Authors: Huw M.L. Davies, Timothy M. Gregg
Tetrahedron Lett.,
2002, 43, 28, 4951-4953
The potent monoamine reuptake inhibitor (+)-indatraline, 1, was prepared in greater than 98% ee employing a highly enantioselective carbenoid C–H insertion reaction into 1,4-cyclohexadiene catalyzed by the chiral rhodium complex, Rh2(S-DOSP)4.