Phenotypic and genetic data from NIAAA’s Collaborative Study on the Genetics of Alcoholism will be used to examine endophenotypes that capture the biological mechanisms related to alcohol withdrawal. The endophenotypes will be used to assess the joint distribution of genetic effects that comprise specific neural and molecular pathways that underlie alcohol withdrawal and derive more accurate representations of individual differences in alcohol withdrawal. This will be achieved using a systems biology framework as previously described in Palmer et al., 2012, Drug and Alcohol Dependence, 125(3).
Collaborators: Drs. Kathleeen Bucholz and Andrew Heath, Collaborative Study on the Genetics of Alcoholism (COGA) Project
Student Poster: An Examination of the Genetic Architecture of Alcohol Withdrawal