Congratulationsto Sabrina Chow, who has been selected as RSPH’s Outstanding APE Award finalists 2023! Sabrina will receive her certificate and attend the event “Posters on the Skybridge” from 12-1pm on Monday April 10, 2023, with Dean Fallin–please mark your calendar and be there to support her if you are available during that time!
Congratulations to Zhenjiang Li, who has been selected to receive the 2022 Air and Waste Management Association’s (A&WMA) scholarship for his abstract titled “Metabolome-wide Association Study of Prenatal Exposure to Ambient PM 2.5 with Pre and Early-term Births in the Atlanta African American Maternal-Child Cohort.”! This is another great achievement for Zhenjiang after winning the best US DOHaD student abstract in October.
Huge congratulations to Zhenjiang Li who won the Outstanding Trainee Abstract Award at the US DOHaD Annual Meeting for his work entitled “Metabolome-wide Association Study of Prenatal Exposure to Ambient PM2.5 with Pre- and Early-term Births in the Atlanta African American Maternal-Child Cohort “
Congratulations to Dr. Donghai Liang and Kaitlin Taibl who won the Outstanding ECHO Abstract at the US DOHaD Annual Meeting for the work entitled “Newborn Metabolomic Signatures of Maternal Serum Per- and Polyfluoroalkyl Substance Levels and Reduced Length of Gestation: A Prospective Analysis in the Atlanta African American Maternal-Child Cohort”.
Congratulations to Kaitlin Taibl who received an abstract award from the ISEE Student New Researcher Network. The award was for the work she conducted during her second research rotation with Dr. Stephanie Eick! She was only ONE OF TWO students from the North America Chapter to receive an award!
Congratulations to Susan Hoffman who received an amazing award from ISEE– the prestigious travel award from the Wartenberg Memorial Fund!
We have four publications this month in Environment International, Fertility and Sterility and Environmental Research. Congratulations to Dr Donghai Liang, Dr Robert Hood, Youran Tan and our alumni Rachel Tchen.
1. “Using follicular fluid metabolomics to investigate the association between air pollution and oocyte quality“—Higher exposure to NO2 during ovarian stimulation was associated with many metabolites and biologic pathways involved in endogenous vitamin metabolism, hormone synthesis, and oxidative stress that may mediate the observed associations with lower oocyte quality. Full text link
2. “Characterizing the follicular fluid metabolome: quantifying the correlation across follicles and differences with the serum metabolome“— They compared the variability in metabolomes between the serum and follicular fluid, as well as across 3 dominant follicles. Full text link
3. “Use of high-resolution metabolomics to assess the biological perturbations associated with maternal exposure to Bisphenol A and Bisphenol F among pregnant African American women.”—Exposure to BPA and BPF in pregnant women is associated with the perturbation of aromatic amino acid metabolism, xenobiotics metabolism, steroid biosynthesis, and other amino acid metabolism closely linked to stress responses, inflammation, neural development, reproduction, and weight regulation. Full text link
4. “Metabolome-wide association study of the relationship between chlorpyrifos exposure and first trimester serum metabolite levels in pregnant Thai farmworkers“—In this study, they measured a urinary chlorpyrifos metabolite and used high-resolution metabolomics (HRM) to identify biological perturbations associated with chlorpyrifos exposure among pregnant women in Thailand, who are disparately exposed to high levels of OP insecticides. Full text link
Check out a new publication of “Postnatal exposure to ambient air pollutants is associated with the composition of the infant gut microbiota at 6-months of age” by Dr.Donghai Liang and Dr.Jeremy A Sarnat. This study provides the first evidence of significant associations between exposure to ambient air pollution and the composition of the infant gut microbiota, which may have important implications for future infant health and development. Full text link
Congratulations to our member Dr. Donghai Liang, Zhenjiang Li and Ziyin Tang and our alumni Xiaoyue Zhang for their publication in Bioinformatics-“Metapone: a Bioconductor package for joint pathway testing for untargeted metabolomics data“.
They developed an innovative R/Bioconductor package: metabolic pathway testing with positive and negative mode data (metapone), which can perform two novel statistical tests that take matching uncertainty into consideration—(i) a weighted gene set enrichment analysis-type test and (ii) a permutation-based weighted hypergeometric test. The package is capable of combining positive- and negative-ion mode results in a single testing scheme. For comprehensiveness, the built-in pathways were manually curated from three sources: Kyoto Encyclopedia of Genes and Genomes, Mummichog and The Small Molecule Pathway Database. Full text link
Congratulations to our group member Zhenjiang Li, with Drs. Jeremy Sarnat and Donghai Liang, for publishing a paper in the journal of Environmental Science & Technology on the evaluation of the use of saliva metabolome as a surrogate of blood metabolome in assessing internal exposures to traffic-related air pollution (TRAP).
This study collected 167 pairs of saliva and plasma samples from a cohort of 53 college student participants and measured corresponding indoor and outdoor concentrations of six air pollutants for the dormitories where the students lived. Using high-resolution metabolomics, 25 biological pathways associated with TRAP were detected via saliva and accounted for 69% of those detected via plasma. Given the slightly higher feature reproducibility found in saliva, these findings provide some indication that the saliva metabolome offers a sensitive and practical alternative to blood for characterizing individual biological responses to environmental exposures.
Congratulations to our member Dr. Robert Hood, Dr. Donghai Liang and Ziyin Tang for their new publication in Environment Epidemiology–“Length of PM2.5 exposure and alternations in the serum metabolome among women undergoing infertility treatment.
This study identified serum metabolites and metabolic pathways uniquely associated with acute versus chronic PM2.5 exposure. And these different biologic pathways may help explain differences in disease states when investigating different lengths of PM2.5 exposure.
Check out our latest publication on Environmental Science & Technology–“The oxidative Potential of Fine Particulate Matter and Biological Perturbations in Human Plasma and Saliva Metabolome“, which used metabolomics to examine biological perturbations associated with particulate matter oxidative potential and explore the molecular mechanism underlying air pollution health impacts! Congratulations to our members Ziyin Tang, Zhenjiang Li and Dr. Donghai Liang! Full text link here.
They confirmed pathways/ metabolites directly associated with fine particulate matter oxidative potential, which were implications of perturbations in acute inflammation, nucleic acid damage and repair, and energy perturbation.