207. Solvent-free catalytic enantioselective C–C bond forming reactions with very high catalyst turnover numbers

Authors: Philip Pelphrey, Jørn Hansen and Huw M. L. Davies

Chem. Sci.,

2010, 1, 254-257


Rhodium(II)-catalyzed reactions of donor/acceptor carbenoids can be achieved with catalyst loadings as low as 6 × 10−7 mol equivalents when the reactions are conducted in the absence of solvent. ReactIR studies demonstrate that donor/acceptor carbenoids are ideal for achieving high catalyst turnover numbers due to the rapid reactions of their diazo precursors and the enhanced selectivity of this class of carbenoids.

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