hedstrom – ACS Medicinal Chemistry Letters. PubMed: PMID: 25147601.

 

From the environment to the host: re-wiring of the transcriptome of Pseudomonas aeruginosa from 22°C to 37°C.

Barbier, M., F. H. Damron, P. Bielecki, M. Suárez-Diez, J. Puchałka, S. Albertí, V. M. Dos Santos, J. B. Goldberg – PLOS One. PubMed: PMID: 24587139.

 

Vaccines for Pseudomonas aeruginosa: a long and winding road.

Priebe, G. P., J. B. Goldberg – Expert Review of Vaccines. PubMed: PMID: 24575895.

 

Comparative metabolic systems analysis of pathogenic Burkholderia.

Bartell, J. A., P. Yen, J. J. Varga, J. B. Goldberg, J. A. Papin – Journal of Bacteriology. PubMed: PMID: 24163337.