175. Yang, J.; Zhu, B.; Zhang, J.; Liang, S. H.; Shen, S. and Ran, C. ” Half-curcumin-based chemiluminescence probes and their applications in detecting quasi-stable oxidized proteins”, Angewandte Chemie International Edition, 2024, ASAP. Link: https://doi.org/10.1002/anie.202409896
174. Li, Y.; Dahl, K.; Johnström, P.; Varnäs, K.; Farde, L.; Halldin, C.; Medd, A.; Maier, D.; Powell, M.; Chen, J.; Van, R.; Patel, J.; Chaudhary, A.; Gao, Y.; Song, Z.; Haider, A.; Shao, Y.; Elmore, C.; Liang, S. H. & Schou, M. “Radiosynthesis and Evaluation of 11C-labeled isoindolone-based positive allosteric modulators for PET imaging of Metabotropic Glutamate Receptor 2”, ACS Pharmacology & Translational Science, 2024, ASAP. DOI: 10.1021/acsptsci.4c00261.
173. Hu, J.; Li, Y.; Dong, C.; Wei, H.; Liao, K.; Wei, J.; Zhao, C.; Chaudhary, A.; Chen, J.; Xu, H.; Zhong, K.; Liang, S. H.; Wang, L. & Ye, W. “Discovery and evaluation of a novel 18F-labled vasopressin 1a receptor PET ligand with peripheral binding specificity”, Acta Pharmaceutica Sinica B, 2024, 2211-3835. Link: https://doi.org/10.1016/j.apsb.2024.05.033
172. Zhang, W.; Li, Y. and Liang, S. H. ” Radiodifluoromethylation of well-functionalized molecules“, American Journal of Nuclear Medicine and Molecular Imaging, 2024, Accepted.
171. Pees, A.; Tong, J.; Birudaraju, S.; Munot, Y. S.; Liang, S. H.; Saturnino Guarino, D.; Mach, R.; Mathis, C. A. and Vasdev, N. “Development of Pyridothiophene Compounds for PET Imaging of α-Synuclein”, Chemistry – A European Journal, 2024, e202303921.
170. Jeppesen, T. E.; Shao, T.; Chen, J.; Patel, J. S.; Zhou, X.; Kjaer, A. and Liang, S. H. “Poly (ADP-ribose) Polymerase (PARP)-targeted PET Imaging in Non-oncology Application: A Pilot Study in Preclinical Models of Nonalcoholic Steatohepatitis”, American Journal of Nuclear Medicine and Molecular Imaging, 2024, Accepted.
169. Liu, J.; Rong, J.; Wood, D. P.; Wang, Y.; Liang, S. H. and Lin, S. “Co-Catalyzed Hydrofluorination of Alkenes: Photocatalytic Method Development and Electroanalytical Mechanistic Investigation”, Journal of the American Chemical Society, 2024, accepted.
168. Chen, J.; Li, Y.; Yu, Q.; Patel, S. J.; Zhou, X.; Zhang, K.; Rong, J.; Zhao, C.; Chaudhary, F. A.; Zhang, W.; Bi, C.; Song, Z.; April T. Davenport, A. T.; Daunais, J. B.; Haider, A.; Collier, L.; Yuan, H.; and Liang, S. H. “Preclinical Evaluation of Azabenzimidazole-Based PET Radioligands for γ-8 Dependent Transmembrane AMPA Receptor Regulatory Protein Imaging”, ChemBioChem, 2024, accepted.
167. Ahmed, H.; Wang, Y.; Griffiths, W. J.; Levey, A. I.; Pikuleva, I.; Liang, S. H. and Haider, A. “Brain Cholesterol and Alzheimer’s Disease–Challenges and Opportunities in Probe and Drug Development”, Brain, 2024, accepted.
166. Chen, Z.; Chen, J.; Wakana, M.; Yi, Y.; Rong, J.; Li, Y.; Leon, C. E.; Shao, T.; Song, Z.; Yamasaki, T.; Zhang, Y.; Josephson, L.; Van, R. S.; Shao, Y.; Zhang, M-R. and Liang, S. H. “Preclinical evaluation of novel positron emission tomography (PET) probes for imaging leucine-rich repeat kinase 2 (LRRK2)”, Journal of Medicinal Chemistry, 2024, accepted.
165. Ahmed, H.; Wallimann, R.; Gisler, L.; Elghazawy, N. H.; Gruber, S.; Keller, C.; Liang, S. H.; Sippl, W.; Haider, A. and Ametamey, S. M. “Characterization of (R)- and (S)-[18F]OF-NB1 in Rodents as Positron Emission Tomography Probes for Imaging GluN2B Subunit-Containing N-Methyl-D-Aspartate Receptors”, ACS Chemical Neuroscience, 2023, 14, 4323-4334. Link: https://pubmed.ncbi.nlm.nih.gov/38060344/
164. Zhang, J.-J.; Lou, L.; Lv, R.; Chen, J.; Li, Y.; Wu, G.; Cai, L.; Liang, S. H. and Chen, Z. “Recent advances in photochemistry for positron emission tomography imaging”, Chinese Chemical Letters, 2023, accepted. Link: https://www.sciencedirect.com/science/article/abs/pii/S1001841723010938
163. Yoo, C-H; DuBois, J.; Wang, L.; Tang, Y.; Hou, L.; Xu, H.; Chen, J.; Liang, S. H.; Izquierdo Garcia, D. and Wey, H-Y. “Positron Pseudo-CT-based attenuation correction to simultaneous PET/MRI brain imaging of non-human primates” ACS Omega, 2023, 8, 45438-45446. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10702200/
162. Chen, J.; Ran, W.; Huang, Y.;Wei, J.; Rong, J.; Wei, H.; Li, Y.; Li, G.; Chen, Z.; Collier, L.; Elghazawy, N. H.; Sippl, W.; Haider, A.; Liao, K.; Dong, C.; Li, Y.; Xu, H.; He, W.; Wang, L. and Liang, S. H. “Evaluation of Thiadiazine-Based PET Radioligands for Imaging the AMPA Receptor” Biomedicine & Pharmacotherapy, 2023, 168, 115842. Link: https://pubmed.ncbi.nlm.nih.gov/37925936/
161. Korff, M.; Chaudhary, A.; Li, Y.; Zhou, X.; Zhao, C.; Rong, J.; Chen, J.; Xiao, Z.; Elghazawy, N.; Sippl, W.; Davenport, A.; Daunais, J. B.; Wang, L.; Abate, C.; Ahmed, H.; Crowe, R.; Schmidt, T. J. ; Liang, S. H.; Ametamey, S. M.; Wünsch, B.; Haider, A. “Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors” Journal of Medicinal Chemistry, 2023, 66, 16018-16031. Link: https://pubmed.ncbi.nlm.nih.gov/37979148/
160. Rong, J.; Yamasaki, T.; Li, Y.; Kumata, K.; Zhao, C.; Haider, A.; Chen, J.; Xiao, Z.; Fujinaga, M.; Hu, K.; Mori, W.; Zhang, Y.; Xie, L.; Zhou, X.; Collier, T. L.; Zhang, M.-R. and Liang, S. H. “Development of Novel 11C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging”, ACS Medicinal Chemistry Letters 2023, 14, 1419-1426. Link: https://pubmed.ncbi.nlm.nih.gov/37849554/
159. Kuang, S.; Zhu, B., Zhang, J., Yang, F., Wu, B., Ding, W., Yang, L., Shen, S., Liang, S. H., Mondal, P., Kumar, M., Tanzi, R. E., Zhang, C., Chao, H. and Ran, C. “A Photolabile Curcumin-Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Alzheimer’s Disease Treatment” Angewandte Chemie International Edition, 2023, 62, e202312519. Link: https://pubmed.ncbi.nlm.nih.gov/37721455/
158. Haider, A.; Wang, L.; Gobbi, L.; Li, Y.; Chaudhary, A.; Zhou, X.; Chen, J.; Zhao, C.; Rong, J.; Xiao, Z.; Hou, L.; Elghazawy, N.H.; Sippl, W.; Davenport, A.T.; Daunais, J.B.; Ahmed, H.; Crowe, R.; Honer, M.; Rominger, A.; Grether, U.; Liang, S. H. and Ametamey S.M. “Evaluation of [18F]RoSMA-18-d6 as a CB2 PET Radioligand in Non-Human Primates” ACS Chemical Neuroscience, 2023, 14, 3752-3760. Link: https://pubs.acs.org/doi/10.1021/acschemneuro.3c00222
157. Li, W.; Qiao, Y.; Chen, J.; Li, Y.; Du, X.; Liang, S. H. and Fu, H. “Visualizing Reactive Astrocytes: Positron Emission Tomography Imaging Ligands for Imidazoline-2 Binding Sites”, View, 2023, Accepted. Link: https://onlinelibrary.wiley.com/doi/full/10.1002/VIW.20230037
156. Song, R., Zhang, J., Perszyk, R. E., Chad, R C., Tang, W., Kannan, V., Li, J., Xu, Y., Chen, J., Li, Y., Liang, S. H., Traynelis, S. F., & Yuan, H. (2023) “Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors”, Journal of Neurochemistry, 2023, Accepted.
155. Zhang, J-J., Fu, H., Lin, R., Zhou, J. Haider, A., Fang, W., Elghazawy, N., Rong, J., Chen, J., Li, Y., Ran, C., Collier, L., Chen, Z., and Liang, S. H. “Imaging cholinergic receptors in the brain by positron emission tomography”, Journal of Medicinal Chemistry, 2023, accepted. Link: https://pubmed.ncbi.nlm.nih.gov/37649269/
154. Chasse, M., Pees, A., Lindberg, A., Liang, S. H. and Vasdev, N. “Spirocyclic Iodonium Ylides for Fluorine-18 Radiolabeling of Non-Activated Arenes: From Concept to Clinical Research”, The Chemical Record, 2023, e202300072. DOI link: doi.org/10.1002/tcr.202300072
153. Rong, J., Zhao, C., Xia, X., Li, G., Haider, A., Wei, H., Chen, J., Xiao, Z., Li, Y., Zhou, X., Xu, H., Collier, T.L., Wang, L., Liang, S. H. “Evaluation of [18F]Favipiravir in Rodents and Nonhuman Primates (NHP) with Positron Emission Tomography”, Pharmaceuticals, 2023,16(4):524. Link doi: 10.3390/ph16040524.
152. Zhu, B., Liang, S. H. and Ran, C. “Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies”, Methods in Molecular Biology, 2023, 2662:147-156. doi: 10.1007/978-1-0716-3167-6_13.
151. Guo, B., Hu, L., Cai, Q., Cheng, Y., Shang, J., Tang, Y., Ling, X., Gong, J., Liang, S. H., Wang, L. and Xu, H. “Precision of quantitative parameters of 18F-FDG PET/CT in a rabbit VX2 tumor model”, Quantitative Imaging in Medicine and Surgery, 2023. Link: https://qims.amegroups.com/article/view/112844
150. Haider, A., Elghazawy, N. H., Dawood, A., Gebhard, C., Wichmann, T., Sippl, W., Hoener, M., Arenas, E. and Liang, S. H. “Translational molecular imaging and drug development in Parkinson’s disease”, Molecular Neurodegeneration, 2023, 18(1):11. doi: 10.1186/s13024-023-00600-z. Link: https://pubmed.ncbi.nlm.nih.gov/36759912/
149. Rong, J., Haider, A., Jeppesen, T. E., Josephson, L. & Liang, S. H. “Radiochemistry for Positron Emission Tomography”, Nature Communications, 2023, 14, 3257. Link: https://pubmed.ncbi.nlm.nih.gov/37277339/
148. Tan, Z., Haider, A., Zhang, S., Chen, J., Wei, J., Liao, K., Li, G., Wei, H., Dong, C., Ran, W., Li, Y., Li, Y., Rong, J., Li, Y., Liang, S. H., Xu, H. and Wang, L. “Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [18F]LW223 as a TSPO-targeted PET radioligand”, Pharmacological Research, 2023, 189, 106681. Link: https://pubmed.ncbi.nlm.nih.gov/36746361/
147. Zeng, X.; Wang, C.; Yan, W.; Rong, J.; Song, Y.; Xiao, Z.; Cai, A.; Liang, S. H. and Liu, W. “Aryl Radical Enabled, Copper–Catalyzed Sonogashira-Type Cross-Coupling of Alkynes with Alkyl Iodides”, ACS Catalysis, 2023, 13, 4, 2761–2770. Link: https://pubs.acs.org/doi/10.1021/acscatal.2c05901
146. Yamasaki, T., Ishii, H., Hiraishi, A., Kumata, K., Wakizaka, H., Zhang, Y., Kurihara, Y., Ogawa, M., Nengaki, N., Chen, J., Li, Y., Liang, S. H. and Zhang M.-R. “Small-animal PET study for noninvasive quantification of transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) in the brain”, Journal of Cerebral Blood Flow & Metabolism, 2023, 43, 893-904. Link: https://journals.sagepub.com/doi/10.1177/0271678X231152025
145. Yoo, C.H., Chen, Z., Rani, N., Chen, J., Rong, J., Chen, L., Zhang, L., Liang, S. H. and Wey, H. Y. “Evaluation of [18F]PF-06455943 as a Potential LRRK2 PET Imaging Agent in the Brain of Nonhuman Primates”, ACS Chemical Neuroscience, 2023, 14, 370-377. Link: https://pubmed.ncbi.nlm.nih.gov/36630128/
144. Haider, A., Zhao, C., Wang, L., Xiao, Z., Rong, J., Xia, X., Chen, Z., Pfister, S. K., Mast, N., Yutuc, E., Chen, J., Li, Y., Shao, T., Warnock, G. I., Dawoud, A., Connors, T. R., Oakley, D.H., Wei, H., Wang, J., Zheng, Z., Xu, H., Davenport, A. T., Daunais, J. B., Van, R. S., Shao, Y., Wang, Y., Zhang, M. R., Gebhard, C., Pikuleva, I., Levey, A. I., Griffiths, W.J. and Liang, S. H. “Assessment of cholesterol homeostasis in the living human brain”, Science Translational Medicine, 2022, 14(665), eadc9967. doi: 10.1126/scitranslmed.adc9967. Epub 2022 Oct 5. Link: https://pubmed.ncbi.nlm.nih.gov/36197966/
143. Chen, Z., Chen, J., Chen, L., Yoo, C. H., Rong, J., Fu, H., Shao, T., Coffman, K., Steyn, S. J., Davenport, A. T., Daunais, J. B., Haider, A., Collier, L., Josephson, L., Wey, H. Y., Zhang, L. and Liang. S. H. “Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand”, Journal of Medicinal Chemistry, 2023, 66, 1712-1724. Link: https://pubmed.ncbi.nlm.nih.gov/36256881/
142. Fu, H.; Rong, J.; Chen, Z.; Zhou, J.; Collier, T. and Liang, S. H. “Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors”, Journal of Medicinal Chemistry, 2022, 65, 10755-10808. Link: https://doi.org/10.1021/acs.jmedchem.2c00633
141. Haider, A.; Deng, X.; Mastromihalis, O.; Pfister, S. K.; Jeppesen, T. E.; Xiao, Z.; Pham, V.; Sun, S.; Rong, J.; Zhao, C.; Chen, J.; Li, Y.; Connors, T. R.; Davenport, A. T.; Daunais, J. B.; Hosseini, V.; Ran, W.; Christopoulos, A.; Wang, L.; Valant, C. and Liang, S. H. “Structure-Activity Relationship of Pyrazol-4-yl-Pyridine Derivatives and Identification of a Radiofluorinated Probe for Imaging the Muscarinic Acetylcholine Receptor M4”, Acta Pharmaceutica Sinica B, 2022, accepted. Link: https://pubmed.ncbi.nlm.nih.gov/36815036/
140. Ahmed, H; Gisler, L.; Elghazawy, E. H.; Keller, C.; Sippl, W.; Liang, S. H.; Haider, A and Ametamey, S. M. “Development and Validation of [3H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs”, Pharmaceuticals, 2022, accepted. Link: https://pubmed.ncbi.nlm.nih.gov/36015108/
139. Yu, Q.; Kumata, K.; Rong, J.; Chen, Z.; Yamasaki, T.; Chen, J.; Xiao, Z.; Ishii, H.; Hiraishi, A.; Shao, T.; Zhang, Y.; Hu, K.; Xie, L.; Fujinaga, M.; Zhao, C.; Mori, W.; Collier, T.; Haider, A.; Tomita, S.; Zhang, M.-R. and Liang, S. H. “Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography”, Journal of Medicinal Chemistry, 2022, accepted. Link: https://pubmed.ncbi.nlm.nih.gov/35762919/
138. Zhang, W.; Deng, X.; Zhang, F.-X.; Lin, J.-H.; Xiao, J.-C. and Liang, S. H. “The Synthesis and 18F-Labeling of Alkenyl Sulfonyl Fluorides via an Unconventional Elimination Pathway”, Organic Letters, 2022, accepted. Link: https://pubmed.ncbi.nlm.nih.gov/35771975/
137. Bhere, D.; Choi, S. H.; van de Donk, P.; Hope, D.; Gortzak, K.; Kunnummal, A.; Khalsa, J.; Revai Lechtich, E.; Reinshagen, C.; Leon, V.; Nissar, N.; Bi, W. L.; Feng, C.; Li, H.; Zhang, Y. S.; Liang, S. H.; Vasdev, N.; Essayed, W.; Quevedo, P. V.; Golby, A.; Banouni, N.; Palagina, A.; Abdi, R.; Fury, B.; Smirnakis, S.; Lowe, A.; Reeve, B.; Hiller, A.; Chiocca, E. A.; Prestwich, G.; Wakimoto, H.; Bauer, G.; Shah, K. “Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells”, Nature Communications, 2022, 13, 2810. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120173/.
136. Cheng, R.; Fujinaga, M.; Yang, J.; Rong, J.; Haider, A.; Ogasawara, D.; Van, R. S.; Shao, T.; Chen, Z.; Zhang, X.; Calderon Leon, E. R.; Zhang, Y.; Mori, W.; Kumata, K.; Yamasaki, T.; Xie, L.; Sun, S.; Wang, L.; Ran, C.; Shao, Y.; Cravatt, B.; Josephson, L.; Zhang, M. R. and Liang, S. H. “A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network”, Acta Pharmacologica Sinica, 2022, accepted. https://pubmed.ncbi.nlm.nih.gov/35513432/.
135. Bengs, S.; Warnock, G. I.; Portmann, A.; Mikail, N.; Rossi, A.; Ahmed, H.; Etter, D.; Treyer, V.; Gisler, L.; Pfister, S. K.; Jie, C.; Meisel, A.; Keller, C.; Liang, S. H.; Schibli, R.; Mu, L.; Buechel, R. R.; Kaufmann, P. A.; Ametamey, S. M.; Gebhard, C. and Haider, A. “Rest/stress myocardial perfusion imaging by positron emission tomography with 18F-Flurpiridaz: A feasibility study in mice”, Journal of Nuclear Cardiology, 2022, doi: 10.1007/s12350-022-02968-9. Link: https://pubmed.ncbi.nlm.nih.gov/35484467/
134. Shao, T.; Chen, Z.; Cheng, R.; Collier, L.; Josephson, L.; Chung, R. T. and Liang, S. H. “Preliminary evaluation of [11C]MAGL-0519 as a promising PET ligand for the diagnosis of Hepatocellular carcinoma”, Bioorganic Chemistry, 2022, 120, 105620. https://www.sciencedirect.com/science/article/abs/pii/S0045206822000256
133. Chen, Z.; Haider, A.; Chen, J.; Xiao, Z.; Gobbi, L.; Honer, M.; Grether, U.; Arnold, S.; Josephson, L. and Liang, S. H. “The repertoire of small molecule PET probes for neuroinflammation imaging: challenges and opportunities beyond TSPO”, Journal of Medicinal Chemistry, 2021, accepted. Link: https://pubmed.ncbi.nlm.nih.gov/34905377/
132. Deng, X.; Salgado-Polo, F.; Shao, T.; Xiao, Z.; Van, R.; Chen, J.; Rong, J.; Haider, A.; Shao, Y.; Josephson, L.; Perrakis, A. and Liang, S. H. “Imaging autotaxin in vivo with 18F-labeled positron emission tomography ligands”, Journal of Medicinal Chemistry, 2021, 64, 15053-15068. Link: https://pubmed.ncbi.nlm.nih.gov/34662125/
131. Rong, J.; Mori, W.; Xia, X.; Schafroth, M. A.; Zhao, C.; Van, R. S.; Yamasaki, T.; Chen, J.; Xiao, Z.; Haider, A.; Ogasawara, D.; Hiraishi, A.; Shao, T.; Zhang, Y.; Chen, Z.; Pang, F.; Hu, K.; Xie, L.; Fujinaga, M.; Kumata, K.; Gou, Y.; Fang, Y.; Gu, S.; Wei, H.; Bao, L.; Xu, H.; Collier, T. L.; Shao, Y.; Carson, R. E.; Cravatt,B. F.; Wang,L.; Zhang, M.-R. and Liang S. H. “Novel reversible-binding PET ligands for imaging monoacylglycerol lipase based on piperazinyl azetidine scaffold”, Journal of Medicinal Chemistry, 2021, 64, 14283-14298. Link: https://pubmed.ncbi.nlm.nih.gov/34569803/
130. Xiao, Z.; Wei, H.; Xu, Y.; Haider, A.; Wei, J.; Yuan, S.; Rong, J.; Zhao, C.; Li, G.; Zhang, W.; Chen, H.; Li, Y.; Zhang, L.; Sun, J.; Zhang, S.; Luo, H.-B.; Yan, S.; Cai, Q.; Hou, L.; Che, C.; Liang, S. H. and Wang, L. “Discovery of a highly specific 18F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination”, Acta Pharmaceutica Sinica B, 2021, ASAP. Link: https://www.sciencedirect.com/science/article/pii/S2211383521004470
129. Haider, A; Xiao, Z; Xia, X; Chen, J; Van, RS; Kuang, S; Zhao, C; Rong, J; Shao, T; Ramesh, P; Aravind, A; Shao, Y; Ran, C; Young, LJ; Liang, S. H. “Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging”. Pharmacological Research, 2021, accepted, Link: https://doi.org/10.1016/j.phrs.2021.105886
128. Yamasaki, T; Hatori, A; Zhang, Y; Mori, W; Kurihara, Y; Ogawa, M; Wakizaka, H; Rong, J; Wang, L; Liang, S. H. and Zhang, M-R. “Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study”, Theranostics, 2021, 11, 9492–9502. Link: https://pubmed.ncbi.nlm.nih.gov/34646382/
127. Shao, T.; Chen, Z.; Rong, J.; Belov, V.; Chen, J.; Jeyarajab, A.; Deng, X.; Fu, H.; Yu, Q.; Rwema, S.; Lin, W.; Papisov, M.; Josephson, L.; Chung, R. and Liang, S. H. “[18F]-MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models”, Acta Pharmaceutica Sinica B,2021, accepted. Link: https://pubmed.ncbi.nlm.nih.gov/35127387/
126. Sun, J.; Xiao, Z.; Haider, A.; Gebhard, C.; Xu, H.; Luo, H. B.; Zhang, H. T.; Josephson, L.; Wang, L. and Liang, S. H. “Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery”, Journal of Medicinal Chemistry, 2021, accepted. DOI:
https://pubmed.ncbi.nlm.nih.gov/34042442/
125. Deppen, J. N.; Ginn, S. C.; Kim, N. H.; Wang, L.; Voll, R.J.; Liang, S. H.; Goodman, M.M.; Oshinski, J. N. and Levit, R. D. “A Swine Hind Limb Ischemia Model Useful for Testing Peripheral Artery Disease Therapeutics”, Journal of Cardiovascular Translational Research, 2021, accepted. DOI: https://link.springer.com/article/10.1007/s12265-021-10134-8
124. Sun, J.; Chen, J.; Kumata, K.; Xiao, Z.; Rong, J.; Haider, A.; Shao, T.; Wang, L.; Xu, H.; Zhang, M.-R. and Liang, S. H. “Imaging the trace amine-associated receptor 1 by positron emission tomography”, Tetrahedron Letters, 2021, 153007. https://www.sciencedirect.com/science/article/abs/pii/S0040403921002033
123. Zhang, X.; Xiao, Z.; Kumata, K.; Yamasaki, T.; Josephson, L.; Zhang, M.-R.; Wang, L. and Liang, S. H. “Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand. In Metabotropic Glutamate Receptor Technologies”, Olive, M. F.; Burrows, B. T.; Leyrer-Jackson, J. M., Eds. Springer US: New York, NY, 2021; pp 23-37. https://link.springer.com/protocol/10.1007%2F978-1-0716-1107-4_2
122. Knight, A.C.; Varlow, C.; Zi, T.; Liang, S. H.; Josephson, L.; Schmidt, K.; Patel, S. and Vasdev, N. “In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R” ACS Chemical Neuroscience, 2021, accepted. https://pubmed.ncbi.nlm.nih.gov/33667059/
121. Rong, J.; Haider, A. and Liang, S. H. “Precision Radiochemistry for Fluorine-18 Labeling of PET Tracers”. In Organofluorine Chemistry: Synthesis, Modeling, and Applications, 2021; pp 397-425. Editor(s): Kálmán Szabó & Nicklas Selander. WILEY‐VCH GmbH, Boschstr. https://onlinelibrary.wiley.com/doi/book/10.1002/9783527825158
120. Chen, Z.; Mori, W.; Rong, J.; Schafroth, M. A.; Shao, T.; Van, R. S.; Ogasawara, D.; Yamasaki, T.; Hiraishi, A.; Hatori, A.; Chen, J.; Zhang, Y.; Hu, K.; Fujinaga, M.; Sun, J.; Yu, Q.; Collier, T. L.; Shao, Y.; Cravatt, B. F.; Josephson, L.; Zhang, M-R. and Liang, S. H. “Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping” Acta Pharmaceutica Sinica B, 2021, accepted. DOI: https://www.sciencedirect.com/science/article/pii/S2211383521000381
119. Hou, L.; Rong, J.; Haider, A.; Ogasawara, D.; Varlow, C.; Schafroth, M. A.; Mu, L.; Gan, J.; Xu, H.; Fowler, C. J.; Zhang, M-R.; Vasdev, N.; Ametamey, S.; Cravatt, B. F.; Wang, L. and Liang, S. H. “Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development” Journal of Medicinal Chemistry, 2021, accepted. https://pubmed.ncbi.nlm.nih.gov/33379862/
118. Zhang, X.; Zhang, Y.; Chen, Z.; Shao, T.; Van, R.; Kumata, K.; Deng, X.; Fu, H.; Yamasaki, T.; Rong, J.; Hu, K.; Hatori, A.; Xie, L.; Yu, Q.; Ye, W.; Xu, H.; Sheffler, D. J.; Cosford, N. D. P.; Shao, Y.; Tang, P.; Wang, L.; Zhang, M.-R. and Liang, S. H. “Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2″ Theranostics, 2020, 10, 11178-11196. https://pubmed.ncbi.nlm.nih.gov/33042277/
117. Yamasaki, T.; Zhang, X.; Kumata, K.; Zhang, Y.; Deng, X.; Fujinaga, M.; Chen, Z.; Mori, W.; Hu, K; Wakizaka, H; Hatori, A.; Xie, L.; Ogawa, M.; Nengaki, N.; Van, R.; Shao, Y.; Sheffler, D. J.; Cosford, N. D. P.; Liang, S. H. and Zhang, M.-R. “Identification and Development of A New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2)”, Journal of Medicinal Chemistry, 2020, accepted. https://pubmed.ncbi.nlm.nih.gov/32960052/
116. Zhang, L.; Hu, K.; Shao, T.; Hou, L.; Zhang, S.; Ye, W.; Josephson, L.; Meyer, J. H.; Zhang, M.-R.; Vasdev, N.; Wang, J.; Xu, H.; Wang, L. and Liang, S. H. “Recent developments on PET radiotracers for TSPO and their applications in neuroimaging” Acta Pharmaceutica Sinica B, 2021, 11, 373-393. https://pubmed.ncbi.nlm.nih.gov/33643818/
115. Chen, Z.; Hou, L.; Gan, J.; Cai, Q.; Ye, W.; Chen, J.; Tan, Z.; Zheng, C.; Li, G.; Xu, H.; Fowler, C. J.; Liang, S. H. and Wang, L. “Synthesis and Preliminary Evaluation of a Novel Positron Emission Tomography (PET) Ligand for Imaging Fatty Acid Amide Hydrolase (FAAH)” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127513. DOI: https://doi.org/10.1016/j.bmcl.2020.127513
114. Sun, J., Kumata, K., Chen, Z., Zhang, Y., Chen, J., Hatori, A., Fu, H., Rong, J., Deng, X., Yamasaki, T., Xie, L., Hu, K., Yu, Q., Shao, T., Collier, T. L., Josephson, L., Shao, Y., Du, Y., Wang, L., Xu, H., Zhang, M.-R. and Liang, S. H. “Synthesis and Preliminary Evaluation of Novel 11C-Labeled GluN2B-selective NMDA Receptor Negative Allosteric Modulators” Acta Pharmacologica Sinica, 2020, accepted. Link: https://pubmed.ncbi.nlm.nih.gov/32661351/
113. Brugarolas, P., Comstock, J., Dick, D. W., Ellmer, T., Engle, J. W., Lapi, S. E., Liang, S. H., Parent, E. E., Kishore, Pillarsetty N. V., Selivanova, S., Sun, X., Vavere, A., Scott, P. J. H., and Society of Nuclear Medicine and Molecular Imaging Radiopharmaceutical Sciences Council. “Fifty Years of Radiopharmaceuticals” Journal of Nuclear Medicine Technology, 2020, 48 (Suppl 1), S34-39. PMID: 32605944.
112. Varlow, C., Boileau, I., Wey, H-Y., Liang, S. H. and Vasdev, N. “Classics in Neuroimaging: Imaging the Endocannabnoid Pathway with PET” ACS Chemical Neuroscience, 2020, 11, 1855-1862. https://pubmed.ncbi.nlm.nih.gov/32559067/
111. Deng, X., Zhang, Y., Chen, Z., Kumata, K., Van, R., Rong, J., Shao, T., Hatori, A., Mori, W., Yu, Q., Hu, K., Fujinaga, M., Wey, H.-Y., Shao, Y., Josephson, L., Murtas, G., Pollegioni, L., Zhang, M.-R., and Liang, S. H. “Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127326. DOI: https://pubmed.ncbi.nlm.nih.gov/32631531/
110. Hu, K., Xie, L., Zhang, Y., Hanyu, M., Yang, Z., Nagatsu, K., Suzuki, H., Ouyang, J., Ji, X., Wei, J., Xu, H., Farokhzad, O. C., Liang, S. H.,* Wang, L.,* Tao, W.,* Zhang, M.-R.* “Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy”, Nature Communications, 2020, 11, 2778. Link:https://pubmed.ncbi.nlm.nih.gov/32513979/
109. Deng, X., Zhang, Y., Rong, J., Kumata, K., Shao, T., Wang, G., Hatori, A., Mori, W., Yu, Q., Hu, K., Fujinaga, M., Shao, Y., Josephson, L., Sun, S., Zhang, M.-R., and Liang, S. H. “Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4” Tetrahedron Letters,2020, 61, 152060. https://doi.org/10.1016/j.tetlet.2020.152060
108. Chen, Z., Chen, J., Mast, N., Rong, J., Deng, X., Shao, T., Fu, H., Yu, Q., Sun, J., Shao, Y., Josephson, L., Collier, T. L., Pikuleva, I. and Liang, S. H. “Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using ‘in-loop’ 11CO2 fixation method” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127068. https://pubmed.ncbi.nlm.nih.gov/32178974/
107. Xiao, Z., Wang, L., Wei, J., Ran, C., Liang, S. H., Shang, J., Chen, G. Y. and Zheng, C. “Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds” Chemical Communications, 2020, 56, 4164-4167. https://pubmed.ncbi.nlm.nih.gov/32207477/
106. Shao, T., Chen, Z., Belov, V., Wang, X., Rwema, S., Kumar, V., Fu, H., Deng, X., Rong, J., Yu, Q., Lang, L., Lin, W., Josephson, L., Samir, A., Chen, X., Chung, R. and Liang, S. H. “[18F]-Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosis” Journal of Hepatology, 2020, 73, 161-169. https://pubmed.ncbi.nlm.nih.gov/32145257/
105. Liang, J., Huang, Y. Y., Zhou, Q., Cao, Y., Li, Z., Wu, D., Yu, S., Guo, L., Chen, Z., Huang, L., Liang, S. H., He, X., Wu, R. and Luo H. B. “Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia” Journal of Medicinal Chemistry, 2020, 63, 3370-3380. https://pubmed.ncbi.nlm.nih.gov/32115956/
104. Varlow, C., Murrell, E., Holland, J. P., Kassenbrock, A., Shannon, W., Liang, S. H., Vasdev, N. and Stephenson, N. A. “Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease” Molecules, 2020, accepted. https://pubmed.ncbi.nlm.nih.gov/32098347/
103. Lin, X. P., Xiao, Z. Z., Chen, T., Liang, S. H. and Guo, H. Q. “Glucose Metabolism on Tumor Plasticity, Diagnosis and Treatment” Frontiers in Oncology, 2020, accepted.
102. Chen, J., Gan, J., Sun, J., Chen, Z., Fu, H., Rong, J., Deng, X., Shang, J., Gong, J., Collier, L., Wang, L., Xu, H. and Liang, S. H. “Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors” Tetrahedron Letters, 2020, 61, 151635. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062035/
101. Yu, Q., Kumata, K., Li, H., Zhang, Y., Chen, Z., Zhang, X., Shao, T., Hatori, A., Yamasaki, T., Xie, L., Hu, K., Wang, G., Josephson, L., Sun, S., Zhang, M-R. and Liang, S. H. “Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 126879. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045276/
100. Liang, S. H., Wang, L., Stephenson, N. A., Rotstein, B. H., and Vasdev, N. “Facile 18F Labeling of Non-activated Arenes via a Spirocyclic Iodonium(III) Ylide Method and its Application in the Synthesis of the mGluR5 PET Radiopharmaceutical [18F]FPEB”, Nature Protocol, 2019, 14, 1530-1545. Link: https://pubmed.ncbi.nlm.nih.gov/30980032/
99. Hu, K., Yang, Z.M., Zhang, L.L., Xie, L., Wang, L., Xu, H., Josephson, L., Liang, S. H. and Zhang, M.-R. “Boron agents for neutron capture therapy” Coordination Chemistry Reviews,2020, 405, 213139. https://www.sciencedirect.com/science/article/abs/pii/S0010854519304916
98. Yu, H., Zhao, W., Zhou, Y., Cheng, G-J., Sun, M., Wang, L., Yu, L., Ran, C. and Liang, S. H. “Salen-based Bifunctional Chemosensor for Copper (II) Ions: Inhibition of Copper-induced Amyloid-β Aggregation” Analytica Chimica Acta, 2020, 1097:144-152. Link: https://pubmed.ncbi.nlm.nih.gov/31910954/.
97. Bernard-Gauthier, V., Mossine, A.V., Knight, A., Patnaik, D., Zhao, W., Cheng, C., Krishnan, H.S., Xuan, L.L., Chindavong, P.S., Reis, S.A., Chen, J.M., Shao, X., Stauff, J., Arteaga, J., Sherman, P.S., Salem, N., Bonsall, D., Amaral, B., Varlow, C., Wells, L., Martarello, L., Patel, S., Liang, S.H., Kurumbail, R.G., Haggarty, S.J., Scott, P.J.H., Vasdev, N. “Structural Basis for Achieving GSK-3beta Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery” Journal of Medicinal Chemistry, 2019, ASAP, DOI: 10.1021/acs.jmedchem.9b01030.
96. Chen, Z., Mori, W., Fu, H., Schafroth, M. A., Hatori, A., Shao, T., Zhang, G., Van, R. S., Zhang, Y., Hu, K., Fujinaga, M., Wang, L., Belov, V., Ogasawara, D., Giffenig, P., Deng, X., Rong, J., Yu, Q., Zhang, X., Papisov, M. I., Shao, Y., Collier, T. L., Ma, J.-A., Cravatt, B. F., Josephson, L., Zhang, M.-R., and Liang, S. H. “Design, Synthesis and Evaluation of 18F-labeled Monoacylglycerol lipase Inhibitors as Novel Positron Emission Tomography Probes” Journal of Medicinal Chemistry, 2019, 62, 8866-8872. DOI: 10.1021/acs.jmedchem.9b00936.
95. Nie, B., Wang, L., Hu, Y., Liang, S., Tan, Z., Chai, P., Tang, Y., Shang, J., Pan, Z., Zhao, X., Zhang, X., Gong, J., Zheng, C., Xu, H., Wey, H.-Y., Liang, S. H., and Shan, B. “A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model” NeuroImage, 2019, ASAP, DOI: 10.1016/j.neuroimage.2019.116163
94. Wang, L., Yao, S., Tang, R., Zhu, H., Zhang, L., Gong, J., Chen, Q., Collier, T. L., Xu, H., and Liang, S. H. “A concisely automated synthesis of TSPO radiotracer [18F]FDPA based on spirocyclic iodonium ylide (SCIDY) method and validation for human use” Journal of Labelled Compounds and Radiopharmaceuticals, 2019, accepted.
93. Chen, Z., Shao, T., Gao, W., Fu, H., Collier, T. L., Rong, J., Deng, X., Yu, Q., Zhang, X., Davenport, A. T., Daunais, J. B., Wey, H. Y., Shao, Y., Josephson, L., Qiu, W., and Liang, S. H. “Synthesis and Preliminary Evaluation of [11C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson’s Disease” ChemMedChem, 2019, 14, 1580-1585.
92. Zhang, B., Fraser, B. H., Klenner, M. A., Chen, Z., Liang, S. H., Massi, M., Robinson, A. J. and Pascali, G. “[18F]Ethenesulfonyl fluoride as a novel radiofluoride relay reagent” Chemistry – A European Journal, 2019, accepted. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201900930
91. Chen, Z., Mori, W., Deng, X., Cheng, R., Ogasawara, D., Zhang, G., Schafroth, M. A., Dahl, K., Fu, H., Hatori, A., Shao, T., Zhang, Y., Yamasaki, T., Zhang, X., Rong, J., Yu, Q., Hu, K., Fujinaga, M., Xie, L., Kumata, K., Gou, Y., Chen, J., Gu, S., Bao, L., Wang, L., Collier, T. L., Vasdev, N., Shao, Y., Ma, J.-A., Cravatt, B. F., Fowler, C., Josephson, L., Zhang, M.-R. and Liang, S. H. “Design, Synthesis and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a ‘Tail Switching’ Strategy on a Piperazinyl Azetidine Skeleton” Journal of Medicinal Chemistry, 2019, 62, 3336-3353. https://pubmed.ncbi.nlm.nih.gov/30829483/
90. Yang, J., Cheng, R., Fu, H., Yang, J., Kumar, M., Lu, J., Xu, Y., Liang, S. H., Cui, M. and Ran, C. “Half-curcumin analogues as PET imaging probes for Amyloid beta species” Chemical Communications, 2019, 55, 3630-3633. https://pubmed.ncbi.nlm.nih.gov/30849141/
89. Shao, T., Josephson, L. and Liang, S. H. “Molecular Probes for Diagnosis and Staging of Non-Alcoholic Fatty Liver Disease” Molecular Imaging, 2019, 18: 1536012119871455. https://pubmed.ncbi.nlm.nih.gov/31478458/
88. Fu, H., Tang, W., Chen, Z., Belov, V., Zhang, G., Shao, T., Zhang, X., Yu, Q., Rong, J., Deng, X., Han, W., Myers, S., Giffenig, P., Wang, L., Josephson, L., Shao, Y., Davenport, A., Daunais, J., Papisov, M., Yuan, H., Li, Z., Traynelis, S. and Liang, S. H. “Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist ([18F]N2B-0518) as PET Imaging Probe for GluN2B Subunit in the Brain” ACS Chemical Neuroscience, 2019, 10, 2263-2275. https://pubmed.ncbi.nlm.nih.gov/30698943/
87. Deng, X., Hatori, A., Chen, Z., Kumata, K., Shao, T., Zhang, X., Yamasaki, T., Hu, K., Yu, Q., Ma, L., Wang, G., Wang, L., Shao, Y., Josephson, L., Sun, S., Zhang, M-R. and Liang, S. H. “Synthesis and Preliminary Evaluation of 11C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4″ ChemMedChem, 2019, ASAP, DOI: 10.1002/cmdc.201800710.
86. Zhao, S., Wang, H., Sun, S., Guo, H., Chen, Z., Wang, J., Wang, L., Liang, S. H., and Wang, G. “An efficient synthesis of 2-isoxazolines from α-haloketone oximes and dimethyl sulfonium salts” Tetrahedron Letters, 2019, ASAP, DOI:10.1016/j.tetlet.2018.12.062.
85. Lin, J-H., Deng, X., Xiao, J-C., and Liang, S. H. “Recent advances in 18F-labeling of trifluoromethylthiolation”, in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2019, accepted.
84. Rong, J., Chen, Z., Vasdev, N. and Liang, S. H. “Aryl-18F bond formation from nucleophilic [18F]fluoride”, in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2019, page 617-648.
83. Josephson, L., Stratman, N., Liu, Y., Qian, F., Liang, S. H., Vasdev, N. and Patel, S. “The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils” Molecular Imaging, 2018, 17:1536012118796297. DOI: https://pubmed.ncbi.nlm.nih.gov/30213230/
82. Fu, H., Chen, Z., Josephson, L., Li, Z. and Liang, S. H. “Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-methyl-D-aspartate (NMDA), alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) and Kainate Receptors” Journal of Medicinal Chemistry, 2019, 62, 403-419. DOI: https://pubmed.ncbi.nlm.nih.gov/30110164/. PMID: 30110164
81. Chen, Z., Mori, W., Zhang, X., Yamasaki, T., Dunn, P. J., Zhang, G. W., Fu, H., Shao, T., Zhang, Y., Hatori, A., Ma, L., Fujinaga, M., Xie, L., Deng, X., Li, H., Yu, Q., Rong, J., Josephson, L., Ma, J., Shao, Y., Tomita, S., Zhang, M. R., and Liang, S. H. “Synthesis and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging studies towards γ8-dependent transmembrane AMPA receptor regulatory protein.” European Journal of Medicinal Chemistry, 2018, 157, 898-908. PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245653/
80. Cheng, S., Jacobson, O., Zhu, G., Chen, Z., Liang, S. H., Tian, R., Yang, Z., Niu, G., Zhu, X and Chen, X. “PET imaging of EGFR expression using an 18F-labeled RNA aptamer.” European Journal of Nuclear Medicine and Molecular Imaging, 2019, 46, 948-956. https://pubmed.ncbi.nlm.nih.gov/30069577/
79. Zheng, C., Wang, Y., Xu, Y., Chen, Z., Chen, G., and Liang, S. H. “Ru-Photoredox-Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids through N-(acyloxy)phthalimide” Organic Letters, 2018, 20, 4824-4827. https://pubmed.ncbi.nlm.nih.gov/30070856/
78. Deng, X.; Rong, J.; Wang, L.; Vasdev, N.; Zhang, L.; Josephson, L. and Liang, S. H. “Chemistry for Positron Emission Tomography: Recent Advances in 11C-, 18F-, 13N- and 15O-labeling Reactions” Angewandte Chemie International Edition, 2018, 58, 2580-2605. DOI: https://pubmed.ncbi.nlm.nih.gov/30054961/
77. Rong, J. and Liang, S. H. “Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography”, in Synthetic Organofluorine Chemistry, Springer, Hu, J. & Umemoto, T., Eds. Springer Singapore: Singapore, 2018; pp 1-14.
76. Yamasaki, T., Mori, W., Zhang, Y., Hatori, A., Fujinaga, M., Wakizaka, H., Kurihara, Y., Wang, L., Nengaki, N., Ohya, T., Liang, S. H. and Zhang, M-R. “First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR127303″ NeuroImage, 2018, 176, 313-320. https://pubmed.ncbi.nlm.nih.gov/29738910/
75. Collier, T. L.; Dahl, K.; Stephenson, N. A.; Holland, J. P.; Riley, A.; Liang, S. H. and Vasdev, N. “Recent applications of a single quadrupole mass spectrometer in 11C, 18F and radiometal chemistry” Journal of Fluorine Chemistry, 2018, 210, 46-55. DOI: https://www.sciencedirect.com/science/article/abs/pii/S002211391730516X
74. Cheng, R.; Mori, W.; Ma, L.; Alhouayek, M.; Hatori, A.; Zhang, Y.; Ogasawara, D.; Yuan, G.; Chen, Z.; Zhang, X.; Shi, H.; Yamasaki, T.; Xie, L.; Kumata, K.; Fujinaga, M.; Nagai, Y.; Minamimoto, T.; Svensson, M.; Wang, L.; Du, Y.; Ondrechen, M.; Vasdev, N.; Cravatt, B. F.; Fowler, C.; Zhang, M-R. and Liang, S. H. “In vitro and in vivo evaluation of 11C-labeled azetidine-carboxylates for imaging monoacylglycerol lipase by PET imaging studies” Journal of Medicinal Chemistry, 2018, 61, 2278-2291. https://pubmed.ncbi.nlm.nih.gov/29481079/
73. Krishnan, H. S.; Bernard-Gauthier, V.; Placzek, M. S.; Dahl, K.; Narayanaswami, V.; Livni, E.; Chen, Z.; Yang, J.; Collier, T. L.; Ran, C.; Hooker, J. M.; Liang, S. H. and Vasdev, N. “Metal protein-attenuating compound for PET neuroimaging: synthesis and preclinical evaluation of [11C]PBT2” Molecular Pharmaceutics, 2018, 15, 695-702. https://pubmed.ncbi.nlm.nih.gov/29298483/
72. Collier, T. L.; Liang, S. H.; Mann, J. J.; Vasdev, N. and Kumar, J. S. D. “Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors” Beilstein Journal of Organic Chemistry, 2017, 13, 2922-2927. DOI: 10.3762/bjoc.13.285 [full-text]
71. Bernard-Gauthier, V.; Legage, M.; Waengler, B.; Bailey, J. A.; Liang, S. H.; Perrin, D.; Vasdev, N. and Schirrmacher, R. “Recent advances in fluorine-18 radiochemistry: Focus on B-18F, Si-18F, Al-18F and C-18F radiofluorination via spirocyclic iodonium ylides” Journal of Nuclear Medicine, 2018, 59, 568-572. https://pubmed.ncbi.nlm.nih.gov/29284673/
70. Zhang, X.; Kumata, K.; Yamasaki, T.; Cheng, R.; Hatori, A.; Ma, L.; Zhang, Y.; Wang, L.; Kang, H. J.; Sheffler, D. J.; Cosford, N. D. P.; Zhang, M-R & Liang, S. H. “Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide for Imaging of Metabotropic Glutamate Receptor 2″ ACS Chemical Neuroscience, 2017, 8, 1937-1948. https://pubmed.ncbi.nlm.nih.gov/28565908/
69. Collier, T. L.; Maresca K. P.; Normandin, M. D.; Richardson, P.; McCarthy, T. J.; Liang, S. H.; Waterhouse, R. N. & Vasdev, N. “Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET” Molecular Imaging, 2017, DOI: 10.1177/1536012117736669. [link]
68. Bernard-Gauthier, V.; Collier, T. L.; Liang, S. H. & Vasdev, N. “Discovery of PET Radiopharmaceuticals at the Academia-Industry Interface” Drug Discovery Today: Technologies, 2017, accepted. [link]
67. Ran, C.; Albrecht, D. S.; Bredella, M. A.; Yang, J.; Yang, J.; Liang, S. H.; Cypress, A. M.; Loggia, M. L.; Atassi, N. & Moore, A. “PET imaging of human brown adipose tissue with TSPO tracer [11C]PBR28″ Molecular Imaging and Biology, 2017, accepted. [link]
66. Yuan, G.; Jankins, T. C.; Patrick, C. G.; Philbrook, P.; Sears, O.; Hatfield, S.; Sitkovsky, M.; Vasdev, N.; Liang, S. H.; Ondrechen, M. J.; Pollastri, M. P. & Jones, G. B. “Fluorinated adenosine A2A receptor antagonists inspired by Preladenant as potential cancer immunotherapeutics” International Journal of Medicinal Chemistry, 2017, article ID 4852537. [link]
65. Krishnan, H.; Ma, L.; Vasdev, N. & Liang S. H. “18F-Labeling of Sensitive Biomolecules for Positron Emission Tomography” Chemistry – A European Journal, 2017, 23, 15553 – 15577. [link] [full-text]
64. Yang, J.; Yang, J.; Wang, L.; Moore, A.; Liang, S. H. & Ran, C. “Synthesis-Free PET Imaging of Brown Adipose Tissue and TSPO via Combination of Disulfiram and 64CuCl2” Scientific Reports, 2017, 7, 8298. [link]
63. Dahl, K.; Collier, T. L.; Cheng, R.; Zhang, X.; Sadovski, O.; Liang, S. H. and Vasdev, N. ““In-Loop” [11C]CO2-Fixation: Prototype and Proof-of-Concept” Journal of Labelled Compounds and Radiopharmaceuticals, 2017, 60, accepted. [link]
62. Collier, T. L.; Normandin, M. D.; Stephenson, N. A.; Livni, E.; Liang, S. H.; Wooten, D. W.; Esfahani, S. A.; Stabin, M. G.; Mahmood, U.; Chen, J.; Wang, W.; Maresca, K.; Waterhouse, R. N.; El Fakhri, G.; Richardson, P. & Vasdev, N. “Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib” Nature Communications, 2017, 8, 15761. DOI: 10.1038/ncomms15761 [link]
61. Ma, L.; Placzek, M. S.; Hooker, J. M.; Vasdev, N. & Liang, S. H. “[11C]Cyanation of arylboronic acids in aqueous solutions” Chemical Communications, 2017, 53, 6597-6600. [link] [full-text]
60. Wang, L.； Cheng, R.; Fujinaga, M.; Yang, J.; Zhang, Y.; Hatori, A.; Kumata, K.; Yang, J.; Vasdev, N.; Du, Y.; Ran, C.; Zhang, M-R. & Liang, S. H. “A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation” Journal of Medicinal Chemistry, 2017, 60, 5222-5227. [link] [full-text]
59. Zheng, J.; Cheng, R.; Lin, J-H.; Yu, D-H.; Ma, L.; Jia, L.; Zhang, L.; Wang, L.; Xiao, J-C. & Liang, S. H. “An unconventional mechanistic insight on SCF3 formation from difluorocarbene: Preparation of 18F-labeled α-SCF3 carbonyl compounds” Angewandte Chemie International Edition, 2017, in press. [link] [full-text]
58. Hu, K.; Patnaik, D.; Collier, T. L.; Lee, K. N.; Gao, H.; Swoyer, M. R.; Rotstein, B. H.; Krishnan, H. S.; Liang, S. H.; Wang, J.; Yan, Z.; Hooker, J. M.; Vasdev, N.; Haggarty, S. J. & Ngai, M-Y. “Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3b Ligands for Positron Emission Tomography Imaging”ACS Medicinal Chemistry Letters, 2017, in press. [link]
57. Yuan, G.; Wang, F.; Stephenson, N. A.; Wang, L.; Rotstein, B. H.; Vasdev, N.; Tang, P. & Liang, S. H. “Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation” Chemical Communications, 2017, 53, 126-129. [link]
56. Yang, J.; Yang, J.; Liang, S. H.; Xu, Y.; Moore, A. & Ran. C. “Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification” Scientific Reports, 2016, 6, 35613. [link]
55. Yuan, Z.; Cheng, R.; Chen, P.; Liu, G. & Liang, S. H. “Efficient Pathway for the Preparation of Aryl(isoquinoline)iodonium(III) Salts and Synthesis of Radiofluorinated Isoquinolines” Angewandte Chemie International Edition, 2016, 55, 11882-11886. [link]
54. Rotstein, B. H.; Placzek, M. S.; Krishnan, H. S.; Pekosak, A.; Collier, T. L.; Wang, C.; Liang, S. H.; Burstein, E. S.; Hooker, J. M. & Vasdev, N. “Preclinical PET neuroimaging of Preclinical PET neuroimaging of [11C]bexarotene” Molecular Imaging, 2016, 15, 1-5. [open access] [full-text]
53. Yuan, G.; Jones, G. B.; Vasdev, N. & Liang, S. H. “Radiosynthesis and preliminary PET evaluation of 18F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1, 2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors” Bioorganic & Medicinal Chemistry Letters, 2016, 26, 4857-4860. [link]
52. Shi, H.; Braun, A.; Wang, L.; Liang, S. H.*; Vasdev, N* & Ritter, T.* “Practical Synthesis of 18F-Difluoromethylarenes from Aryl (Pseudo) Halides” Angewandte Chemie International Edition, 2016, 55, 10786-90. [link]
51. Liang, S. H.; Chen, M. J.; Normandin, M. D.; Chang, J. S.; Chang, G. C.; Taylor, C. K.; Trapa, P.; Plummer, M. S.; Para, K. S.; Conn, E. L.; Lopresti-Morrow, L.; Lanyon, L. F.; Cook, J. M.; Richter, K. E. G.; Nolan, C. E.; Schachter, J. B.; Janat, F.; Che, Y.; Shanmugasundaram, V.; Lefker, B. A.; Enerson, B. E.; Livni, E.; Wang, L.; Guehl, N.; Patnaik, D.; Wagner, F. F.; Perlis, R.; Holson, E. B.; Haggarty, S. J.; El Fakhri, G.; Kurumbail, R. G. & Vasdev, N. “Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) that Modulates Tau Phosphorylation in Brain: Translation for PET Neuroimaging” Angewandte Chemie International Edition, 2016, 55, 9601-5. [link]
50. Rotstein, B. H.; Liang, S. H.; Placzek, M. S.; Hooker, J. M.; Gee, A. D.; Dollé, F.; Wilson, A. A. & Vasdev, N. “11C=O Bonds Made Easily for Positron Emission Tomography Radiopharmaceuticals” Chemical Society Reviews, 2016, 45, 4708-26. [link]
49. Rotstein, B. H.; Wang, L.; Liu, R. Y.; Patteson, J.; Kwan, E. E.; Vasdev, N. & Liang, S. H. “Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides” Chemical Science, 2016, 7, 4407 – 4417. [full-text]
48. Wang, L.; Mori, W.; Cheng, R.; Yui, J.; Hatori, A.; Ma, L.; Zhang, Y.; Rotstein, B. H.; Fujinaga, M.; Shimoda, Y.; Yamasaki, T.; Xie, L.; Nagai, Y.; Minamimoto, T.; Higuchu, M.; Vasdev, N.; Zhang, M.-R. & Liang, S. H. “Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase” Theranostics, 2016, 6, 1145-1159. [full-text]
47. Rashidian, M.; Wang, L.; Eden, J. G.; Jacobsen, J.; Hossain, I.; Wang, Q.; Victoria, G. D.; Vasdev, N.; Ploegh, H. & Liang, S. H. “Enzyme-Mediated Modification of Single Domain Antibodies for Imaging Modalities with different Characteristics” Angewandte Chemie International Edition, 2016, 55, 528-533. [full-text]
46. Wang, L.; Yui, J.; Wang, Q.; Zhang, Y.; Mori, W.; Shimoda, Y.; Fujinaga, M.; Kumata, K.; Yamasaki, T.; Hatori, A.; Rotstein, B. H.; Collier, T. L.; Ran, C.; Vasdev, N.; Zhang, M. -R. & Liang, S. H. “Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([11C]MPPO) Based on alpha-Ketoheterocyclic Scaffold” ACS Chemical Neuroscience, 2016, 7, 109-18. [full-text]
45. Kassenbrock, A.; Vasdev, N. & Liang, S. H. “Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors” Current Topics in Medicinal Chemistry, 2016, 16, 1830-42. [full-text]
44. Wang, L.; Jacobsen, O.; Avdic, D.; Rotstein, B. H.; Weiss, I. D.; Collier, L.; Chen, X.; Vasdev, N. & Liang, S. H. “Ortho-stabilized 18F-azido click agents and application in PET imaging of single-stranded DNA aptamer” Angewandte Chemie International Edition, 2015, 54, 12777-81. [full-text]
43. Zheng, J.; Wang, L.; Lin, J.-H.; Xiao, J.-C. & Liang, S. H. “Difluorocarbene-derived Trifluoromethylthiolation and [18F]Trifluoromethylthiolation of Aliphatic Electrophiles” Angewandte Chemie International Edition, 2015, 54, 13236-40. [full-text]
42. Jacobson, O.; Weiss, I.; Wang, L.; Wang, Z.; Yang, X.; Dewhurst, A.; Ma, Y.; Zhu, G.; Niu, G.; Kiesewetter, D. O.; Vasdev, N.; Liang, S. H.* & Chen, X.* “18F-labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression” Journal of Nuclear Medicine, 2015, 56, 1780-5; [full-text]
41. Stephenson, N. A.; Holland, J. P.; Kassenbrock, A.; Yokell, D. L.; Livni, E.; Liang, S. H. & Vasdev, N. “Iodonium Ylide–Mediated Radiofluorination of 18F-FPEB and Validation for Human Use” Journal of Nuclear Medicine, 2015, 56, 489-92. [full-text]
40. Calderwood, S.; Collier, T. L.; Gouverneur, V.; Liang, S. H.* & Vasdev, N.* “Synthesis of 18F-arenes from spirocyclic iodonium(III) ylides via continuous-flow microfluidics” Journal of Fluorine Chemistry, 2015, 178, 249-253. [full-text]
39. Liang, S. H. & Vasdev, N. “Total Radiosynthesis: Thinking Outside ‘the Box'” Australian Journal of Chemistry, 2015, 68, 1319-28. [full-text]
38. Liang, S. H.; Southon, A. G.; Fraser, B. H.; Krause-Heuer, A. M.; Zhang, B.; Shoup, T. M.; Lewis, R.; Volitakis, I.; Han, Y.; Greguric, I.; Bush, A. I. & Vasdev, N. “Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer’s Disease” ACS Medicinal Chemistry Letters, 2015, 6, 1025-9. [full-text]
37. Feng, M.; Tang, B.; Liang, S. H.* & Jiang, X.* “Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry” Current Topics in Medicinal Chemistry, 2015, 15, 15. [full-text]
36. Ren, W.; Xu, M.; Liang, S. H.; Xiang, H.; Tang, L.; Zhang, M.; Ding, D.; Li, X.; Zhang, H. & Hu, Y. “Discovery of a novel fluorescent probe for the sensitive detection of β-amyloid Deposits” Biosensors and Bioelectronics, 2015, 75, 136-141. [full-text]
35. Liang, S. H.; Holland, J. P.; Stephenson, N. A.; Kassenbrock, A.; Rotstein, B. H.; Daignault, C. P.; Lewis, R.; Collier, L.; Hooker, J. M. & Vasdev, N. “PET Neuroimaging Studies of [18F]CABS13 in a Double Transgenic Mouse Model of Alzheimer’s Disease and Nonhuman Primates” ACS Chemical Neuroscience, 2015, 6, 535-41. [full-text]
34. Liang, S. H.; Yokell, D. L.; Jackson, R. N.; Rice, P. A.; Livni, E.; Alagille, D.; Tamagnan, G.; Collier, T. L. & Vasdev, N., Synthesis of 3-[18F]fluoro-5-(2-pyridinylethynyl)benzonitrile ([18F]FPEB). In Radiochemical Syntheses, Vol 2:Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production, Scott, P. J. H., Ed. John Wiley & Sons, Inc.: Hoboken, New Jersey, 2015; Vol. 2, pp 41-51.
33. Rotstein, B. H.; Liang, S. H.; Belov, V. V.; Livni, E.; Levine, D. B.; Bonab, A. A.; Papisov, M. I.; Perlis, R. H. & Vasdev, N. “Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist” Molecules, 2015, 20, 9550-9. [full-text]
32. Rotstein, B. H.; Stephenson, N. A.; Vasdev, N. & Liang, S. H. “Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics” Nature Communications, 2014, 5, 4365. [Open Access]
31. Liang, S. H.* & Vasdev, N.* “C(sp3)-18F Bond Formation by Transition-Metal-Based [18F]Fluorination” Angewandte Chemie International Edition, 2014, 53, 11416-8. [full-text]
30. Kasahara, T.; Jang, Y. J.; Racicot, L.; Panagopoulos, D.; Liang, S. H. & Ciufolini, M. A. “Iodonium metathesis reactions” Angewandte Chemie International Edition, 2014, 53, 9637-9. [link] [full text]
29. Liang, S. H.; Yokell, D. L.; Jackson, R. N.; Rice, P. A.; Callahan, R.; Johnson, K. A.; Alagille, D.; Tamagnan, G.; Collier, T. L. & Vasdev, N. “Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging” RSC Medicinal Chemistry, 2014, 5, 432-5. [full-text]
28. Liang, S. H.; Yokell, D. L.; Normandin, M. D.; Rice, P. A.; Jackson, R. N.; Shoup, T. M.; Brady, T. J.; El Fakhri, G.; Collier, T. L. & Vasdev, N. “First Human Use of a Radiopharmaceutical Prepared by Continuous-Flow Microfluidic Radiofluorination: Proof of Concept with the Tau Imaging Agent [18F]T807″ Molecular Imaging, 2014, 13, 1-5. [link]
27. Li, X.; Yang, C.; Wu, K.; Hu, Y.; Han, Y. & Liang, S. H. “A highly specific probe for sensing hydrogen sulfide in live cells based on copper-initiated fluorogen with aggregation-induced emission characteristics” Theranostics, 2014, 4, 1233-8. [full-text]
26. Holland, J. P.; Liang, S. H.; Rotstein, B. H.; Collier, T. L.; Stephenson, N. A.; Greguric, I. & Vasdev, N. “Alternative approaches for PET radiotracer development in Alzheimer’s disease: imaging beyond plaque” Journal of Labelled Compounds and Radiopharmaceuticals, 2014, 57, 323-31. [link]
25. Li, X.; Gong, Y.; Wu, K.; Liang, S. H.; Cao, J.; Yang, B.; Y., H. & Han, Y. “A highly sensitive and water soluble fluorescent probe for rapid detection of hydrogen sulfide in living cells” RSC Advances, 2014, 4, 36106-9. [link]
24. Rotstein, B.; Liang, S. H. & Vasdev, N. “Clinical PET Research Realized by [11C]CO2-Fixation” Molecular Imaging Gateway 2014, 8. [link]
23. Rotstein, B. H.; Hooker, J. M.; Woo, J.; Collier, T. L.; Brady, T. J.; Liang, S. H.* & Vasdev, N.* “Synthesis of [11C]Bexarotene by Cu-Mediated [11C]Carbon Dioxide Fixation and Preliminary PET Imaging” ACS Medicinal Chemistry Letters, 2014, 5, 668-72. [full-text]
22. Rotstein, B. H.; Wey, H. Y.; Shoup, T. M.; Wilson, A. A.; Liang, S. H.; Hooker, J. M. & Vasdev, N. “PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Nonhuman Primates” Molecular Pharmaceutics, 2014, 11, 3832-8. [full-text]
21. Liang, S. H.; Collier, T. L.; Rotstein, B. H.; Lewis, R.; Steck, M. & Vasdev, N. “Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds” Chemical Communications, 2013, 49, 8755-7. [link]
20. Rotstein, B. H.; Liang, S. H.; Holland, J. P.; Collier, T. L.; Hooker, J. M.; Wilson, A. A. & Vasdev, N. “11CO2 fixation: a renaissance in PET radiochemistry” Chemical Communications, 2013, 49, 5621-9. [link] [full-text]
Selected publications (total 19 papers) from doctoral and postdoctoral work
Liang, H.; Hu, L.; Corey, E. J. “Di-tert-butylisobutylsilyl, another useful protecting group” Organic Letters, 2011, 13, 4120-3.
Liang, H.; Ciufolini, M. A. “Chiral hypervalent iodine reagents in asymmetric reactions” Angewandte Chemie International Edition, 2011, 50, 11849-51.
Liang, H.; Ciufolini, M. A. “Oxidative Spirocyclization of Phenolic Sulfonamides: Scope and Applications” Chemistry – A European Journal, 2010, 16, 13262-70.
Liang, H.; Ciufolini, M. A. “Tandem Phenolic Oxidative Amidation−Intramolecular Diels−Alder Reaction: An Approach to the Himandrine Core” Organic Letters, 2010, 12, 1760-3.
Liang, H.; Ciufolini, M. A. “Improved Procedure for the Bimolecular Oxidative Amidation of Phenols” Journal of Organic Chemistry, 2008, 73, 4299-301.
Liang, H.; Schulé, A.; Vors, J.-P.; Ciufolini, M. A. “An Avenue to the Sordarin Core Adaptable to Analog Synthesis” Organic Letters, 2007, 9, 411922.