Anaphylaxis: 5 Clinically Relevant Questions: 1) Whats the difference between anaphylaxis and anaphylactoid? Anaphylaxis: IgE mediated Anaphylactoid: Direct degranulation of mast cells 2) What are the main causes? Main classes: Food, insects, medications. –PCN Cross Reactivity with Cephalosporin? True incidence <0.1% true anaphylactic cross reactivity –Radiocontrast material(RCM): Shellfish and iodine allergies are not relevant! That being …