Publications

Featured Publications

Jaeger D., Gilman S., and Aldridge J.W. (1990) A multiwire electrode for single unit recording in deep brain structures. J. Neurosci. Meth., Vol 32, pp. 143-148.

Stern E., Jaeger D., Wilson C.J. (1998) Membrane potential fluctuations of simultaneously recorded striatal spiny neurons in vivo. Nature. 394:475-478. 

Jaeger D. (2003) No parallel fiber volleys in the cerebellar cortex: evidence from cross-correlation analysis between Purkinje cells in a computer model and in recordings from anesthetized rats. J Comput Neurosci. (3):311-27.

Herz, A.V.M, Gollisch, T., Machens, C.K., and Jaeger, D. (2006) Review: Modeling single-neuron dynamics and computations: A balance of detail and abstraction.  Science. 314: 80-85. 

Jaeger D. (2007) Pauses as neural code in the cerebellum. Neuron. 54(1):9-10. 

Jaeger D. (2011) Review : Synaptic integration in the cerebellar nuclei–perspectives from dynamic clamp and computer simulation studies. Cerebellum. 10(4):659-66. Review. 

Lobb, C. J., A. K. Zaheer, Y. Smith and D. Jaeger (2013). “In vivo electrophysiology of nigral and thalamic neurons in alpha-synuclein-overexpressing mice highlights differences from toxin-based models of parkinsonism.” J Neurophysiol 110(12): 2792-2805.

Heck, D. H., C. I. De Zeeuw, D. Jaeger, K. Khodakhah and A. L. Person (2013). “The neuronal code(s) of the cerebellum.” J Neurosci 33(45): 17603-17609.

Edgerton, J. R. and D. Jaeger (2014). “Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation.” Front Cell Neurosci 8: 36.

Lobb, C. J. and D. Jaeger (2015). “Bursting activity of substantia nigra pars reticulata neurons in mouse parkinsonism in awake and anesthetized states.” Neurobiol Dis 75: 177-185.  

Sanders TH, Jaeger D. (2016) Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice. Neurobiol Dis.;95:225-37. 

 

Link to Complete Publication List

D. Jaeger PubMed Publications

 

Publications Since 2002: 

Sreenivasan V, Kyriakatos A, Mateo C, Jaeger D, Petersen CC. Parallel pathways  from whisker and visual sensory cortices to distinct frontal regions of mouse neocortex. Neurophotonics. 2017 Jul;4(3):031203. Epub 2016 Nov 23. PubMed PMID: 27921067; PubMed Central PMCID: PMC5120210.

Lang EJ, Apps R, Bengtsson F, Cerminara NL, De Zeeuw CI, Ebner TJ, Heck DH, Jaeger D, Jörntell H, Kawato M, Otis TS, Ozyildirim O, Popa LS, Reeves AM, Schweighofer N, Sugihara I, Xiao J. The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper. Cerebellum. 2017 Feb;16(1):230-252. doi: 10.1007/s12311-016-0787-8. PubMed PMID: 27193702; PubMed Central PMCID: PMC5116294.

Sanders TH, Jaeger D. Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice. Neurobiol Dis. 2016 Nov;95:225-37. doi: 10.1016/j.nbd.2016.07.021. Epub 2016 Jul 21. PubMed PMID: 27452483; PubMed Central PMCID: PMC5010926.

Lu H, Yang B, Jaeger D. Cerebellar Nuclei Neurons Show Only Small Excitatory Responses to Optogenetic Olivary Stimulation in Transgenic Mice: In Vivo and InVitro Studies. Front Neural Circuits. 2016 Mar 24;10:21. doi:10.3389/fncir.2016.00021. eCollection 2016. PubMed PMID: 27047344; PubMed Central PMCID: PMC4805604.

Thompson GJ, Pan WJ, Billings JC, Grooms JK, Shakil S, Jaeger D, Keilholz SD. Phase-amplitude coupling and infraslow (<1 Hz) frequencies in the rat brain: relationship to resting state fMRI. Front Integr Neurosci. 2014 May 27;8:41. doi: 10.3389/fnint.2014.00041. eCollection 2014. PubMed PMID: 24904325; PubMed Central PMCID: PMC4034045.

Edgerton JR, Jaeger D. Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation. Front Cell Neurosci. 2014 Feb 11;8:36. doi: 10.3389/fncel.2014.00036. eCollection 2014. PubMed PMID: 24574972; PubMed Central PMCID: PMC3920182.

Thompson GJ, Pan WJ, Magnuson ME, Jaeger D, Keilholz SD. Quasi-periodic patterns (QPP): large-scale dynamics in resting state fMRI that correlate with local infraslow electrical activity. Neuroimage. 2014 Jan 1;84:1018-31. doi: 10.1016/j.neuroimage.2013.09.029. Epub 2013 Sep 23. PubMed PMID: 24071524; PubMed Central PMCID: PMC3869452.

Thompson GJ, Merritt MD, Pan WJ, Magnuson ME, Grooms JK, Jaeger D, Keilholz SD. Neural correlates of time-varying functional connectivity in the rat. Neuroimage. 2013 Dec;83:826-36. doi: 10.1016/j.neuroimage.2013.07.036. Epub 2013 Jul 19. PubMed PMID: 23876248; PubMed Central PMCID: PMC3815981.

Heck DH, De Zeeuw CI, Jaeger D, Khodakhah K, Person AL. The neuronal code(s) of the cerebellum. J Neurosci. 2013 Nov 6;33(45):17603-9. doi: 10.1523/JNEUROSCI.2759-13.2013. Review. PubMed PMID: 24198351; PubMed Central PMCID: PMC3818542.

Jaeger D, Jorntell H, Kawato M. Computation in the cerebellum. Neural Netw. 2013 Nov;47:1-2. doi: 10.1016/j.neunet.2013.08.003. PubMed PMID: 24041235. \

Steuber V, Jaeger D. Modeling the generation of output by the cerebellar nuclei. Neural Netw. 2013 Nov;47:112-9. doi: 10.1016/j.neunet.2012.11.006. Epub 2012 Nov 21. Review. PubMed PMID: 23200193; PubMed Central PMCID: PMC3596440. 

Feng SS, Lin R, Gauck V, Jaeger D. Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance. Cerebellum. 2013 Oct;12(5):692-706. doi: 10.1007/s12311-013-0476-9. PubMed PMID: 23605187; PubMed Central PMCID: PMC3762888.

Pan WJ, Thompson GJ, Magnuson ME, Jaeger D, Keilholz S. Infraslow LFP correlates to resting-state fMRI BOLD signals. Neuroimage. 2013 Jul 1;74:288-97. doi: 10.1016/j.neuroimage.2013.02.035. Epub 2013 Feb 26. PubMed PMID: 23481462; PubMed Central PMCID: PMC3615090.

Cao Y, Maran SK, Dhamala M, Jaeger D, Heck DH. Behavior-related pauses in simple-spike activity of mouse Purkinje cells are linked to spike rate modulation. J Neurosci. 2012 Jun 20;32(25):8678-85. doi: 10.1523/JNEUROSCI.4969-11.2012. PubMed PMID: 22723707; PubMed Central PMCID: PMC3403286.

Jaeger D. Mini-review: synaptic integration in the cerebellar nuclei–perspectives from dynamic clamp and computer simulation studies. Cerebellum. 2011 Dec;10(4):659-66. doi: 10.1007/s12311-011-0248-3. Review. PubMed PMID: 21259124.

Hendrickson EB, Edgerton JR, Jaeger D. The use of automated parameter searches to improve ion channel kinetics for neural modeling. J Comput Neurosci. 2011 Oct;31(2):329-46. doi: 10.1007/s10827-010-0312-x. Epub 2011 Jan 18. PubMed PMID: 21243419.

Edgerton JR, Jaeger D. Dendritic sodium channels promote active decorrelation and reduce phase locking to parkinsonian input oscillations in model globus pallidus neurons. J Neurosci. 2011 Jul 27;31(30):10919-36. doi: 10.1523/JNEUROSCI.6062-10.2011. PubMed PMID: 21795543; PubMed Central PMCID: PMC3178657.

Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D. Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. J Comput Neurosci. 2011 Jun;30(3):633-58. doi: 10.1007/s10827-010-0282-z. Epub 2010 Nov 4. PubMed PMID: 21052805; PubMed Central PMCID: PMC3108018.

Lin RJ, Jaeger D. Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources. J Neurophysiol. 2011 May;105(5):2610-24. doi: 10.1152/jn.00968.2010. Epub 2011 Feb 16. Erratum in: J Neurophysiol. 2012 Aug;108(4):1223-4. PubMed PMID: 21325676; PubMed Central PMCID: PMC3094164. 

Hendrickson EB, Edgerton JR, Jaeger D. The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites. J Comput Neurosci. 2011 Apr;30(2):301-21. doi: 10.1007/s10827-010-0258-z. Epub 2010 Jul 10. PubMed PMID: 20623167; PubMed Central PMCID: PMC3058356.

Pan WJ, Thompson G, Magnuson M, Majeed W, Jaeger D, Keilholz S. Broadband local field potentials correlate with spontaneous fluctuations in functional magnetic resonance imaging signals in the rat somatosensory cortex under isoflurane anesthesia. Brain Connect. 2011;1(2):119-31. doi: 10.1089/brain.2011.0014. PubMed PMID: 22433008; PubMed Central PMCID: PMC3621847.

Edgerton JR, Hanson JE, Günay C, Jaeger D. Dendritic sodium channels regulate network integration in globus pallidus neurons: a modeling study. J Neurosci. 2010 Nov 10;30(45):15146-59. doi: 10.1523/JNEUROSCI.2662-10.2010. PubMed PMID: 21068320; PubMed Central PMCID: PMC3022226.

Sangrey T, Jaeger D. Analysis of distinct short and prolonged components in rebound spiking of deep cerebellar nucleus neurons. Eur J Neurosci. 2010 Nov;32(10):1646-57. doi: 10.1111/j.1460-9568.2010.07408.x. Epub 2010 Oct 8. PubMed PMID: 21039958; PubMed Central PMCID: PMC3058674.

Pan WJ, Thompson G, Magnuson M, Majeed W, Jaeger D, Keilholz S. Simultaneous FMRI and electrophysiology in the rodent brain. J Vis Exp. 2010 Aug 19;(42). pii: 1901. doi: 10.3791/1901. PubMed PMID: 20811324; PubMed Central PMCID: PMC3156003.

Schultheiss NW, Edgerton JR, Jaeger D. Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. J Neurosci. 2010 Feb 17;30(7):2767-82. doi: 10.1523/JNEUROSCI.3959-09.2010. PubMed PMID: 20164360; PubMed Central PMCID: PMC2833015.

Günay C, Edgerton JR, Li S, Sangrey T, Prinz AA, Jaeger D. Database analysis of simulated and recorded electrophysiological datasets with PANDORA’s toolbox. Neuroinformatics. 2009 Jun;7(2):93-111. doi: 10.1007/s12021-009-9048-z. Epub 2009 May 28. PubMed PMID: 19475520; PubMed Central PMCID: PMC2786174.

Günay C, Edgerton JR, Jaeger D. Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. J Neurosci. 2008 Jul 23;28(30):7476-91. doi: 10.1523/JNEUROSCI.4198-07.2008. PubMed PMID: 18650326.

Rowland NC, Jaeger D. Responses to tactile stimulation in deep cerebellar nucleus neurons result from recurrent activation in multiple pathways. J Neurophysiol. 2008 Feb;99(2):704-17. Epub 2007 Dec 12. PubMed PMID: 18077662. 

Feng SS, Jaeger D. The role of SK calcium-dependent potassium currents in regulating the activity of deep cerebellar nucleus neurons: a dynamic clamp study. Cerebellum. 2008;7(4):542-6. doi: 10.1007/s12311-008-0077-1. PubMed PMID: 18985424.

Jaeger D. Pauses as neural code in the cerebellum. Neuron. 2007 Apr 5;54(1):9-10. PubMed PMID: 17408572.

Herz AV, Gollisch T, Machens CK, Jaeger D. Modeling single-neuron dynamics and computations: a balance of detail and abstraction. Science. 2006 Oct 6;314(5796):80-5. Review. PubMed PMID: 17023649.

Rowland NC, Jaeger D. Coding of tactile response properties in the rat deep cerebellar nuclei. J Neurophysiol. 2005 Aug;94(2):1236-51. PubMed PMID: 16061491.

Hanson JE, Smith Y, Jaeger D. Sodium channels and dendritic spike initiation at excitatory synapses in globus pallidus neurons. J Neurosci. 2004 Jan 14;24(2):329-40. PubMed PMID: 14724231.

Kreiner L, Jaeger D. Synaptic shunting by a baseline of synaptic conductances  modulates responses to inhibitory input volleys in cerebellar Purkinje cells. Cerebellum. 2004;3(2):112-25. PubMed PMID: 15233579.

Goldberg JA, Kats SS, Jaeger D. Globus pallidus discharge is coincident with striatal activity during global slow wave activity in the rat. J Neurosci. 2003 Nov 5;23(31):10058-63. PubMed PMID: 14602820.

Gauck V, Jaeger D. The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei. J Neurosci. 2003 Sep 3;23(22):8109-18. PubMed PMID: 12954873.

Kotter E, Roesner A, Torsten Winterer J, Ghanem N, Einert A, Jaeger D, Uhrmeister P, Langer M. Evaluation of Lossy data compression of chest X-rays: a receiver operating characteristic study. Invest Radiol. 2003 May;38(5):243-9. PubMed PMID: 12750612.

Jaeger D. No parallel fiber volleys in the cerebellar cortex: evidence from cross-correlation analysis between Purkinje cells in a computer model and in recordings from anesthetized rats. J Comput Neurosci. 2003 May-Jun;14(3):311-27. PubMed PMID: 12766430.

Hanson JE, Jaeger D. Short-term plasticity shapes the response to simulated normal and parkinsonian input patterns in the globus pallidus. J Neurosci. 2002 Jun 15;22(12):5164-72. PubMed PMID: 12077211.

 

 

COVER:  Neuroscientists increasingly rely on the use of computers and simulations, because the systems they are studying are usually too complex for all of the data to be collected. It is thus a challenge to focus on the conceptually relevant parameters rather than simply trying to model reality by adding more and more details. Image: Kelly Buckheit Krause (Photos: Rob Melnychu/Getty; Matthias Kulka/Corbis)32, pp. 143-148.