NBB in Paris

Dear friend,

I’m back! So, yesterday I got up bright and early to go see the infamous Catacombs that lurk beneath Paris. My friends and I arrived at Denfert-Rochereau just one stop away from Cité with ten minutes to spare before the attraction opened up. As we disembarked from the Métro stop, we were greeted by a huge horde of people, but little did we know how long we would actually have to wait. Despite mentally preparing ourselves to wait in line for a bit, we overheard whispers around us about a three-hour long wait! However, this was the only time we had to explore the Catacombs, so we decided to forego the option of going elsewhere, and instead take the risk and wait in line. And boy, it was like waiting in the queue for a Disneyland ride all over again. People weren’t lying – we didn’t enter the Catacombs until over three hours later!

Look at all those people!

So, was the grueling three-hour long queue worth the wait? Besides getting in for free, courtesy of Accent, it definitely was! We had such a blast walking around the Catacombs that the feeling was almost surreal and hard to believe that a place like this actually existed.

Making our way to the heart of the Catacombs.

The Catacombs wasn’t the only place with these crazy lines. I experienced similar situations at the Louvre and Versailles. For the Louvre, we were able to find a “secret” entrance and only had to wait for half an hour. However, for Versailles, we had to leave Cité at 7:15 in the morning in an attempt to beat the crowds, but even with that we were swept into the crowds. In both cases, the rewards of seeing the places and being able to enjoy them made the wait worthwhile.

In front of my favorite painting at the Louvre.

When I got back to my room at Cité, I delved into some research to find out more about waiting in lines and why we do endure long waits. In a recent article in Psychology Today, Psychologist Adrian Furnham notes that people who spend hours waiting in line often get restless because they expect instant gratification in what they are waiting for. In addition, people who study such waiting behavior have reported that uncertainty makes the wait feel longer and increases anxiety, but distractions can often make wait feel shorter. Furnham urges that we should appreciate and accept waiting, for the rewards that follow outweigh the sacrifices.

Location of the PFC in the brain.

Such an event is characterized as the concept known as delayed gratification. I decided to research some more, and found that in delayed gratification the individual chooses the greater reward with a time delay over immediate gratification because the outcome is worth more (Karniol et al., 2011). Also, the prefrontal cortex (PFC) plays a major role in delayed gratification, a brain structure important for decision-making (Churchwell et al., 2009).

What specific brain areas are activated in varied gratification responses? After researching more on this topic, I found a particular study that focused on the brain areas involved in immediate and delayed gratification (Wang et al., 2014). In this study, the recruited participants were placed in a functional magnetic resonance imaging (fMRI) scanner and were asked to choose either an immediate reward or a delayed reward. The researchers then analyzed these results to determine which brain areas were involved in the process.

So what did the researchers find? Well, to begin with, they found that subjects responded more to the delayed reward when the reward increased in amount. Specifically, this study revealed that dorsal medial prefrontal cortex (DmPFC) was activated during immediate rewards. On the other hand, the anterior DmPFC was activated under delayed gratification. In addition, the researchers found that decision making activated the nucleus accumbens (NAcc), a brain structure that mediates reward systems and processes. Therefore, individuals who valued their choices had activation of the NAcc. From these findings, the researchers concluded that immediate and delayed rewards are activated in different parts of the DmPFC, though it would be nice to see further research to see how activation of the NAcc varied in both circumstances.

Gardens at Versailles!

In the end, this study shines some light onto which areas of the brain are activated under delayed gratification. This means that while I was waiting in line to go to the Catacombs, other than my fear of walking through the empire of the dead, my anterior DmPFC was activated more because I had waited for so long and finally was rewarded by entering the place.

After completed my visit to the Catacombs, I headed to my favorite gelato shop, Amorino. Once again, I was greeted with yet another long line, but waiting was totally worth it, especially when I get rewarded with this cool and delicious treat!

Sincerely,

Kaavya

References:

Churchwell JC, Morris AM, Heurtelou NM, Kesner RP (2009) Interactions Between the Prefrontal Cortex and Amygdala During Delay Discounting and Reversal. Behavioral Neuroscience 123(6): 1185-1196.

Furnham A (2014) The Psychology of Waiting. Psychology Today.

Karniol R, Galili L, Shtilerman D, Naim R, Stern K, Manjoch H, Silverman R (2011) Why Superman Can Wait: Cognitive Self-Transformation in the Delay of Gratification Paradigm. Journal of Clinical Child and Adolescent Psychology 40(20): 307-317.

Wang Q, Luo S, Monterosso J, Zhang J, Fang X, Dong Q, Xue G (2014) Distributed Value Representation in the Medial Prefrontal Cortex during Intertemporal Choices. The Journal of Neuroscience 34(22): 7522-7530.

Image of PFC: http://connersclinic.com/wp-content/uploads/2015/03/prefrontal_cortex.jpg

It was in the days before coming to Paris, I was beginning the preparations of packing up my clothes for my trip. I had recently grown an affinity towards colored pants. They are just so great! Blue ones, red ones, pink ones, green ones! So many colors and so many ways to wear them! You just pair them with some neutrals, or other bright colors, and you have an outfit ready to go! I was especially excited to bring them to Paris because my mom had just gotten me a couple of new pairs, coral and blue-green.

What I want to be wearing all the time…

Unfortunately (or perhaps fortunately), as I was laying out my clothes to pack, my mom asked “Are you sure you want to take those? They don’t really wear colored pants over there.”

“But mom… they are my favorite… It doesn’t really matter all that much.”

“I don’t know Kayleigh, the guide says that you should try to fit. That way you won’t be a target and they will be friendlier to you.”

“So what color clothing should I wear then?”

“Black… and sometimes very, very dark gray.”

Okay so she didn’t actually say that last line, it’s actually a line from The Lego Movie (great movie by the way!). But what she said did have some merit to it. When you look like the group members and act like the group members, then usually they accept you more, right?

Old Woman, Young Lady Illusion from Pinterest

An article written by Stallen et al. addresses the neurology behind this desire to fit in and be part of a group. The experiment was designed to look at in-group influence, taking the tastes of others to show that you belong to a specific group. The researchers took 24 healthy, right-handed individuals (12 female, 12 male) and upon arrival to the testing site showed them 5 perceptual illusions. (You’ve probably seen this type of image before. These are images like the young-girl old-woman picture). The participants then had to choose which image they saw, either the old-woman or young-girl. Based on their answer they were then rated as either a foreground perceiver or a background perceiver. However, these terms meant absolutely nothing, because everyone was put into the foreground perceiver group. This was done to make sure that they had groups without the occurrence of bias.

Experimental Design from Stallen et al.

Anyways, the participants were then put into the fMRI machine and the real decision making experiment began. The participants looked at a screen, and on the screen a flash of dots would appear briefly. The number could be as little as 5 dots (easy) or as many at 30 dots (hard). After the participants saw the dots, they estimated the number they thought that they saw in their heads. Now this is where it gets tricky (literally and figuratively!). In order to mislead the participants into in-group thinking, a computer generated answer was shown on the screen from either an “in-group” member, an “out-group” member or an unclassified member. Now keep in mind that these “answers” were computer generated, none of them actually came from another person, but the participant thought that they did.

After the flash of the fake guesses, the participant had to insert his/her choice of how many dots there were into the machine. At the end, they were asked a series of questions about their connection, trust, and positivity towards the different groups, the in-group, out-group and unclassified.

Brain Images from Stallen et al.

Overall, the results showed increased activity of the right caudate subgenual anterior cingulate cortex, right hippocampus and the intersection of the right posterior insula and the posterior superior temporal sulcus in in-group members. Now, I know what you all are thinking… I know exactly what those regions do, and I completely understand the relationship between them and in-group mentality. But just to make sure that I understand it, I’ll explain it to you. You know, just to make sure I get it.

Me fitting in… literally and figuratively. Photo Credit to Kimi Chan.

Activation of these areas led to more positive associations and greater trust with in-group members than out-group or unclassified members. When shown fake responses from out-group or unclassified members, the participants were less likely tocopy the answers as compared to the in-group responses. In general, people tend to have a positive experience with social inclusion and acceptance, and so, in turn, in-group members receive a positive effect and reward from being included.

This article was really great because it not only showed the behavioral aspects of in-group thinking, but the neurological aspects as well. It led me to pose the question as to why I was so afraid of standing out, besides the fact that it would make pickpockets easier to target me. I adjusted my whole wardrobe to include things that I never usually wear, just so I could blend in a bit more. It’s all about that group mentality man.. FIGHT THE POWER!

… What I’m actually wearing all the time. Cute, but not summer wear… it needs more color 🙁

However, in all seriousness, it’s nice that I brought clothes to fit in. It’s nice not to be immediately identified as a foreigner. That is until I open my mouth, then it’s all downhill from there (please refer to my previous blog post). But for the most part I tend to fit in as Parisian, people talk to me in French, as me directions in French, ask for help with the turnstiles in the subway in French… I think I did too much of a good job at blending in. But as they say, when in Rome, do as the Romans do! Or shall I say, when in Paris, dress and the Parisians do!

Stallen, M., Smidts, A., & Sanfey, A. G. (2013). Peer influence: neural            mechanisms underlying in-group conformity. Frontiers in Human Neuroscience, 7.     http://doi.org/10.3389/fnhum.2013.00050

Batman was from Pinterest. The caption ruined the picture.

Now that the end of my time in Paris is right around the corner, I have realized that I would no longer be able to enjoy the beautiful and mouthwatering pastries that are sold all over the city.

Ohh beautiful pastries…my heart will truly miss you all when I leave Paris.

Even if I stayed here for a longer period of time, I don’t think that I would ever say that I have had enough of the French pastries since I fell in love with them from day one (French food is great too, but I LOVEEE the pastries!!!). After reflecting on all the beautiful foods (mainly pastries) that I have tried with the aims of getting a last bite of the most delicious ones before I depart, I began to wonder about the way in which their pleasant appearance is reflected in my brain.

Selfie before eating my first French chocolate macaroon!

I have always liked to try different foods, yet there have been times when I have found myself disliking some based on their appearance (I know that we should not judge a book by its cover, but for the eyes of my stomach that is an important feature).

Based on all my experiences about pleasant and unpleasant appearance of foods,  I decided to look into the literature of neuroscience to learn if  food appearance had any impact on brain activity.  I came across an interesting study on the activation of the orbitofrontal cortex (OFC) and the ventral pallidum (VP) from the presentation of food items to human participants. These areas were particularly studied since previous research observed their activation during food reward studies on animals like mice and monkeys (Smith et al., 2005; Izquierdo et al., 2004). You can see their location in the brain in the images below .

Schematic of the location of the ventral pallidum (VP) within the basal ganglia

Location of the OFC

The study I found, conducted by Simmons et al. (2014), looked for the activation of the OFC and VP through fMRI imaging testing, where a machine scans and records brain activity by detecting changes in blood flow,  of 22 participants while they completed a task (described below). The participants were all right-handed, native English-speaking healthy volunteers (12 males and 10 females between the ages of 21-39). The task that they completed while undergoing the fMRI scan consisted of  rating the pleasantness of 144 food images that were presented on a screen inside the scanner. The rating was based on the question they were asked: “If given the opportunity right now, how pleasant would it be to eat this food?”

The way in which the participants provided their responses was by using a scroll wheel (similar to a regular computer mouse) to select the values outlined in a scale presented next to each of the food images. The participants were presented with a total of 144 high-resolution photographs of a variety of foods (from highly processed to natural fruits and vegetables) for 5 seconds each. In between each image, participants were asked to stare at a cross (+) that was presented on the screen for distinct amounts of time. In addition,  to control for factors like hungriness, all of participants were scanned at the same time (6pm) and were monitored and fed a controlled meal 4.5 hours prior to the scan. The image below shows a representation of the task described and the scale for rating the foods that was used in this study.

Food pleasantness rating task visual

The data collected from the study showed that both the left and right VP of the male and female participants had a positive correlation with the ratings of food pleasantness. This basically means that the higher the participant rated the image, the higher the activity of the VP was observed. In addition, the researchers also confirmed that the OFC region was also activated in a positive manner according to the ratings as it was previously described in animal studies  (Izquierdo et al., 2004).

fMRI images showing the activation of the VP (part A and the OFC (part D) brain areas.

I think that the data obtained from this study means that the activation of the OFC and VP human brain areas in the presence of pleasant foods (like the beautiful pastries I have been eating here in Paris) plays an important role on directing our food choices since we tend to pick the food we find pleasant over unpleasant ones. Maybe that’s why I keep recurring to the beautiful and yummy  French pastries since my OFC and VP are most likely activated by their pleasant looks. It would be interesting to see the extent to which the activation of these areas directs food choices or see if these areas respond any differently when the same images are presented to people with eating disorders like anorexia nervosa, bulimia nervosa, and binge-eating. It would be really cool if by performing such studies, new treatments could be developed for those eating disorders.

Well that’s all I have to share for now. Thanks for reading, I hope you enjoyed the post! Now go treat your self (and your brain) with beautiful foods that you find appealing since that is exactly what I am going to do for the next couple of days. Bon appétit!

-Maria G. Vazquez

References:

Izquierdo A, Suda RK, Murray EA.(2004) Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency. J Neurosci. Aug 25;24(34):7540-8

Smith KS, Berridge KC. (2005) The ventral pallidum and hedonic reward: neurochemical maps of sucrose “liking” and food intake. J Neurosci. 25(38):8637-49

Simmons WK, Rapuano KM, Ingeholm JE, Avery J, Kallman S, Hall KD, Martin A. (2014) The ventral pallidum and orbitofrontal cortex support food pleasantness inferences. Brain Struct Funct. 219(2):473-83.

The Lawcode of Hammurabi

Like every good tourist of Paris, yesterday I visited the Louvre with Kayleigh. This massive museum is home to breath taking paintings, gorgeous sculptures, and, what I feel far too many visitors pass by without notice, a wide array of different writings from thousands of years ago! I admit that a stone tablet might not look like much at first glance, but even the Code of Hammurabi had less than a handful of people taking pictures when we ran into it (and considering it wasn’t marked on the museum map, it was pure luck that we saw it at all).

Location of the Louvre

My first thought upon seeing these beautiful pieces of history and writing was something very appropriate and intelligent, maybe along the lines of “this is so cool!” My second set of thoughts revolved around how it would be terrible to drop a tablet and ruin who knows how many days of work, and how my clumsiness would probably make me a terrible scribe. But eventually I got around to thinking about the written languages captured on these artifacts and how they differ so much from the alphabets I am used to. Egyptian hieroglyphics aren’t entirely made of logographs– symbols that correspond to an entire word–but there are enough to make the writing system vastly different from the English alphabet. It’s easy enough to imagine that the brain might process these writing system differently. Of course, few people are fluent in reading ancient scripts, but there is a popular language today that uses logographs: Chinese.

Stele d’Ousirous with beautiful drawings and accompanying hieroglyphics

Previous research has found several differences in the brain regions used during reading more morpho-syllabic language like Chinese versus a more alphabetic language like English. However, these studies have mostly studied participants during artificial language tasks, such as trying to determine whether a stimulus is a real word. This task might be a convenient measure of language related brain activation for experimenters, but nobody in the real world runs around staring at scribbles and trying to decide if what they see is a real word. A 2015 study by Wang et al., on the other hand, looked at not only language use during these artificial language tasks, but also language use in a more naturalistic setting, like reading a story. 

Sarcophagus of Ramesses III

For these experiments, monolinguals in either English or Chinese took part in a naturalistic reading task or a lexical-decision task. In the first task, sixteen adults read and listened to six fairy tales in their respective language. For the lexical decision task, the participants had to determine whether the stimulus shown on a screen was a real word. In the English version, stimuli included real words, pseudowords, and non-words. The pseudowords were “almost” words made from a string of consonants, like “kybkh” or “wrgllt”. Non-words involved randomly rearranged letter strokes––a combination of lines that didn’t even form recognizable letters. Likewise, for the Chinese version, the participants had to determine between real phonograms, pseudo-characters, and artificial character-like stimuli. Unlike the phonograms, which are real Chinese characters that give information about the pronunciation and meaning of a word, pseudo-characters only superficially looked like real Chinese characters. In the artificial characters, either the position of character strokes was reversed or the strokes of a real character were randomly organized so that, like with the English nonwords, the resulting stimulus was nonsensical and completely meaningless.

Activity Levels in the Brain

The participants completed these tasks in an fMRI machine, which the experimenters used to measure brain activity. fMRIs measure a ratio of oxygenated to deoxygenated blood, and since more active areas of the brain require more oxygenated blood, fMRIs can indirectly measure brain activity. When Wang et al. looked at the resulting fMRI data for the lexical decision task. they found several differences in brain activation for Chinese versus English. For example, the Middle Frontal Gyrus (MFG) and the right Fusiform Gyrus (rFFG) show more activation for Chinese than English. Both of these brain areas may be involved in visual word processing, and the MFG may also be activated during meta-linguistic decision making. During the reading task, however, the main differences in the brain between Chinese and English readers involved the left Middle Temporal Gyrus (MTG) and visual areas that aren’t thought to be part of the brain’s reading network. According to Wang et al., these variations in activation may arise from the more visually complex nature of Chinese characters compared to English letters and the ability of certain Chinese characters to convey the meaning of a word without giving information on its pronunciation.

Now just where are all these brain areas I’ve listed off? Time for a mini neuroanatomy lecture! The following lovely illustrations brain give a side view of the brain, with the front of the brain towards the left and the back of the brain towards the right.

The Left Middle Frontal Gyrus

The Left Middle Temporal Gyrus

Now this next illustration of the Fusiform Gyrus is looking inside the brain, as if it were cut right down the middle between the eyes. The front of the brain is on the right side and the back of the brain is on the left.

The Right Fusiform Gyrus

So what do all of these data tell us? The gist of this study shows that the brain areas processing the Chinese writing system seem to differ slightly from the brain areas used to process English, but these differences depend on the particular language task involved. These distinctions in brain activation for the two experiments show that we can’t assume the same areas of the brain used in lab tasks like lexical decision making match the areas used in more natural tasks like story reading. Hopefully future experimenters will keep this in mind when they study language processing in the brain!

The Winged Victory of Samothrace. This statue doesn’t have much to do with writing, but she was one of my favorite things to see in the Louvre.

Exploring the Louvre was absolutely wonderful. I only wish I’d had time to see more of the artwork. With only a few days left before I leave Paris, I probably won’t get a chance to visit again during this trip, but hopefully I’ll see Paris again someday!

Bibliography

Wang X, Yang J, Yang J, Mencl WE, Shu H, Zevin JD (2015) Language differences in the brain network for reading in naturalistic story reading and lexical decision. PloS one 10:e0124388.

https://commons.wikimedia.org/wiki/File%3AGray727_fusiform_gyrus.png

https://commons.wikimedia.org/wiki/File%3AGray726_middle_temporal_gyrus.png

https://commons.wikimedia.org/wiki/File%3AGray726_middle_frontal_gyrus.png