Authors: James R. Manning, Huw M.L. Davies
Tetrahedron,
2008, 64, 29, 6901-6908
Studies related to the total synthesis of elisabethin C led to the discovery of a rhodium-catalyzed cascade sequence involving isoxazole ring expansion and a [4+3] cycloaddition. The scope of the isoxazole ring expansion was explored, resulting in the synthesis of a range of 2H-1,3-oxazines in 47–96% yield.