Homeostatic plasticity in living embryonic networks

Understanding the compensatory plasticity that is triggered following perturbations to SNA (e.g. following fetal exposure to GABAergic modulators) will be important in understanding and avoiding disorders of the developing nervous system.

Optogenetic multi-electrode approaches to homeostatic plasticity

Identifying the triggers and functional goals of these compensatory mechanisms will be crucial for understanding a network’s response to neural injury.

Mechanisms of spontaneous network activity in the developing spinal cord

By identifying the mechanisms that regulate SNA, we hope to better understand the maturation of spinal circuitry (excitability, synaptic strength, ionic gradients).