Application of a quantitative framework to improve the accuracy of a bacterial infection model
Lewin, G. R., A. Kapur, D. M. Cornforth, R. P. Duncan, F. L. Diggle, D. A. Moustafa, S. A. Harrison, E. P. Skaar, W. J. Chazin, J. B. Goldberg, J. M. Bomberger, and M. Whiteley. –Proceedings of the National Academy of Sciences, 120:e2221542120. PMCID: PMC10175807

A Pseudomonas aeruginosa small RNA regulates chronic and acute infection. 
Cao, P., D. Fleming, K. H. Szymanik, D. A. Moustafa, W. K. Redman, S. K. Dolan, A. Ramos, F. L. Diggle, J. B. Goldberg, C. S. Sullivan, K. P. Rumbaugh, and M. Whiteley. – Nature, 618:358-364. PMCID: PMC10247376

Short chain fatty acids reduce the respiratory burst of human neutrophils in response to cystic fibrosis isolates of Staphylococcus aureus
Miller, A., K. M. Fantone, S. L. Tucker, N. Gokanapudi, J. B. Goldberg, and B. Rada B. –Journal of Cystic Fibrosis 22:756-762.

Sequence specificity defines the effectiveness of PPMOs targeting Pseudomonas aeruginosa Nanayakkara, A. K., D. A. Moustafa, R. Pifer, J. B. Goldberg, and D. E. Greenberg. – Antimicrobial Agents and Chemotherapy 67:e0024523.  PMCID:PMC10508178

Sputum from people with cystic fibrosis reduces the killing of methicillin-resistant Staphylococcus aureus by neutrophils and diminishes phagosomal production of reactive oxygen species. 
Fantone, K. M, J. B Goldberg, A. A Stecenko, and B. Rada. – Pathogens 12:1148.  PMCID:PMC10538153

The type VI secretion system of the emerging pathogen Stenotrophomonas maltophilia has antibacterial properties.
Crisan, C. V., D. Van Tyne, and J. B. Goldberg. – mSphere 8:e0058423.  PMCID:PMC10732056

Efficacy of a Pseudomonas aeruginosa serogroup O9 vaccine. 
Moustafa, D., A. DiGiandomenico, V. Raghuram, M. Schulman, J. Scarff, M. Davis, J. Varga, C. Dean, and J. Goldberg. – Infection and Immunity 91:e0024723.  PMCID:PMC10715167

Complete Genome Sequence of Stenotrophomonas maltophilia complex strain STEN00241.
Crisan, C. V., R. P. Duncan, D. Van Tyne, and J. B. Goldberg. – Microbiology Resource Announcements e0105325.

Impact of CFTR modulation on Pseudomonas aeruginosa infection in people with cystic fibrosis.
Ledger, E. L, D. J. Smith, J. J. Teh, M. E. Wood, P. Whibley, M. Morrison, J. B. Goldberg, D. W. Reid, and T. J. Wells.  Journal of Infectious Diseases, in press.

The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa

Taylor, I. R., P. D. Jeffrey, D. A. Moustafa, J. B. Goldberg, and Bonnie L. Bassler. Biochemistry. PubMed: PMID: 35985643

Pseudomonas aeruginosa antivirulence strategies: targeting the type III secretion system

Goldberg, J. B., C. V. Crisan, and J. M. Luu. In Pseudomonas aeruginosa: biology, pathogenesis and control strategies (Ed.  J.-L. Ramos and A. Filloux), Springer-Nature.  Advances in Experimental Medicine and Biology, volume 1386. PubMed: PMID: 36258075

Staphylococcus aureus and Pseudomonas aeruginosa Isolates from the Same Cystic Fibrosis Respiratory Sample Coexist in Coculture.

Bernardy E.E., V. Raghuram, J.B. Goldberg. Microbiol Spectr. PubMed:PMID: 35867391.

Bacteriophage-Loaded Poly(lactic-co-glycolic acid) Microparticles Mitigate Staphylococcus aureus Infection and Cocultures of Staphylococcus aureus and Pseudomonas aeruginosa.

Kalelkar P.P., D.A. Moustafa, M. Riddick, J.B. Goldberg, N.A. McCarty, A.J. García. Adv Healthc Mater. PubMed:PMID: 34957709.

Antibacterial contact-dependent proteins secreted by Gram-negative cystic fibrosis respiratory pathogens.

Crisan C.V., J. B. Goldberg. Trends Microbiol. PubMed:PMID: 35487848.

Pseudomonas aeruginosa inflammasome activation attenuated by the PGC-1alpha-SIRT3 pathway

Maurice, N. M., B. Bedi, Z. Yuan, K.-C. Lin, J. B. Goldberg, C. M. Hart, K. L. Bailey, R. T. Sadikot. – Pathogens. PubMed:PMCID: PMC8875424

Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections

Chung, H., C. Merakou, M. Schaefers, K. Flett, S. Martini, R. Lu, J. Blumenthal, S. Webster, A. Cross, R. Al Ahmar, E. Halpin, M. Anderson, N. Moore, E. Snesrud, H. Yu, J. Goldberg, G. O’Toole, P. McGann, J. Stam, M. Hinkle, A. McAdam, R. Kishony, and G. Priebe.  – Nature Communications. PubMed:PMID: 35264582.

Species-wide phylogenomics of the Staphylococcus aureus agr operon reveals convergent evolution of frameshift mutations

Raghuram, V., A. M. Alexander, H. Q. Loo, R. A. Petit III, J. B. Goldberg, and T D. Read.  – Microbiology SpectrumPubMed:PMCID:PMC8768832

The Pseudomonas aeruginosa whole genome sequence: A 20th anniversary celebration

Brinkman, F., G. Winsor, R. E. Done, A. Filloux, V. I. Francis, J. B. Goldberg, E. P. Greenberg, K. Han, R. E. W. Hancock, C. H. Haney, S. Häußler, J. Klockgether, I. Lamont, R. C. Levesque, S. Lory, P. I. Nikel, S. L. Porter, M. W. Scurlock, H. P. Schweizer, B. Tümmler, M. Wang and M. Welch.  – Advances in Microbial Physiology. PubMed:PMID: 34836612

Model systems to study the chronic, polymicrobial infections in cystic fibrosis: current approaches and exploring future directions

O’Toole, G., A. Crabbé, R. Kümmerli, J. J. LiPuma, J. M. Bomberger, J. C. Davies, D. Limoli, V. V. Phelan, J. B. Bliska, W. H. DePas, L. E. Dietrich, T. H. Hampton, R. Hunter, C. Khursigara, A. Price-Whelan, A. Ashare, R. A. Cramer, J. B. Goldberg, F. Harrison, D. A. Hogan, M. A. Henson, D. R. Madden, J. R. Mayers, C. Nadell, D. Newman, A. Prince, D. W. Rivett, J. D Schwartzman, D. Schultz, D. C. Sheppard, A. R. Smyth, M. A. Spero, B. A. Stanton, P. E. Turner, C. van der Gast, F. J. Whelan, R. Whitaker, and K. Whiteson. – mBio. PubMed:PMCID:PMC8546538

Vfr or CyaB promote the expression of the pore-forming toxin exlBA operon in Pseudomonas aeruginosa ATCC 9027 without increasing its virulence in mice

Reyes, S. G., D. A Moustafa, I. Atree, J. B. Goldberg, S. E. Quiroz-Morales, and G. Soberón-Chávez. – Microbiology. PubMed: PMID:34424157

O-specific antigen-dependent surface hydrophobicity mediates aggregate assembly type in Pseudomonas aeruginosa

Azimi, S., J. Thomas, S. E. Cleland, J. E. Curtis, J. B. Goldberg, and S. P. Diggle. – mbio. PubMed:PMCID:PMC8406328

Cystic fibrosis sputum impairs the ability of neutrophils to kill Staphylococcus aureus

Fantone, K. S. L. Tucker, A. B Miller, R. Yadav, E. E. Bernardy, R. Fricker, A. A Stecenko, J. B Goldberg, and B. Rada – Pathogens. PubMed: PMCID:PMC8229215

Microbiome data enhances predictive models of lung function in people with CF

Zhao, C. Y., Y. Wang, J. J. Varga, A. A. Stecenko, J. B. Goldberg, and S. P. Brown.  – Journal of Infectious Diseases. PubMed: PMCID:PMC8355460

Peptides and Antibiotic Therapy: Advances in Design and Delivery

Schafer ME, Browne H, Goldberg JB, Greenberg DE. – Acc Chem. PubMed: PMID: 33881843.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB , Greenberg DE.mBio. PubMed: PMID: 33436433

Overproduction of the AlgT sigma factor is lethal to mucoid Pseudomonas aeruginosa.

Cross AR, Raghuram V, Wang Z, Dey D, Goldberg JB – Journal of Bacteriology. PubMed: PMID: 32747430


The histone-like protein AlgP regulon is distinct in mucoid and nonmucoid Pseudomonas aeruginosa and does not include alginate biosynthesis genes.

Cross AR, Csatary EE, Raghuram V, Diggle FL, Whiteley M, Wuest WM, Goldberg JB – Microbiology. PubMed: PMID: 32634088


UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis.

Bedi B, Lin KC, Maurice NM, Yuan Z, Bijli K, Koval M, Hart CM, Goldberg JB, Stecenko A, Sadikot RT – Clinical Science. PubMed: PMID: 32537652


Role of Pseudomonas aeruginosa Glutathione Biosynthesis in Lung and Soft Tissue Infection.

Michie KL, Dees JL, Fleming D, Moustafa DA, Goldberg JB, Rumbaugh KP, Whiteley M.Infect Immun – Infection and Immunity. PubMed: PMID: 32284368


Genotypic and Phenotypic Diversity of Staphylococcus aureus Isolates from Cystic Fibrosis Patient Lung Infections and Their Interactions with Pseudomonas aeruginosa.

Bernardy EE, Petit RA 3rd, Raghuram V, Alexander AM, Read TD, Goldberg JB – mbio. PubMed: PMID: 32576671


Draft Genome Sequences of Eight Pseudomonas aeruginosa Corneal Infection Isolates.

Raghuram, V., J. B. Goldberg – Microbiology Resource Announcements. PubMed: PMID: 31896638


Differences in cystic fibrosis-associated Burkholderia spp. bacteria metabolomes after exposure to the antibiotic trimethoprim.

McAvoy, A., O. Jaiyesimi, P. Threatt, T. Seladi, J. B. Goldberg, R. da Silva, and N Garg – ACS Infectious Diseases. PubMed: PMID: 32212725

Substrate recognition by the Pseudomonas aeruginosa EF-Tu-modifying methyltransferase EftM.

Kuiper, E. G., D. Dey, P. A. LaMore, J. P. Owings, S. M. Prezioso, J. B. Goldberg, G. L. Conn – Journal of Biological Chemistry. PubMed: PMID: 31753919


Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction.

Maurice, N. M., B. Bedi, Z. Yuan, J. B. Goldberg, M. Koval, C. M. Hart, R. T. Sadikot
Scientific Reports. PubMed: PMID: 31417101


The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.

Zhao, W., A. R. Cross, C. Crowe-McAuliffe, A. Weigert-Munoz, E. E. Csatary, A. E. Solinski, J. Krysiak, J. B. Goldberg, D. N. Wilson, E. Medina, W. M. Wuest, S. A. Sieber – Angewandte Chemie International Edition in EnglishPubMed: PMID: 30969469.


Pseudomonas aeruginosa in cystic fibrosis: A chronic cheater.

Waters, C. M., J. B. Goldberg – Proceedings of the National Academy of Sciences of the United States of America (PNAS)PubMed: PMID: 30890646.


Trimethylation of Elongation Factor-Tu by the Dual Thermoregulated Methyltransferase EftM Does Not Impact Its Canonical Function in Translation.

Prezioso, S. M., D. M. Duong, E. G. Kuiper, Q. Deng, S. Albertí, G. L. Conn, J. B. Goldberg – Scientific Reports. PubMed: PMID: 30837495.


Remodeling of O Antigen in Mucoid Pseudomonas aeruginosa via Transcriptional Repression of wzz2.

Cross, A. R.J. B. Goldberg – mBio. PubMed: PMID: 30782665.


Whole-Genome Sequences of Staphylococcus aureus Isolates from Cystic Fibrosis Lung Infections.

Bernardy, E. E., R. A. Petit, III, A. G. Moller, J. A. Blumenthal, A. J. McAdam, G. P. Priebe, A. T. Chande, L. Rishishwar, I. K. Jordan, T. D. Read, J. B. Goldberg – Microbiology Resource AnnouncementsPubMed: PMID: 30687841. 


Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis TypeIII Pantothenate Kinase (PanK).

Shapiro, J.A., J. J. Varga, D. Parsonage, W. Walton, M. R. Redinbo, L. J. Ross, E. L. White, R. Bostwick, W. M. Wuest, A. Claiborne, J. B. Goldberg – ChemMedChemPubMed: PMID: 30376607.

The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa.

Mukherjee, S., D. A. Moustafa, V. Stergioula, C. D. Smith, J. B. Goldberg, B. L. Bassler – Proceedings of the National Academy of Sciences of the United States of America (PNAS)PubMed: PMID: 30224496.


Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis.

Forrest, O. A., S. A. Ingersoll, M. K. Preininger, J. Laval, D. H. Limoli, M. R. Brown, F. E. Lee, B. Bedi, R. T. Sadikot, J. B. Goldberg, V. Tangpricha, A. Gaggar, R. Tirouvaniziam – Journal of leukocyte biologyPubMed: PMID: 29741792.


Pseudomonas aeruginosa AlgR Phosphorylation Status Differentially Regulates Pyocyanin and Pyoverdine Production.  

Little, A. S., Y. Okkotsu, A. A. Reinhart, F. H. Damron, M. Barbier, B. Barrett, A. G. Oglesby-Sherrouse, J. B. Goldberg, W. L. Cody, M. J. Schurr, M. L. Vasil, M. J. Schurr – mBio. PubMed: PMID: 29382736.

Sensing Mg2+ contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis.

Qadi, M., S. Izquierdo‐Rabassa, M. M. Borrás, A. Doménech‐Sánchez, C. Juan, J. B. Goldberg, R. E. W. Hancock, S. Albertí – Environmental MicrobiologyPubMed: PMID: 28805355.


Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis.

Gorla, S. K.Y. ZhangM. M. RabideauA. QinS. ChackoA. L. HouseC. R. JohnsonK. MandapatiH. M. BernsteinE. S. McKenneyH. BoshoffM. ZhangI. J. GlomskiJ. B. GoldbergG. D. CunyB. J. MannL. Hedstrom – Antimicrobial Agents and Chemotherapy. PubMed: PMID: 28739786.


The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer.

Mukherjee, S., D. Moustafa, C. D. Smith, J. B. Goldberg, B. L. Bassler – PLOS PathogensPubMed: PMID: 28715477.


Elfamycins: inhibitors of elongation factor-Tu.

Prezioso, S. M., N. E. Brown, J. B. Goldberg – Molecular MicrobiologyPubMed: PMID: 28710887.


Peroxisome proliferator-activated receptor-γ agonists attenuate biofilm formation by Pseudomonas aeruginosa.

Bedi, B., N. M. Maurice, V. T. Ciavatta, K. S. Lynn, Z. Yuan, S. A. Molina, M. Joo, W. R. Tyor, J. B. Goldberg, M. Koval, C. M. Hart, and R. T. Sadikot – The FASEB JournalPubMed: PMID: 28442545.


Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection.

Limoli, D. H., G. B. Whitfield, T. Kitao, M. L. Ivey, M. R. Davis Jr, N. Grahl, D. A. Hogan, L. G. Rahme, P. L. Howell, G. A. O’Toole, J. B. Goldberg – mBioPubMed: PMID: 28325763.


Inhibition of Pseudomonas aeruginosa by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers.

Howard, J. J., C. R. Sturge, D. A. Moustafa, S. M. Daly, K. R. Marshall-Batty, C. F. Felder, D. Zamora, M. Yabe-Gill, M. Labandeira-Rey, S. M. Bailey, M. Wong, J. B. Goldberg, B. L. Geller, D. E. Greenberg – Antimicrobial Agents and Chemotherapy. PubMed: PMID: 28137807. 

Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa.

Floyd, M., M. Winn, C. Cullen, P. Sil, B. Chassaing, D. G. Yoo, A. T. Gewirtz, J. B. Goldberg, L. L. McCarter, B. Rada – PLOS Pathogens. PubMed: PMID: 27855208.


The Escherichia coli rhaSR-PrhaBAD Inducible Promoter System Allows Tightly Controlled Gene Expression over a Wide Range in Pseudomonas aeruginosa.

Meisner, J., J. B. Goldberg – Applied and Environmental MicrobiologyPubMed: PMID: 27613678.


Surfactant Protein A Recognizes Outer Membrane Protein OprH on Pseudomonas aeruginosa Isolates From Individuals With Chronic Infection.

Qadi, M., C. Lopez-Causapé, S. Izquierdo-Rabassa, M. Mateu Borrás, J. B. Goldberg, A. Oliver, S. Albertí – The Journal of Infectious DiseasesPubMed: PMID: 27543671.


Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori.

Owings, J. P., N. N. McNair, Y. F. Mui, T. N. Gustafsson, A. Holmgren, M. Contel, J. B. Goldberg, J. R. Mead – FEMS Microbiology Letters. PubMed: PMID: 27279627.


Enhanced Clearance of Pseudomonas aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma.

Bedi, B., Z. Yuan, M. Joo, S. M. Zughaier, J. B. Goldberg, J. L. Arbiser, C. M. Hart, R. T. Sadikot – Infection and ImmunityPubMed: PMID: 27091928.


Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.

Owings, J. P., E. G. Kuiper, S. M. Prezioso, J. Meisner, J. J. Varga, N. Zelinskaya, E. B. Dammer, D. M. Duong, N. T. Seyfried, S. Albertí, G. L. Conn, J. B. Goldberg – The Journal of Biological ChemistryPubMed: PMID: 26677219.

Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains.

Varga, J. J., M. Barbier, X. Mulet, P. Bielecki, J. A. Bartell, J. P. Owings, I. Martinez-Ramos, L. E. Hittle, M. R. Davis Jr., F. H. Damron, G. W. Liechti, J. Puchałka, V. A. dos Santos, R. K. Ernst, J. A. Papin, S. Albertí, A. Oliver, J. B. Goldberg – BMC GenomicsPubMed: PMID: 26519161.


Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders.

Moustafa, D. A., J. M. Scarff, P. P. Garcia, S. K. Cassidy, A. DiGiandomenico, D. M. Waag, T. J. Inzana, J. B. Goldberg – PLOS OnePubMed: PMID: 26148026.


Coevolution with bacteriophages drives genome-wide host evolution and constrains the acquisition of abiotic-beneficial mutations.

Scanlan, P. D., A. R. Hall, G. Blackshields, V. P. Friman, M. R. Davis Jr., J. B. Goldberg, A. Buckling – Molecular Biology and EvolutionPubMed: PMID: 25681383.


Single amino acid substitution in homogentisate 1,2-dioxygenase is responsible for pigmentation in a subset of Burkholderia cepacia complex isolates.

Gonyar, L. A., S. C. Fankhauser, J. B. Goldberg – Environmental Microbiology ReportsPubMed: PMID: 25294803.

Repurposing cryptosporidium inosine 5′-monophosphate dehydrogenase inhibitors as potential antibacterial agents.

Mandapati, K., S. K. Gorla, A. L. House, E. S. McKenney, M. Zhang, S. N. Rao, D. R. Gollapalli, B. J. Mann, J. B. Goldberg, G. D. Cuny, I. G. Glomski, L. Hedstrom – ACS Medicinal Chemistry LettersPubMed: PMID: 25147601.


From the environment to the host: re-wiring of the transcriptome of Pseudomonas aeruginosa from 22°C to 37°C.

Barbier, M., F. H. Damron, P. Bielecki, M. Suárez-Diez, J. Puchałka, S. Albertí, V. M. Dos Santos, J. B. Goldberg – PLOS OnePubMed: PMID: 24587139.


Vaccines for Pseudomonas aeruginosa: a long and winding road.

Priebe, G. P., J. B. Goldberg – Expert Review of VaccinesPubMed: PMID: 24575895.


Comparative metabolic systems analysis of pathogenic Burkholderia.

Bartell, J. A., P. Yen, J. J. Varga, J. B. Goldberg, J. A. Papin – Journal of BacteriologyPubMed: PMID: 24163337.