Research

Emory Mental Health and Development has been part of the North American Prodrome Longitudinal Studies (NAPLS) consortium.  The NAPLS sites collaborate on studies of the early indicators of risk for serious mental illness.  Drawing on increased scientific understanding of brain development during adolescence and early adulthood, investigators hope to identify factors that contribute to mental illness in adolescence and young adulthood. For more information about the NAPLS project, check the following website; http://napls.commons.yale.edu .

Some Recent Publications

Sleep and Psychosis

Goines, K. B., LoPilato, A. M., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Mathalon, D. H., McGlashan, T. H., Perkins, D. O., Tsuang, M. T., Woods, S. W., & Walker, E. F. (2019). Sleep problems and attenuated psychotic symptoms in youth at clinical high-risk for psychosis. Psychiatry Research, 282, 112492. https://doi.org/10.1016/j.psychres.2019.112492

Psychotropic Medication and Cortisol

Subramaniam, A., LoPilato, A., & Walker, E. F. (2019). Psychotropic medication effects on cortisol: Implications for research and mechanisms of drug action. Schizophrenia Research, 213, 6–14. https://doi.org/10.1016/j.schres.2019.06.023

Clinical and functional characteristics of youth at clinical high-risk for psychosis who do not transition to psychosis

Addington, J., Stowkowy, J., Liu, L., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Bearden, C. E., Mathalon, D. H., Santesteban-Echarri, O., & Woods, S. W. (2019). Clinical and functional characteristics of youth at clinical high-risk for psychosis who do not transition to psychosis. Psychological Medicine, 49(10), 1670–1677. https://doi.org/10.1017/S0033291718002258

Developmental mechanisms in the prodrome to psychosis

Walker, E. F., Trotman, H. D., Goulding, S. M., Holtzman, C. W., Ryan, A. T., McDonald, A., Shapiro, D. I., & Brasfield, J. L. (2013). Developmental mechanisms in the prodrome to psychosis. Development and Psychopathology, 25(4 Pt 2), 1585–1600. https://doi.org/10.1017/S0954579413000783

Stressor-Cortisol Concordance

Cullen, A. E., Addington, J., Bearden, C. E., Stone, W. S., Seidman, L. J., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Mathalon, D. H., McGlashan, T. H., Perkins, D. O., Tsuang, M. T., Woods, S. W., & Walker, E. F. (2020). Stressor-Cortisol Concordance Among Individuals at Clinical High-Risk for Psychosis: Novel Findings from the NAPLS Cohort. Psychoneuroendocrinology, 115, 104649. https://doi.org/10.1016/j.psyneuen.2020.104649

Schizophrenia: A Neural-Diathesis Stress Model

Walker, E. F., & Diforio, D. (1997). Schizophrenia: A neural diathesis-stress model. Psychological Review, 104(4), 667–685. https://doi.org/10.1037/0033-295x.104.4.667

Longitudinal changes in cortisol secretion and conversion to psychosis in at-risk youth

Walker, Elaine F., Brennan, P. A., Esterberg, M., Brasfield, J., Pearce, B., & Compton, M. T. (2010). Longitudinal changes in cortisol secretion and conversion to psychosis in at-risk youth. Journal of Abnormal Psychology, 119(2), 401–408. https://doi.org/10.1037/a0018399

Advances in the Neurobiology of Stress and Psychosis

Mittal, V. A., & Walker, E. F. (2019). Advances in the neurobiology of stress and psychosis. Schizophrenia Research, 213, 1–5. https://doi.org/10.1016/j.schres.2019.08.030