EH 720: Introduction to Physiologically-Based Toxicokinetic/Pharmacokinetic Modeling

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EH 720: Introduction to Physiologically-Based Toxicokinetic/Pharmacokinetic Modeling

Category : Academic Student Opportunities

Description 

There is still space available to register in EHS 720: Introduction to Physiologically-Based Toxicokinetic (PBTK)/Pharmacokinetic (PBPK) Modeling with Dr. Qiang Zhang!

The health effects of environmental or pharmaceutical chemicals depend on the concentrations of the xenobiotics and their metabolites in the target tissues. Understanding and predicting chemical internal concentrations (tissue dosimetry) requires a physiologically-based toxicokinetic (PBTK) or pharmacokinetic (PBPK) modeling approach. Based on human physiology and anatomy, PBTK/PBPK models mechanistically simulate the absorption, distribution, metabolism, and elimination (ADME) processes that affect the fates of exogenous chemicals in the human body, producing, as model output, changes in chemical tissue concentrations over time. PBTK/PBPK modeling has be increasingly applied in chemical health risk assessment and drug development. Students will learn numerical simulation tools to model what the body does to the chemicals in this course. It targets:

  • Environmental health science students interested in chemical tissue dosimetry, internal exposure, interpretation of biomarkers of exposures, in vitro to in vivo extrapolation (IVIVE) of chemical dosimetry
  • Pharmacology/toxicology students interested in quantitative simulation of tissue- specific drug dosimetry beyond classical, compartmental PK.
  • Students and researchers in biosciences, nutritional science, anesthesiology, biomedical engineering, and chemical engineering interested in computational approaches to predicting tissue concentrations of environmental, industrial, dietary, and pharmaceutical chemicals.

 

See the flyer below for more information about this spring course!

 

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  • The Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID) July 15, 2024 – July 31, 2024 Conference / Symposium Event Type: Conference / SymposiumSeries: The Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID)Speaker: Leaders in the FieldContact Name: Pia ValerianoContact Email: pvaleri@emory.eduLink: https://sph.emory.edu/SISMID/index.htmlThe Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID) is designed to introduce infectious disease researchers to modern methods of statistical analysis and mathematical modeling.
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Upcoming Events
  • The Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID) July 15, 2024 – July 31, 2024 Conference / Symposium Event Type: Conference / SymposiumSeries: The Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID)Speaker: Leaders in the FieldContact Name: Pia ValerianoContact Email: pvaleri@emory.eduLink: https://sph.emory.edu/SISMID/index.htmlThe Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID) is designed to introduce infectious disease researchers to modern methods of statistical analysis and mathematical modeling.
  • Functional Biomarkers for Early Detection and Treatment of Diabetic Retinopathy August 5, 2024 at 12:00 pm – 1:00 pm Zoom Online Location: ZoomSeries: EGDRC Seminar SeriesSpeaker: Dr. Machelle PardueContact Name: Wendy GillContact Email: wggill@emory.eduLink: https://tinyurl.com/Machelle-PardueDr. Pardue’s lab is focused on clinically relevant treatments for retinal disease that can make a difference in the quality of life of patients. She is developing novel screening and treatment strategies for early-stage diabetic retinopathy and elucidating the retinoscleral mechanisms…
  • The Second Annual RSPH Staff and Post-Doctoral Ice Cream Social August 14, 2024 at 1:00 pm – 2:00 pm Networking and Special Event Event Type: Networking,Special EventContact Name: Staff CouncilContact Email: rsphstaffcouncil@emory.eduRoom Location: RRR_Terrace 2nd FloorRSPH staff and post-docs are invited to join us for ice cream and delightful conversation. This event is hosted by the RSPH Staff Council.
  • Tricks and Treats with the Council, hosted by the RSPH Staff Council October 31, 2024 at 10:00 am – 11:30 am Networking and Special Event Event Type: Networking,Special EventContact Name: Staff CouncilContact Email: rsphstaffcouncil@emory.eduRoom Location: CNR_8030 Lawrence P. &Ann Estes Klamon roomRSPH staff and post-docs are invited to join the RSPH Staff Council for a festive gathering featuring sweet treats and refreshments. Costumes are encouraged but not required.
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