255: Mild Aminoacylation of Indoles and Pyrroles through Three-component Reaction with Ynol Ethers and Sulfonyl Azides

Authors: Joshua Alford and Huw M. L. Davies

J. Am. Chem. Soc.,

2014, 136 (29), pp 10266-10269

Highlighted in Organic Process Research and Development


Abstract Image

An effective method for aminoacylation of indoles and pyrroles has been achieved. The transformation involves a multicomponent one-pot cascade reaction between indoles or pyrroles, ynol ethers, and sulfonyl azides, creating four different bonds regioselectively through N-sulfonyltriazole intermediates. The oxo-tryptamines and oxo-pyrroloethanamines are generated in moderate to high yields under mild reaction conditions.

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