A list of radioactive drugs & PET ligands developed/characterized by our group (drug targets in alphabetical order)
D-Amino acid oxidase (DAAO)
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor with or without focusing GluA2 subunit (GluA2)
Anaplastic lymphoma kinase – [11C/18F]lorlatinib drug labeling
Autotaxin (ATX)
Cholesterol 24S-hydroxylase (CYP46A1)
Fatty acid amide hydrolase (FAAH)
Glycogen synthase kinase 3 (GSK3)
Histamine H3 receptor (H3)
L-Type Amino Acid Transporter (LAT1)
under review
L-Type calcium channel
Leucine-rich repeat kinase 2 (LRRK2)
Metabotropic glutamate receptor 2 (mGluR2)
Metabotropic glutamate receptor 7 (mGluR7)
Metal binder in the brain – copper (Cu) and Zinc (Zn) binder
N-Methyl D-aspartate (NMDA) receptor subtype 2B (NR2B or GluN2B)
Monoacylglycerol lipase (MAGL)
Muscarinic acetylcholine receptor subtype 4 (M4)
Orexin receptor 2 (OX2)
Phosphodiesterase 1 (PDE1)
Phosphodiesterase 4B (PDE4B)
In progress
Phosphodiesterase 7 (PDE7)
Phosphodiesterase 10A (PDE10A)
Poly [ADP-ribose] polymerase 1 (PARP1)
Protein tyrosine kinase 7 (PTK-7) – single-stranded DNA aptamer targeted PET ligand (18F-sgc8)
Retinoid X receptors (RXRs) – repurposing Bexarotene for Alzheimer’s treatment
RNA-dependent RNA polymerase (RdRp) – pharmacokinetics study of [18F]Favipiravir in the brain
Single domain antibody fragments (VHHs) – click chemistry applications of anti class II MHC and anti CD11b targeted PET imaging
Trace amine-associated receptor subtype 1 (TAAR1)
Translocator protein (TSPO)
Transmembrane AMPAR regulatory protein (TARP) – gamma 8 subtype (TARP γ8)
Vasopressin receptor 1A (V1A)
