Authors: Huw M. L. Davies and Qihui Jin
J. Am. Chem. Soc.,
2004, 126 (35), 10862–10863
The Rh2(S-DOSP)4-catalyzed reaction of vinyldiazoacetates with dihydronaphthalenes results in a highly enantioselective (91−99.6% ee) and diastereoselective (>98% de) C−H functionalization. The apparent intermolecular C−H insertion was demonstrated to be a combined C−H activation/Cope rearrangement followed by a retro-Cope rearrangement.