193. Efficient route to 2H-1,3-oxazines through ring expansion of isoxazoles by rhodium carbenoids

Authors: James R. Manning, Huw M.L. Davies


20086429, 6901-6908

Studies related to the total synthesis of elisabethin C led to the discovery of a rhodium-catalyzed cascade sequence involving isoxazole ring expansion and a [4+3] cycloaddition. The scope of the isoxazole ring expansion was explored, resulting in the synthesis of a range of 2H-1,3-oxazines in 47–96% yield.

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