Authors: Yajing Lian, Dr. Kenneth I. Hardcastle, Prof. Dr. Huw M. L. Davies
Angew. Chem. Int. Ed.
2011, 50, 40, 9370-9373
Diastereoselectivity in control: The synthetic utility of the C–H functionalization/Cope rearrangement reaction has been greatly expanded by the design of substrates that will react through a boat transition state instead of a chair transition state. The products are formed with the opposite diastereoselectivity as previously obtained (see scheme, ABSA= acetamidobenzenesulfonylazide).