Authors: Yajing Lian and Huw M. L. Davies
Org. Lett.,
2012, 14 (7), 1934–1937
Asymmetric functionalization of N-heterocycles by vinylcarbenoids in the presence of catalytic amounts of Rh2(S-biTISP)2 has been successfully developed. This bridged dirhodium catalyst not only selectively enforces the reaction to occur at the vinylogous position of the carbenoid but also affords high levels of asymmetric induction.