122. Catalytic asymmetric C–H activation by methyl thiophen-3-yldiazoacetate applied to the synthesis of (+)-cetiedil

Authors: Huw M.L Davies, Abbas M Walji, Robert J Townsend

Tetrahedron Lett., 

200243, 28, 4981-4983

1-s2.0-S0040403902009413-loc1

Dirhodium tetraprolinate catalyzed reaction of methyl thiophen-3-yldiazoacetate results in intermolecular allylic C–H activation by means of rhodium carbenoid induced C–H insertion. The reaction with 1,4-cyclohexadiene was applied to the asymmetric synthesis of (+)-cetiedil.

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