Featured pre-prints

Meyer-Baese L, Morrissette A, Wang Y, Le Chatelier B, Borden P, Keilholz S, Stanley G, Jaeger D (2022). Cortical networks relating to arousal are differentially coupled to neural activity and hemodynamics. doi: https://doi.org/10.1101/2022.12.01.518759

Featured peer-reviewed publications

Lu X, Wang Y, Liu Z, Gou Y, Jaeger D, and St-Pierre F (2023). Widefield imaging of rapid pan-cortical voltage dynamics with an indicator evolved for one-photon microscopy. Nat Commun. 2023 Oct 12;14(1):6423.

Takahashi N, Moberg S, Zolnik TA, Catanese J, Sachdev RNS, Larkum ME, and Jaeger D (2021). Thalamic input to motor cortex facilitates goal-directed action initiation. Curr Biol 31(18): 4148-4155.e4.

Catanese J and Jaeger D (2021). Premotor ramping of thalamic neuronal activity is modulated by nigral inputs and contributes to control the timing of action release. J Neurosci 41(9): 1878-91.

Sanders TH and Jaeger D (2016). Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice. Neurobiol Dis 95: 225-37.

Lobb CJ and Jaeger D (2015). Bursting activity of substantia nigra pars reticulata neurons in mouse parkinsonism in awake and anesthetized states. Neurobiol Dis 75: 177-185.

Heck DH, De Zeeuw CI, Jaeger D, Khodakhah K and Person AL (2013). The neuronal code(s) of the cerebellum. J Neurosci 33(45): 17603-17609.

Lobb CJ, Zaheer AK, Smith Y, and Jaeger D (2013). In vivo electrophysiology of nigral and thalamic neurons in alpha-synuclein-overexpressing mice highlights differences from toxin-based models of parkinsonism. J Neurophysiol 110(12): 2792-2805.

Jaeger D (2011). Review: Synaptic integration in the cerebellar nuclei–perspectives from dynamic clamp and computer simulation studies. Cerebellum 10(4): 659-66.

Jaeger D (2007). Pauses as neural code in the cerebellum. Neuron 54(1): 9-10.

Herz AVM, Gollisch, T, Machens, CK, and Jaeger, D (2006). Review: Modeling single-neuron dynamics and computations: A balance of detail and abstraction.  Science 314: 80-85.

Jaeger D (2003). No parallel fiber volleys in the cerebellar cortex: evidence from cross-correlation analysis between Purkinje cells in a computer model and in recordings from anesthetized rats. J Comput Neurosci 3: 311-27.

Stern E, Jaeger D, and Wilson CJ (1998). Membrane potential fluctuations of simultaneously recorded striatal spiny neurons in vivo. Nature 394: 475-478.

Jaeger D, Gilman S, and Aldridge JW (1990). A multiwire electrode for single unit recording in deep brain structures. J Neurosci Meth 32: 143-148.

Links to Complete Publication List

D. Jaeger Google Scholar Profile

D. Jaeger PubMed Publications

Publications Since 2015

Cavarretta F, Kahl T, Jaeger D. Intrinsic properties of neurons in motor thalamus and connected cortex. In Ursey W, Sherman S (eds), “The Cerebral Cortex and Thalamus” (New York; 2023; online edn, Oxford Acacdemic, 1 Nov. 2023) https://doi.org/10.1093/med/9780197676158.001.0001.

Cavarretta F, Jaeger D. Modeling Synaptic Integration of Bursty and β Oscillatory Inputs in Ventromedial Motor Thalamic Neurons in Normal and Parkinsonian States. eNeuro. 2023 Dec 12;10(12):ENEURO.0237-23.2023. doi: 10.1523/ENEURO.0237-23.2023. PMID: 37989589; PMCID: PMC10726287.

Ledderose JMT, Zolnik TA, Toumazou M, Trimbuch T, Rosenmund C, Eickholt BJ, Jaeger D, Larkum ME, Sachdev RNS. Layer 1 of somatosensory cortex: an important site for input to a tiny cortical compartment. Cereb Cortex. 2023 Nov 27;33(23):11354-11372. doi: 10.1093/cercor/bhad371. PMID: 37851709; PMCID: PMC10690867.

Lu X, Wang Y, Liu Z, Gou Y, Jaeger D, St-Pierre F. Widefield imaging of rapid pan-cortical voltage dynamics with an indicator evolved for one-photon microscopy. Nat Commun. 2023 Oct 12;14(1):6423. doi: 10.1038/s41467-023-41975-3. PMID: 37828037; PMCID: PMC10570354.

Prichard A, Garza KM, Shridhar A, He C, Bitarafan S, Pybus A, Wang Y, Snyder E, Goodson MC, Franklin TC, Jaeger D, Wood LB, Singer AC. Brain rhythms control microglial response and cytokine expression via NF-κB signaling. Sci Adv. 2023 Aug 9;9(32):eadf5672. doi: 10.1126/sciadv.adf5672. Epub 2023 Aug 9. PMID: 37556553; PMCID: PMC10411883.

Borden PY, Wright NC, Morrissette AE, Jaeger D, Haider B, Stanley GB. Thalamic bursting and the role of timing and synchrony in thalamocortical signaling in the awake mouse. Neuron. 2022 Jun 28:S0896-6273(22)00546-3. doi: 10.1016/j.neuron.2022.06.008. Epub ahead of print. PMID: 35803270.

Takahashi N, Moberg S, Zolnik TA, Catanese J, Sachdev RNS, Larkum ME, Jaeger D. Thalamic input to motor cortex facilitates goal-directed action initiation. Curr Biol. 2021 Sep 27;31(18):4148-4155.e4. doi: 10.1016/j.cub.2021.06.089. Epub 2021 Jul 23. PMID: 34302741; PMCID: PMC8478854.

Bichler EK, Cavarretta F, Jaeger D. Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice. eNeuro. 2021 Feb 24;8(1):ENEURO.0436-20.2021. doi: 10.1523/ENEURO.0436-20.2021. PMID: 33509950; PMCID: PMC7920540.

Catanese J, Jaeger D. Premotor Ramping of Thalamic Neuronal Activity Is Modulated by Nigral Inputs and Contributes to Control the Timing of Action Release. J Neurosci. 2021 Mar 3;41(9):1878-1891. doi: 10.1523/JNEUROSCI.1204-20.2020. Epub 2021 Jan 14. PMID: 33446518; PMCID: PMC7939094.

Abbasi S, Maran S, Jaeger D. A general method to generate artificial spike train populations matching recorded neurons. J Comput Neurosci. 2020 Feb;48(1):47-63. doi: 10.1007/s10827-020-00741-w. Epub 2020 Jan 23. PMID: 31974719; PMCID: PMC7036336.

Morrissette AE, Chen PH, Bhamani C, Borden PY, Waiblinger C, Stanley GB, Jaeger D. Unilateral Optogenetic Inhibition and Excitation of Basal Ganglia Output Affect Directional Lick Choices and Movement Initiation in Mice. Neuroscience. 2019 Dec 15;423:55-65. doi: 10.1016/j.neuroscience.2019.10.031. Epub 2019 Nov 6. PMID: 31705892; PMCID: PMC6917693.

Cao Y, Liu Y, Jaeger D, Heck DH. Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations. Front Neural Circuits. 2017 Sep 20;11:67. doi: 10.3389/fncir.2017.00067. PMID: 28979195; PMCID: PMC5611370.

Abbasi S, Hudson AE, Maran SK, Cao Y, Abbasi A, Heck DH, Jaeger D. Robust transmission of rate coding in the inhibitory Purkinje cell to cerebellar nuclei pathway in awake mice. PLoS Comput Biol. 2017 Jun 15;13(6):e1005578. doi: 10.1371/journal.pcbi.1005578. PMID: 28617798; PMCID: PMC5491311.

Borden PY, Ortiz AD, Waiblinger C, Sederberg AJ, Morrissette AE, Forest CR, Jaeger D, Stanley GB. Genetically expressed voltage sensor ArcLight for imaging large scale cortical activity in the anesthetized and awake mouse. Neurophotonics. 2017 Jul;4(3):031212. doi: 10.1117/1.NPh.4.3.031212. Epub 2017 May 4. Erratum in: Neurophotonics. 2017 Jul;4(3):039801. PMID: 28491905; PMCID: PMC5416966.

Sreenivasan V, Kyriakatos A, Mateo C, Jaeger D, Petersen CC. Parallel pathways from whisker and visual sensory cortices to distinct frontal regions of mouse neocortex. Neurophotonics. 2017 Jul;4(3):031203. Epub 2016 Nov 23. PubMed PMID: 27921067; PubMed Central PMCID: PMC5120210.

Lang EJ, Apps R, Bengtsson F, Cerminara NL, De Zeeuw CI, Ebner TJ, Heck DH, Jaeger D, Jörntell H, Kawato M, Otis TS, Ozyildirim O, Popa LS, Reeves AM, Schweighofer N, Sugihara I, Xiao J. The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper. Cerebellum. 2017 Feb;16(1):230-252. doi: 10.1007/s12311-016-0787-8. PubMed PMID: 27193702; PubMed Central PMCID: PMC5116294.

Sanders TH, Jaeger D. Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice. Neurobiol Dis. 2016 Nov;95:225-37. doi: 10.1016/j.nbd.2016.07.021. Epub 2016 Jul 21. PubMed PMID: 27452483; PubMed Central PMCID: PMC5010926.

Lu H, Yang B, Jaeger D. Cerebellar Nuclei Neurons Show Only Small Excitatory Responses to Optogenetic Olivary Stimulation in Transgenic Mice: In Vivo and InVitro Studies. Front Neural Circuits. 2016 Mar 24;10:21. doi:10.3389/fncir.2016.00021. eCollection 2016. PubMed PMID: 27047344; PubMed Central PMCID: PMC4805604.

Kita H, Jaeger D.  Organization of the Globus Pallidus. In: Steiner H, Tseng K (eds) Handbook of Behavioral Neuroscience, Elsevier, vol 24, 2016, pp 259–276.

Jaeger D, Lu H.  Cerebellar Nuclei.  In: Gruol et al. (eds) Essentials of Cerebellum and Cerebellar Disorders, Springer, 2016, pp 311-315.

Lobb CJ, Jaeger D. Bursting activity of substantia nigra pars reticulata neurons in mouse parkinsonism in awake and anesthetized states. Neurobiol Dis. 2015 Mar;75:177-85. doi: 10.1016/j.nbd.2014.12.026. Epub 2015 Jan 6. PMID: 25576395; PMCID: PMC4406485.

Jaeger D, Jung R (eds) Encyclopedia of Computational Neuroscience.  Springer, 2015.

COVER:  Neuroscientists increasingly rely on the use of computers and simulations, because the systems they are studying are usually too complex for all of the data to be collected. It is thus a challenge to focus on the conceptually relevant parameters rather than simply trying to model reality by adding more and more details. Image: Kelly Buckheit Krause (Photos: Rob Melnychu/Getty; Matthias Kulka/Corbis)32, pp. 143-148.